Search Results - "Labrie, Claude"

Gonadotropin-Releasing Hormone Agonists in the Treatment of Prostate Cancer by Labrie, Fernand, Bélanger, Alain, Luu-The, Van, Labrie, Claude, Simard, Jacques, Cusan, Leonello, Gomez, José, Candas, Bernard

“…In 1979, the first prostate cancer patient was treated with a GnRH agonist at the Laval University Medical Center in Québec City, Canada, thus rapidly leading…”
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The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology by Labrie, Fernand, Luu-The, Van, Lin, Sheng-Xiang, Claude, Labrie, Simard, Jacques, Breton, Roch, Bélanger, Alain

“…17β-Hydroxysteroid dehydrogenase (17β-HSD) controls the last step in the formation of all androgens and all estrogens. This crucial role of 17β-HSD is…”
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Regulation of the Human Cyclin-dependent Kinase Inhibitor p18 by the Transcription Factors E2F1 and Sp1 by Blais, Alexandre, Monté, Didier, Pouliot, Frédéric, Labrie, Claude

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DHEA and the Intracrine Formation of Androgens and Estrogens in Peripheral Target Tissues: Its Role during Aging by Labrie, Fernand, Bélanger, Alain, Luu-The, Van, Labrie, Claude, Simard, Jacques, Cusan, Leonello, Gomez, Jose-Luis, Candas, Bernard

“…Human and some other primates are unique since their adrenals secrete large amounts of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S), which are…”
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Evaluation of AIbZIP and Cdc47 as Markers for Human Prostatic Diseases by Levesque, Marie-Hélène, El-Alfy, Mohamed, Berger, Louise, Labrie, Fernand, Labrie, Claude

“…Objectives Benign prostatic hyperplasia and prostate cancer are important public health issues. However, histologic markers for these diseases are limited…”
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Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid by Labrie, Fernand, Luu-The, Van, Calvo, Ezequiel, Martel, Céline, Cloutier, Julie, Gauthier, Sylvain, Belleau, Pascal, Morissette, Jean, Lévesque, Marie-Hélène, Labrie, Claude

“…Tetrahydrogestrinone (THG) is a recently identified compound having the greatest impact in the world of sports. In order to obtain a highly accurate and…”
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Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells by Qi, Heng, Grenier, Josée, Fournier, Andréa, Labrie, Claude

“…The NEDD4L gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation. A search for transcripts whose levels increase following…”
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Intracrinology and the skin by Labrie, F, Luu-The, V, Labrie, C, Pelletier, G, El-Alfy, M

“…The skin, the largest organ in the human body, is composed of a series of androgen-sensitive components that all express the steroidogenic enzymes required to…”
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Expression profile of agonistic Smads in human breast cancer cells: Absence of regulation by estrogens by Pouliot, Frederic, Labrie, Claude

“…Transforming growth factor‐β1 (TGF‐β1) is a cytokine expressed by mammary cells. While TGF‐β1 can inhibit the proliferation of human breast cancer cells, many…”
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Activity and Safety of the Antiestrogen EM-800, the Orally Active Precursor of Acolbifene, in Tamoxifen-Resistant Breast Cancer by LABRIE, Fernand, CHAMPAGNE, Pierre, L'ESPERANCE, Bernard, DUFRESNE, Jean, LATREILLE, Jean, ROBERT, Jean, SAMSON, Benoit, JOLIVET, Jacques, YELLE, Louise, CUSAN, Lionel, DIAMOND, Pierre, CANDAS, Bernard, LABRIE, Claude, ROY, Jean, LAVERDIERE, Jacques, PROVENCHER, Louise, POTVIN, Martin, DROLET, Yvan, POLLAK, Michael, PANASCI, Lawrence

“…To determine the efficacy and safety of EM-800 (SCH-57050), the precursor of acolbifene, a new, highly potent, orally active, pure antiestrogen in the mammary…”
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Bioavailability and Pharmacokinetics of Dehydroepiandrosterone in the Cynomolgus Monkey by Leblanc, Mathias, Labrie, Claude, Bélanger, Alain, Candas, Bernard, Labrie, Fernand

