Search Results - "Labes, D"

Sample size determination in bioequivalence studies using statistical assurance by Ring, A., Lang, B., Kazaroho, C., Labes, D., Schall, R., Schütz, H.

“…Aims Bioequivalence (BE) trials aim to demonstrate that the 90% confidence interval of the T/R‐ratio of the pharmacokinetic metrics between two formulations…”
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Cytochrome c oxidase deficiency in zidovudine myopathy affects perifascicular muscle fibres and arterial smooth muscle cells by Chariot, P, Le Maguet, F, Authier, F J, Labes, D, Poron, F, Gherardi, R

“…In order to assess the pathogenesis of myopathological alterations induced by zidovudine, we studied muscle samples from 21 patients infected by human…”
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Influence of platelet activating factor antagonists on the protamine sulphate stimulated release of histamine from peritoneal mast cells of rats in vitro by Lohde, C, Bahr, T, Labes, D, Grupe, R

“…The phospholipase (PL)A2 inhibitor p-bromophenacyl bromide (p-BPB), the antagonists of the platelet activating factor (PAF)…”
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Analgesic and antiinflammatory properties of some new salicylic acid derivatives, including QSAR by Langner, A, Hagen, V, Labes, D, Krause, E

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Cytochrome c oxidase deficiencies in the muscle of patients with inflammatory myopathies by CHARIOT, P, RUET, E, AUTHIER, F.-J, LABES, D, PORON, F, GHERARDI, R

“…We studied mitochondrial function in inflammatory myopathies, using cytochrome c oxidase (COX) reaction on muscle biopsy samples from 30 patients (15 with…”
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Potential cardiotonics. 13. Crystal structure, charge distribution and molecular electrostatic potential of 3-cyano-2-(3-diethyl-aminopropylamino)-5-(4-pyridinyl)pyridine (AWD 122-60) by Reck, G, Hagen, V, Labes, D

“…The crystal and molecular structure of the potential cardiotonic agent AWD 122-60 have been determined by X-ray structure analysis. Based on the molecular…”
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Hansch analysis of the inhibitory action of 3- and 4-substituted benzamidines on thrombin, plasmin and trypsin (author's transl) by Labes, D, Hagen, V

“…Using Hansch formalism, the suthors studied quantitatively the relationship between the structure and the inhibitory action of 3- and 4-substituted…”
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Free-Wilson analysis of the inhibitory effect of 4-substituted benzamidines on thrombin, plasmin and trypsin (author's transl) by Labes, D, Hagen, V

“…Using the Fujita-Ban model, the authors studied the quantitative structure-inhibitory activity relationships of a series of 4-amidinophenyl compounds with…”
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Pharmacokinetics and biotransformation of 3-cyan-2-morpholino-5-(pyrid-4-yl)pyridine (AWD 122-14) in the rat by Vagaday, M, Kunter, U, Labes, D, Hagen, V, Böhme, B, Franke, P

“…A sensitive isocratic HPLC method for the analysis of AWD 122-14 (1) in plasma and urine was developed. The extraction was processed on-line on a short column…”
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Potential cardiotonic agents. 4. Synthesis, cardiovascular activity, molecular and crystal structure of 5-phenyl- and 4-(4-pyridinyl)-substituted 2(1H)-pyridinethiones by Hagen, V, Rumler, A, Reck, G, Hagen, A, Labes, D, Heer, S

“…Cyclisation of the vinylogous amidinium salt 1 or the 4-ethoxy- and 4-morpholino-3-butene-2-ones, respectively, 4 and 6 with cyano-thioacetamide yielded the…”
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Quantum chemical studies on substituted benzamidines as inhibitors of the serine proteinases trypsin and thrombin by Henkel, H J, Labes, D, Hagen, V

“…Substituted benzamidines are competitive inhibitors of trypsin and thrombin. The aim of this work is to find an interpretation for the relation between…”
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Synthesis and analgesic effect of 2-aryliminomethylquinolines by Hagen, V, Dove, B, Morgenstern, E, Labes, D, Göres, E, Tomaschewski, G, Geisler, G, Franke, C

“…2-Aryliminomethylquinolines were synthesized by the condensation of quinoline-2-carbaldehyde with the corresponding anilines. The compounds were evaluated for…”
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Antiviral thiosemicarbazone and related compounds. III. Quantitative relationships between structure and antiviral activity of isantin-beta-isothio-semicarbazone against mengo virus by Franke, R, Labes, D, Tonew, M, Zschiesche, W, Heinisch, L

“…The virostatic activity of isatin-beta-isothiosemicarbazones can be described quantitatively by hydrophobic, electronic, and steric substituent constants using…”
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