Search Results - "Labruyere, Joann"

Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain by Young, Chainllie, Jevtovic‐Todorovic, Vesna, Qin, Yue‐Qin, Tenkova, Tatyana, Wang, Haihui, Labruyere, Joann, Olney, John W

“…Recently, it was reported that anesthetizing infant rats for 6 h with a combination of anesthetic drugs (midazolam, nitrous oxide, isoflurane) caused…”
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Role of caspase-3 in ethanol-induced developmental neurodegeneration by Young, Chainllie, Roth, Kevin A., Klocke, Barbara J., West, Tim, Holtzman, David M., Labruyere, Joann, Qin, Yue-Qin, Dikranian, Krikor, Olney, John W.

“…Acute, transient exposure to ethanol causes a widespread pattern of caspase-3 activation and neuroapoptosis in the developing rodent brain. To determine…”
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Apoptosis in the in Vivo Mammalian Forebrain by Dikranian, Krikor, Ishimaru, Masahiko J., Tenkova, Tatyana, Labruyere, Joann, Qin, Y.Q., Ikonomidou, Chrysanthy, Olney, John W.

“…Apoptosis is a word originally introduced by Kerr, Wyllie, and colleagues for a cell death process they defined in terms of its ultrastructural appearance in…”
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Ethanol-induced neuroapoptosis in the developing rodent cerebellum and related brain stem structures by Dikranian, Krikor, Qin, Yue-Qin, Labruyere, Joann, Nemmers, Brian, Olney, John W.

“…For three decades since the fetal alcohol syndrome (FAS) was first described, researchers have been keenly interested in understanding the mechanism(s) by…”
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Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain by Olney, John W, Tenkova, Tatyana, Dikranian, Krikor, Qin, Yue-Qin, Labruyere, Joann, Ikonomidou, Chrysanthy

“…Recent studies have shown that administration of ethanol to infant rats during the synaptogenesis period (first 2 weeks after birth), triggers extensive…”
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Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs by Olney, John W., Labruyere, Joann, Price, Madelon T.

“…Phencyclidine (PCP), a dissociative anesthetic and widely abused psychotomimetic drug, and MK-801, a potent PCP receptor ligand, have neuroprotective…”
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l-Cysteine, a Bicarbonate-Sensitive Endogenous Excitotoxin by Olney, John W., Zorumski, Charles, Price, Madelon T., Labruyere, Joann

“…After systemic administration to immature rodents, l-cysteine destroys neurons in the cerebral cortex, hippocampus, thalamus, and striatum, but the underlying…”
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The role of specific ions in glutamate neurotoxicity by Olney, J W, Price, M T, Samson, L, Labruyere, J

“…When the chick embryo retina is incubated in balanced salt solution containing glutamate (Glu) in 1 mM concentration, a neurodegenerative reaction occurs…”
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Comparison of Rat Retinal Fixation Techniques: Chemical Fixation and Microwave Irradiation by IZUMI, YUKITOSHI, HAMMERMAN, SETH B, BENZ, ANN M, LABRUYERE, JOANN, ZORUMSKI, CHARLES F, OLNEY, JOHN W

“…In histological studies using retinas, eyes are commonly fixed with aldehyde derivatives administered by immersion or perfusion. However, the histology of rat…”
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An ex vivo rat retinal preparation for excitotoxicity studies by Izumi, Yukitoshi, Benz, Ann M., Kirby, Charity O., Labruyere, Joann, Zorumski, Charles F., Price, Madelon T., Olney, John W.

“…Although the isolated chicken embryo retina has been a very useful in vitro preparation for studying mechanisms of excitotoxicity, it is an avian rather than…”
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Ethanol-Induced Apoptosis in the Developing Visual System during Synaptogenesis by Tenkova, Tatyana, Young, Chainllie, Dikranian, Krikor, Labruyere, Joann, Olney, John W

“…Ethanol is known to have deleterious effects on the human fetal nervous system (fetal alcohol syndrome), including components of the visual system, but only…”
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Age dependent sensitivity of the rat retina to the excitotoxic action ofN-methyl-D-aspartate by Izumi, Yukitoshi, Kirby-Sharkey, Charity O., Benz, Ann M., Labruyere, Joann, Price, Madelon T., Wozniak, David F., Zorumski, Charles F., Olney, John W.

“…We have found that the rat retina can be isolated atraumatically and incubatedex vivofor up to 24 h without showing signs of histological deterioration, and…”
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Spatiotemporal evolution of apoptotic neurodegeneration following traumatic injury to the developing rat brain by Bayly, Philip V., Dikranian, Krikor T., Black, Erin E., Young, Chainllie, Qin, Yue-Qin, Labruyere, Joann, Olney, John W.

“…Closed head injury to the developing rat brain causes an acute excitotoxic lesion and axonal disruption at the impact site followed by a delayed pattern of…”
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Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: Potential relevance to schizophrenia? by Farber, Nuri B., Wozniak, David F., Price, Madelon T., Labruyere, Joann, Huss, Janice, St. Peter, Heidi, Olney, John W.

“…Agents that block the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor induce a schizophrenialike psychosis in adult humans and injure or kill neurons…”
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Motor Neuron Degeneration Induced by Excitotoxin Agonists Has Features in Common with those Seen in the SOD-1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis by Ikonomidou, Chrysanthy, Qin, Yue Qin, Labruyere, Joann, Olney, John W

“…A superoxide dismutase 1 (SOD-1) genetic defect has been identified in familial amyotrophic lateral sclerosis (ALS) and motor neuron degeneration has been…”
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Prevention of trauma-induced neurodegeneration in infant rat brain by IKONOMIDOU, C, QIN, Y, LABRUYERE, J, KIRBY, C, OLNEY, J. W

“…Recent evidence implicates the endogenous excitatory neurotransmitters, glutamate (Glu) and aspartate, in the pathophysiology of traumatic injury in the adult…”
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Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity by Farber, N B, Price, M T, Labruyere, J, Nemnich, J, St Peter, H, Wozniak, D F, Olney, J W

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Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases by Olney, J W, Zorumski, C F, Stewart, G R, Price, M T, Wang, G J, Labruyere, J

“…Despite several decades of research aimed at elucidating the mechanisms underlying neuronal degeneration in Parkinson's and Huntington's diseases, these…”
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MK-801 powerfully protects against N-methyl aspartate neurotoxicity by Olney, J, Price, M, Salles, K S, Labruyere, J, Frierdich, G

“…Using the ex vivo chick embryo retina to study the efficacy of antagonists in blocking the excitotoxic effects of excitatory amino acid agonists, we previously…”
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Seizure-related brain damage induced by cholinergic agents by Olney, John W, de Gubareff, Taisija, Labruyere, Joann

“…Distinctive acute brain damage involving limbic and related brain regions develops in adult rats following sustained limbic seizures induced by systemic…”
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