“…We have studied the pharmacokinetics of dehydroepiandrosterone (DHEA) administered orally (PO), iv, and during a continuous iv infusion in ovariectomized…”
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Almost Exclusive Androgenic Action of Dehydroepiandrosterone in the Rat Mammary Gland by Sourla, Antigone, Martel, Céline, Labrie, Claude, Labrie, Fernand

“…To determine the relative role of the androgenic and/or estrogenic components of the action of dehydroepiandrosterone (DHEA) on the histomorphology and…”
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Isolation of the Novel Human Guanine Nucleotide Exchange Factor Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor (SGEF) and of C-Terminal SGEF, an N-Terminally Truncated Form of SGEF, the Expression of Which Is Regulated by Androgen in Prostate Cancer Cells by Qi, Heng, Fournier, Andréa, Grenier, Josée, Fillion, Catherine, Labrie, Yvan, Labrie, Claude

“…In searching for androgen-responsive genes in human prostate cancer cells, we have isolated two cDNAs that encode alternate forms of a novel Src homology 3…”
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Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey by Leblanc, Mathias, Labrie, Claude, Bélanger, Alain, Candas, Bernard, Labrie, Fernand

“…Humans and primates are unique in having adrenals that secrete large amounts of DHEA and DHEA-S in the circulation. These steroids act as precursors of active…”
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Treatment of pain at sexual activity (dyspareunia) with intravaginal dehydroepiandrosterone (prasterone) by Archer, David F, Labrie, Fernand, Bouchard, Céline, Portman, David J, Koltun, William, Cusan, Leonello, Labrie, Claude, Côté, Isabelle, Lavoie, Lyne, Martel, Céline, Balser, John

“…OBJECTIVE:This study aims to confirm the local effects of intravaginal prasterone on moderate to severe dyspareunia, a symptom of vulvovaginal atrophy (VVA)…”
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(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800):  A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen by Gauthier, Sylvain, Caron, Brigitte, Cloutier, Julie, Dory, Yves L, Favre, Alexandre, Larouche, Denis, Mailhot, Josée, Ouellet, Carl, Schwerdtfeger, Annette, Leblanc, Gilles, Martel, Céline, Simard, Jacques, Mérand, Yves, Bélanger, Alain, Labrie, Claude, Labrie, Fernand

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The co-chaperone DNAJC12 binds to Hsc70 and is upregulated by endoplasmic reticulum stress by Choi, Jin, Djebbar, Sonia, Fournier, Andréa, Labrie, Claude

“…Human DNAJC12 is a J domain-containing protein whose regulation, subcellular localization, and function are currently unknown. We show here that the abundance…”
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Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by rasV12 mutated protein and the E1A oncogene by Vasseur, Sophie, Malicet, Cédric, Calvo, Ezequiel L, Labrie, Claude, Berthezene, Patrice, Dagorn, Jean Charles, Iovanna, Juan Lucio

“…Ras is an area of intensive biochemical and genetic studies and characterizing downstream components that relay ras-induced signals is clearly important. We…”
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Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes by Barbier, O, Albert, C, Martineau, I, Vallée, M, High, K, Labrie, F, Hum, D W, Labrie, C, Bélanger, A

“…EM-652 (SCH 57068) is a new orally active antiestrogen that demonstrates pure antagonistic effects in the mammary gland and endometrium. In vivo studies have…”
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Androgens Down-Regulate bcl-2 Protooncogene Expression in ZR-75-1 Human Breast Cancer CellsThis work was supported by a grant from the Canadian Breast Cancer Research Initiative (to C.L.), scholarships from the Fonds de la Recherche en Santé du Québec (to C.L. and J.L.). Additional financial support was provided by Endorecherche by Lapointe, Jacques, Fournier, Andréa, Richard, Virgile, Labrie, Claude

“…Although a large proportion of primary human breast cancers express the androgen receptor, and treatment with androgens exerts beneficial effects in women with…”
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