Search Results - "Labonte, Eric D"

Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans by Spencer, Andrew G, Labonte, Eric D, Rosenbaum, David P, Plato, Craig F, Carreras, Christopher W, Leadbetter, Michael R, Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Bell, Noah, Tabora, Jocelyn, Joly, Kristin M, Navre, Marc, Jacobs, Jeffrey W, Charmot, Dominique

“…The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an…”
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Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD by Labonté, Eric D, Carreras, Christopher W, Leadbetter, Michael R, Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Dy, Edward, Black, Deborah, Zhong, Ziyang, Langsetmo, Ingrid, Spencer, Andrew G, Bell, Noah, Deshpande, Desiree, Navre, Marc, Lewis, Jason G, Jacobs, Jeffrey W, Charmot, Dominique

“…In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism, metabolic bone disease,…”
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Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3 by Jacobs, Jeffrey W., Leadbetter, Michael R., Bell, Noah, Koo-McCoy, Samantha, Carreras, Christopher W., He, Limin, Kohler, Jill, Kozuka, Kenji, Labonté, Eric D., Navre, Marc, Spencer, Andrew G., Charmot, Dominique

“…We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na+/H+ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in…”
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Group 1B Phospholipase A2–Mediated Lysophospholipid Absorption Directly Contributes to Postprandial Hyperglycemia by LABONTE, Eric D, KIRBY, R. Jason, SCHILDMEYER, Nicholas M, CANNON, April M, HUGGINS, Kevin W, HUI, David Y

“…Group 1B Phospholipase A 2 –Mediated Lysophospholipid Absorption Directly Contributes to Postprandial Hyperglycemia Eric D. Labonté , R. Jason Kirby , Nicholas…”
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Preclinical and Healthy Volunteer Studies of Potential Drug–Drug Interactions Between Tenapanor and Phosphate Binders by Johansson, Susanne, Leonsson‐Zachrisson, Maria, Knutsson, Mikael, Spencer, Andrew G., Labonté, Eric D., Deshpande, Desiree, Kohler, Jill, Kozuka, Kenji, Charmot, Dominique, Rosenbaum, David P.

“…Tenapanor (RDX5791, AZD1722), a first‐in‐class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3…”
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Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice by Labonté, Eric D, Camarota, Lisa M, Rojas, Juan C, Jandacek, Ronald J, Gilham, Dean E, Davies, Joanna P, Ioannou, Yiannis A, Tso, Patrick, Hui, David Y, Howles, Philip N

“…The impact of NPC1L1 and ezetimibe on cholesterol absorption are well documented. However, their potential consequences relative to absorption and metabolism…”
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Development and physiological regulation of intestinal lipid absorption. III. Intestinal transporters and cholesterol absorption by Hui, David Y, Labonté, Eric D, Howles, Philip N

“…Intestinal cholesterol absorption is modulated by transport proteins in enterocytes. Cholesterol uptake from intestinal lumen requires several proteins on…”
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Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A₂ and diet-induced obesity by Labonté, Eric D, Pfluger, Paul T, Cash, James G, Kuhel, David G, Roja, Juan C, Magness, Daniel P, Jandacek, Ronald J, Tschöp, Matthias H, Hui, David Y

“…Decrease in fat catabolic rate on consuming a high-fat diet contributes to diet-induced obesity. This study used group 1B phospholipase A₂ (Pla2g1b)-deficient…”
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Carboxyl Ester Lipase Deficiency Exacerbates Dietary Lipid Absorption Abnormalities and Resistance to Diet-induced Obesity in Pancreatic Triglyceride Lipase Knockout Mice by Gilham, Dean, Labonté, Eric D., Rojas, Juan C., Jandacek, Ronald J., Howles, Philip N., Hui, David Y.

“…This study evaluated the contributions of carboxyl ester lipase (CEL) and pancreatic triglyceride lipase (PTL) in lipid nutrient absorption. Results showed PTL…”
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Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles by Labonté, Eric D., Howles, Philip N., Granholm, Norman A., Rojas, Juan C., Davies, Joanna P., Ioannou, Yiannis A., Hui, David Y.

“…Recent studies have documented the importance of Niemann–Pick C1-like 1 protein (NPC1L1), a putative physiological target of the drug ezetimibe, in mediating…”
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Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD by Labonté, Eric D., Carreras, Christopher W., Leadbetter, Michael R., Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Dy, Edward, Black, Deborah, Zhong, Ziyang, Langsetmo, Ingrid, Spencer, Andrew G., Bell, Noah, Deshpande, Desiree, Navre, Marc, Lewis, Jason G., Jacobs, Jeffrey W., Charmot, Dominique

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Group 1B phospholipase [A.sub.2]--mediated lysophospholipid absorption directly contributes to postprandial hyperglycemia by Labonte, Eric D, Kirby, R. Jason, Schildmeyer, Nicholas M, Cannon, April M, Huggins, Kevin W, Hui, David Y

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Separation and Quantitation of Bile Acids Using an Isocratic Solvent System for High Performance Liquid Chromatography Coupled to an Evaporative Light Scattering Detector by Torchia, Enrique C., Labonté, Eric D., Agellon, Luis B.

“…We developed a quantitative method for the analysis of bile acids using a high performance liquid chromatograph coupled to an evaporative light scattering…”
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The relative ligand binding preference of the murine ileal lipid binding protein by Labonté, Eric D, Li, Qianqian, Kay, Cyril M, Agellon, Luis B

“…The ileal lipid binding protein (ILBP), a member of the intracellular lipid binding protein family, is a 14-kDa protein that has bile and fatty acids as…”
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Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A 2 and diet‐induced obesity by Labonté, Eric D., Pfluger, Paul T., Cash, James G., Kuhel, David G., Roja, Juan C., Magness, Daniel P., Jandacek, Ronald J., Tschöp, Matthias H., Hui, David Y.

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Group 1B Phospholipase A^sub 2^-Mediated Lysophospholipid Absorption Directly Contributes to Postprandial Hyperglycemia by Labonté, Eric D, Kirby, R Jason, Schildmeyer, Nicholas M, Cannon, April M

“…Postprandial hyperglycemia is an early indicator of abnormality in glucose metabolism leading to type 2 diabetes. However, mechanisms that contribute to…”
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Expression of Cholesterol 7α-Hydroxylase Restores Bile Acid Synthesis in McArdle RH7777 Cells by Labonté, Eric D., Li, Qianqian, Agellon, Luis B.

“…Bile acid synthesis involves several enzymes and occurs only in liver cells. The first and rate-determining step is catalyzed by cholesterol 7α-hydroxylase…”
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