Search Results - "Labeta, Mario O"

Toll-Like Receptors 2 and 4 Are Potential Therapeutic Targets in Peritoneal Dialysis-Associated Fibrosis by Raby, Anne-Catherine, Colmont, Chantal S, Kift-Morgan, Ann, Köhl, Jörg, Eberl, Matthias, Fraser, Donald, Topley, Nicholas, Labéta, Mario O

“…Peritoneal dialysis (PD) remains limited by dialysis failure due to peritoneal membrane fibrosis driven by inflammation caused by infections or sterile…”
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Therapeutic Boosting of the Immune Response: Turning to CD14 for Help by Raby, Anne-Catherine, Labéta, Mario O

“…The Toll-like family of immune receptors (TLRs) are critical for an efficient immune response to a variety of microorganisms and other antigens that may cause…”
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Preventing Peritoneal Dialysis-Associated Fibrosis by Therapeutic Blunting of Peritoneal Toll-Like Receptor Activity by Raby, Anne-Catherine, Labéta, Mario O

“…Peritoneal dialysis (PD) is an essential daily life-saving treatment for end-stage renal failure. PD therapy is limited by peritoneal inflammation, which leads…”
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Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection by Cetin, Esra, Mazzarino, Morgane, González-Mateo, Guadalupe T, Kopytina, Valeria, Meran, Soma, Fraser, Donald, López-Cabrera, Manuel, Labéta, Mario O, Raby, Anne-Catherine

“…Bacterial infections and the concurrent inflammation have been associated with increased long-term cardiovascular (CV) risk. In patients receiving peritoneal…”
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Modulation of Neonatal Microbial Recognition: TLR-Mediated Innate Immune Responses Are Specifically and Differentially Modulated by Human Milk by LeBouder, Emmanuel, Rey-Nores, Julia E, Raby, Anne-Catherine, Affolter, Michael, Vidal, Karine, Thornton, Catherine A, Labeta, Mario O

“…The mechanisms controlling innate microbial recognition in the neonatal gut are still to be fully understood. We have sought specific regulatory mechanisms…”
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Targeting the TLR co-receptor CD14 with TLR2-derived peptides modulates immune responses to pathogens by Raby, Anne-Catherine, Holst, Benjamin, Le Bouder, Emmanuel, Diaz, Constantino, Ferran, Edgardo, Conraux, Laurence, Guillemot, Jean-Claude, Coles, Barbara, Kift-Morgan, Ann, Colmont, Chantal S, Szakmany, Tamas, Ferrara, Pascual, Hall, Judith E, Topley, Nicholas, Labéta, Mario O

“…Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsiveness and susceptibility to…”
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Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission by Holst, Benjamin, Szakmany, Tamas, Raby, Anne-Catherine, Hamlyn, Vincent, Durno, Kimberley, Hall, Judith E., Labéta, Mario O.

“…Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been…”
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Therapeutic targeting of chronic kidney disease-associated DAMPs differentially contributing to vascular pathology by Mazzarino, Morgane, Cetin, Esra, Bartosova, Maria, Marinovic, Iva, Ipseiz, Natacha, Hughes, Timothy R., Schmitt, Claus Peter, Ramji, Dipak P., Labéta, Mario O., Raby, Anne-Catherine

“…Chronic Kidney Disease (CKD) is associated with markedly increased cardiovascular (CV) morbidity and mortality. Chronic inflammation, a hallmark of both CKD…”
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Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering by Raby, Anne-Catherine, Le Bouder, Emmanuel, Colmont, Chantal, Davies, James, Richards, Peter, Coles, Barbara, George, Christopher H, Jones, Simon A, Brennan, Paul, Topley, Nicholas, Labeta, Mario O

“…TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to…”
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TLR activation enhances C5a‐induced pro‐inflammatory responses by negatively modulating the second C5a receptor, C5L2 by Raby, Anne‐Catherine, Holst, Benjamin, Davies, James, Colmont, Chantal, Laumonnier, Yves, Coles, Barbara, Shah, Sanjoy, Hall, Judith, Topley, Nicholas, Köhl, Jörg, Morgan, B. Paul, Labéta, Mario O.

