Search Results - "Labhardt, A M"

Direct NMR evidence for an intermediate preceding the rate-limiting step in the unfolding of ribonuclease A by Kiefhaber, Thomas, Labhardt, Alexander M, Baldwin, Robert L

“…It is commonly believed that there are no detectable intermediates in the kinetic unfolding reactions of small proteins. If such intermediates could be found,…”
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Selective interaction of Ni with an MHC‐bound peptide by Romagnoli, P., Labhardt, A.M., Sinigaglia, F.

“…T cells generally recognize foreign antigens as peptides associated with self‐molecules encoded by genes of the major histocompatibility complex (MHC)…”
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The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution by Klaus, W, Gsell, B, Labhardt, A M, Wipf, B, Senn, H

“…The solution structure of recombinant human interferon alpha-2a (Roferon-A) has been determined by multidimensional heteronuclear NMR spectroscopy. The…”
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Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments by Wyss, D F, Lahm, H W, Manneberg, M, Labhardt, A M

“…Anantin, a naturally occurring peptide from Streptomyces coerulescens, binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine…”
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Kinetic Circular Dichroism Shows That the S-peptide α -helix of Ribonuclease S Unfolds Fast and Refolds Slowly by Labhardt, A. M.

“…It is shown that circular dichroism (CD) can distinguish between the S-peptide and the S-protein fragments of RNase S at 225 nm and 235 nm. The conformational…”
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A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance by Dale, G E, Broger, C, D'Arcy, A, Hartman, P G, DeHoogt, R, Jolidon, S, Kompis, I, Labhardt, A M, Langen, H, Locher, H, Page, M G, Stüber, D, Then, R L, Wipf, B, Oefner, C

“…A single amino acid substitution, Phe98 to Tyr98, in dihydrofolate reductase (DHFR) is the molecular origin of trimethoprim (TMP) resistance in Staphylococcus…”
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Folding intermediates studied by circular dichroism by Labhardt, A M

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1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-γ by GRZESIEK, S, DÖBELI, H, GENTZ, R, GAROTTA, G, LABHARDT, A. M, BAX, A

“…1H, 13C, and 15N NMR assignments of the protein backbone of human interferon-gamma, a homodimer of 31.4 kDa, have been made using the recently introduced…”
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NMR studies of DNA duplexes singly cross-linked by different synthetic linkers by Altmann, Serge, Labhardt, Alexander M., Bur, Daniel, Lehmann, Christain, Bannwarth, Willi, Billeter, Martin, Wüthrich, Kurt, Leupin, Werner

“…Molecular modelling studies resulted in the design of a variety of non-nucleotidic covalent linkers to bridge the 3′-end of the (+)-strand and the 5′-end of…”
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Stopped-flow kinetics of the interaction of the fluorescent calcium indicator Quin 2 with calcium ions by Quast, U, Labhardt, A M, Doyle, V M

“…The kinetics of the Quin 2-Ca2+ interaction have been studied using stopped-flow fluorimetry. Mixing the Quin 2-Ca2+ complex with a large excess of EGTA, EDTA…”
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Secondary structure determination for α‐neurotoxin from Dendroaspis polylepis polylepis based on sequence‐specific 1H‐nuclear‐magnetic‐resonance assignments by LABHARDT, Alexander M., HUNZIKER‐KWIK, Eng‐Hiang, WÜTHRICH, Kurt

“…Sequence‐specific assignments are presented for the polypeptide backbone protons and a majority of the amino‐acid‐side‐chain protons of α‐neurotoxin from…”
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Nature of the fast and slow refolding reactions of iron(III) cytochrome c by Ridge, John A, Baldwin, Robert L, Labhardt, Alexander M

“…The fast and slow refolding reactions of iron(III) cytochrome c (Fe(III) cyt c), previously studied by Ikai et al. (Ikai, A., Fish, W. W., & Tanford, C. (1973)…”
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Measurement of the refolding combination reaction between S-peptide and S-protein by Labhardt, Alexander M, Ridge, John A, Lindquist, Robert N, Baldwin, Robert L

“…S-Peptide combines with S-protein during the refolding of ribonuclease S. The kinetics of combination have now been measured by a specific probe, the…”
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Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH by Altmann, S, Labhardt, A M, Senn, H, Wüthrich, K

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Secondary structure in ribonuclease. I. Equilibrium folding transitions seen by amide circular dichroism by Labhardt, A M

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Kinetic circular dichroism shows that the S-peptide alpha -helix of ribonuclease S unfolds fast and refolds slowly by Labhardt, A M

“…It is shown that circular dichroism (CD) can distinguish between the S-peptide and the S-protein fragments of RNase S at 225 nm and 235 nm. The conformational…”
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super(1)H, super(13)C, and super(15)N NMR backbone assignments and secondary structure of human interferon- gamma by Grzesiek, S, Doebeli, H, Gentz, R, Garotta, G, Labhardt, A M, Bax, A

“…super(1)H, super(13)C, and super(15)N NMR assignments of the protein backbone of human interferon- gamma , a homodimer of 31.4 kDa, have been made using the…”
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Secondary structure in ribonuclease. II. Relations between folding kinetics and secondary structure elements by Labhardt, A M

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Template-assembled synthetic proteis with four-helix-bundle topology. Total chemical synthesis and conformational studies by MUTTER, M, TUCHSCHERER, G. G, MILLER, C, ALTMANN, K.-H, CAREY, R. I, WYSS, D. F, LABHARDT, A. M, RIVIER, J. E

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Template-assembled synthetic proteins with four-helix-bundle topology. Total chemical synthesis and conformation studies by Mutter, M, Tuchscherer, G G, Miller, C, Altmann, K-H, Carey, R I, Wyss, D F, Labhardt, A M, Rivier, JE

“…The total chemical synthesis and conformational characterization of three template-assembled synthetic proteins or TASPs (designated T sub(4)-(4 alpha…”
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