A new 2S albumin from Jatropha curcas L. seeds and assessment of its allergenic properties

Significant effort has been made world-wide to boost biofuels with the expectation of a positive contribution to renewable fuel and greenhouse gas reduction. Jatropha curcas L. has proved to be an opportunistic crop in tropical areas, particularly in unfavorable environments. For this reason, analys...

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Published in:	Peptides (New York, N.Y. : 1980) Vol. 30; no. 12; pp. 2103 - 2107
Main Authors:	Maciel, Fábio Menezes, Laberty, Mariana Agra, Oliveira, Natália Deus, Felix, Shayany Pinto, Soares, Alexandra Martins dos Santos, Verícimo, Maurício Afonso, Machado, Olga Lima Tavares
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-12-2009 Elsevier
Subjects:	2S albumin Albumins - immunology Albumins - isolation & purification Allergens - immunology Allergens - isolation & purification Allergy Animals Biological and medical sciences Chromatography, High Pressure Liquid Electrophoresis, Polyacrylamide Gel Female Fundamental and applied biological sciences. Psychology Jat c 1 Jatropha - chemistry Jatropha - immunology Jatropha curcas Mast Cells - cytology Mast Cells - immunology Mice Mice, Inbred BALB C Physic nut Plant Proteins - chemistry Plant Proteins - immunology Plant Proteins - isolation & purification Pollen - immunology Pollen - metabolism Rats Ricinus communis Ricinus communis - immunology Seeds - chemistry Seeds - immunology Vertebrates: endocrinology Allergy Physic nut 2S albumin Jat c 1 Jatropha curcas PCA PEC Immunopathology Albumin
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Summary:	Significant effort has been made world-wide to boost biofuels with the expectation of a positive contribution to renewable fuel and greenhouse gas reduction. Jatropha curcas L. has proved to be an opportunistic crop in tropical areas, particularly in unfavorable environments. For this reason, analyses of toxicity and allergy caused by its seeds and pollen are necessary. A 12 kDa, allergenic 2S albumin, denoted Jat c 1, was isolated from Physic nut ( J. curcas) seeds. Jat c 1 binds IgE attached to rat mast cells, inducing histamine release. It also showed strong cross-reactivity with the major allergens from castor bean, Ric c 1 and Ric c 3.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0196-9781 1873-5169
DOI:	10.1016/j.peptides.2009.08.008