“…TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the…”
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Soluble Forms of Toll-Like Receptor (TLR)2 Capable of Modulating TLR2 Signaling Are Present in Human Plasma and Breast Milk by LeBouder, Emmanuel, Rey-Nores, Julia E, Rushmere, Neil K, Grigorov, Martin, Lawn, Stephen D, Affolter, Michael, Griffin, George E, Ferrara, Pascual, Schiffrin, Eduardo J, Morgan, B. Paul, Labeta, Mario O

“…Dysregulation of the initial, innate immune response to bacterial infection may lead to septic shock and death. Toll-like receptors (TLRs) play a crucial role…”
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Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors by Colmont, Chantal S., Raby, Anne-Catherine, Dioszeghy, Vincent, LeBouder, Emmanuel, Foster, Thomas L., Jones, Simon A., Labéta, Mario O., Fielding, Ceri A., Topley, Nicholas

“…Background. Bacterial infection remains a major cause of morbidity and mortality in peritoneal dialysis (PD) patients worldwide. Previous studies have…”
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Cutting Edge: Human B Cell Function Is Regulated by Interaction with Soluble CD14: Opposite Effects on IgG1 and IgE Production by Arias, Mauricio A, Rey Nores, Julia E, Vita, Natalio, Stelter, Felix, Borysiewicz, Leszek K, Ferrara, Pascual, Labeta, Mario O

“…The mechanism(s) controlling activation of naive B cells, their proliferation, Ag receptor affinity maturation, isotype switching, and their fate as memory or…”
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The two soluble forms of the lipopolysaccharide receptor, CD14: characterization and release by normal human monocytes by Durieux, J J, Vita, N, Popescu, O, Guette, F, Calzada-Wack, J, Munker, R, Schmidt, R E, Lupker, J, Ferrara, P, Ziegler-Heitbrock, H W

“…CD14, a glycolipid-anchored membrane glycoprotein, acts as a high affinity lipopolysaccharide receptor on leukocytes. We previously reported that the…”
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Mechanisms of Vascular Pathology Following Peritonitis in Peritoneal Dialysis Patients and Therapeutic Intervention: TH-OR85 by Cetin, Esra, Mazzarino, Morgane, Mateo, Guadalupe T. Gonzalez, Kopytina, Valeria, Bartosova, Maria, Marinovic, Iva, Meran, Soma, Fraser, Donald, Schmitt, Claus Peter, Lopez-Cabrera, Manuel, Labeta, Mario O., Raby, Anne-Catherine

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The lipopolysaccharide co‐receptor CD14 is present and functional in seminal plasma and expressed on spermatozoa by Harris, Claire L., Vigar, Miriam A., Rey Nores, Julia E., Horejsi, Vaclav, Labeta, Mario O., Morgan, B. Paul

“…Summary CD14 is a 54 000‐molecular weight (MW) glycolipid‐anchored membrane glycoprotein, expressed on myeloid cells, which functions as a member of the…”
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Release from a human monocyte-like cell line of two different soluble forms of the lipopolysaccharide receptor, CD14 by Labeta, M O, Durieux, J J, Fernandez, N, Herrmann, R, Ferrara, P

“…Lipopolysaccharide (LPS) stimulates mononuclear phagocytes to synthesize and secrete immunoregulatory and inflammatory molecules such as interleukin-1 (IL-1),…”
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Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14 by Labéta, M O, Vidal, K, Nores, J E, Arias, M, Vita, N, Morgan, B P, Guillemot, J C, Loyaux, D, Ferrara, P, Schmid, D, Affolter, M, Borysiewicz, L K, Donnet-Hughes, A, Schiffrin, E J

“…Little is known about innate immunity to bacteria after birth in the hitherto sterile fetal intestine. Breast-feeding has long been associated with a lower…”
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49 Regulation of TLR mediated responses in the peritoneal cavity by Colmont, Chantal S., Labéta, Mario O., Raby, Anne-Catherine, Coles, Barbara, Jones, Simon A., Topley, Nicholas

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Soluble CD14 acts as a negative regulator of human T cell activation and function by Nores, Julia E. Rey, Bensussan, Armand, Vita, Natalio, Stelter, Felix, Arias, Mauricio A., Jones, Matthew, Lefort, Sylvie, Borysiewicz, Leszek K., Ferrara, Pascual, Labéta, Mario O.

“…T cell activation is controlled by the coordination of stimulatory and negative regulatory signals which are not completely defined. In this study we tested…”
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