Search Results - "Labella, Kyle"

Telomeres: history, health, and hallmarks of aging by Chakravarti, Deepavali, LaBella, Kyle A., DePinho, Ronald A.

“…The escalating social and economic burden of an aging world population has placed aging research at center stage. The hallmarks of aging comprise diverse…”
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Oscillation steers differentiation by LaBella, Kyle A, Reyes, Efren A, Vermeulen, Louis

“…The differentiation trajectories defining enteroendocrine (EE) cell heterogeneity remain obscure. In this issue of Cell Stem Cell, Singh et al. map the…”
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Histone demethylase KDM5D upregulation drives sex differences in colon cancer by Li, Jiexi, Lan, Zhengdao, Liao, Wenting, Horner, James W., Xu, Xueping, Liu, Jielin, Yoshihama, Yohei, Jiang, Shan, Shim, Hong Seok, Slotnik, Max, LaBella, Kyle A., Wu, Chang-Jiun, Dunner, Kenneth, Hsu, Wen-Hao, Lee, Rumi, Khanduri, Isha, Terranova, Christopher, Akdemir, Kadir, Chakravarti, Deepavali, Shang, Xiaoying, Spring, Denise J., Wang, Y. Alan, DePinho, Ronald A.

“…Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular and genetic bases of such sex differences are ill-defined and…”
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Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy by Wrighton, Paul J, Shwartz, Arkadi, Heo, Jin-Mi, Quenzer, Eleanor D, LaBella, Kyle A, Harper, J Wade, Goessling, Wolfram

“…Mitophagy, the selective recycling of mitochondria through autophagy, is a crucial metabolic process induced by cellular stress, and defects are linked to…”
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Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer by Han, Jincheng, Xu, Jiaqian, Liu, Yonghong, Liang, Shaoheng, LaBella, Kyle A, Chakravarti, Deepavali, Spring, Denise J, Xia, Yan, DePinho, Ronald A

“…Activating KRAS mutations (KRAS*) in pancreatic ductal adenocarcinoma (PDAC) drive anabolic metabolism and support tumor maintenance. KRAS* inhibitors show…”
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Telomere dysfunction activates YAP1 to drive tissue inflammation by Chakravarti, Deepavali, Hu, Baoli, Mao, Xizeng, Rashid, Asif, Li, Jiexi, Li, Jun, Liao, Wen-ting, Whitley, Elizabeth M., Dey, Prasenjit, Hou, Pingping, LaBella, Kyle A., Chang, Andrew, Wang, Guocan, Spring, Denise J., Deng, Pingna, Zhao, Di, Liang, Xin, Lan, Zhengdao, Lin, Yiyun, Sarkar, Sharmistha, Terranova, Christopher, Deribe, Yonathan Lissanu, Blutt, Sarah E., Okhuysen, Pablo, Zhang, Jianhua, Vilar, Eduardo, Nielsen, Ole Haagen, Dupont, Andrew, Younes, Mamoun, Patel, Kalyani R., Shroyer, Noah F., Rai, Kunal, Estes, Mary K., Wang, Y. Alan, Bertuch, Alison A., DePinho, Ronald A.

“…Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how telomere dysfunction…”
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Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer by Lee, Rumi, Li, Jiexi, Li, Jun, Wu, Chang-Jiun, Jiang, Shan, Hsu, Wen-Hao, Chakravarti, Deepavali, Chen, Peiwen, LaBella, Kyle A, Li, Jing, Spring, Denise J, Zhao, Di, Wang, Y Alan, DePinho, Ronald A

“…Inactivation of adenomatous polyposis coli (APC) is common across many cancer types and serves as a critical initiating event in most sporadic colorectal…”
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AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase by Yoshihama, Yohei, LaBella, Kyle A., Kim, Eiru, Bertolet, Lori, Colic, Medina, Li, Jiexi, Shang, Xiaoying, Wu, Chang-Jiun, Spring, Denise J., Wang, Y. Alan, Hart, Traver, DePinho, Ronald A.

“…Prostate cancer is a leading cause of cancer-related mortality in men. The widespread use of androgen receptor (AR) inhibitors has generated an increased…”
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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer by LaBella, Kyle A, Hsu, Wen-Hao, Li, Jiexi, Qi, Yutao, Liu, Yonghong, Liu, Jingjing, Wu, Chia-Chin, Liu, Yang, Song, Zingzhi, Lin, Yiyun, Blecher, Jonathan M, Jiang, Shan, Shang, Xiaoying, Han, Jincheng, Spring, Denise J, Zhang, Jianhua, Xia, Yan, DePinho, Ronald A

“…Telomere dynamics are linked to aging hallmarks, and age-associated telomere loss fuels the development of epithelial cancers. In Apc-mutant mice, the onset of…”
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Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes by Chaturantabut, Saireudee, Shwartz, Arkadi, Evason, Kimberley J., Cox, Andrew G., Labella, Kyle, Schepers, Arnout G., Yang, Song, Acuña, Mariana, Houvras, Yariv, Mancio-Silva, Liliana, Romano, Shannon, Gorelick, Daniel A., Cohen, David E., Zon, Leonard I., Bhatia, Sangeeta N., North, Trista E., Goessling, Wolfram

“…Patients with cirrhosis are at high risk for hepatocellular carcinoma (HCC) and often have increased serum levels of estrogen. It is not clear how estrogen…”
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Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood by Weeks, Olivia, Bossé, Gabriel D, Oderberg, Isaac M, Akle, Sebastian, Houvras, Yariv, Wrighton, Paul J, LaBella, Kyle, Iversen, Isabelle, Tavakoli, Sahar, Adatto, Isaac, Schwartz, Arkadi, Kloosterman, Daan, Tsomides, Allison, Charness, Michael E, Peterson, Randall T, Steinhauser, Matthew L, Fazeli, Pouneh K, Goessling, Wolfram

“…Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its…”
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Abstract 1073: PRMT5 inhibition synergizes with a natural small molecule compound to kill MTAP- deleted cells and suppress tumor growth by Barekatain, Yasaman, LaBella, Kyle, Sugimoto, Hikaru, Harris, Kristen, Khadka, Sunada, Muller, Florian, Kalluri, Raghu

“…Abstract Homozygous deletion of MTAP occurs in about 15% of all human cancers, such as glioblastoma, pancreatic cancer, mesothelioma, urothelial bladder…”
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Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development by Chaturantabut, Saireudee, Shwartz, Arkadi, Garnaas, Maija K., LaBella, Kyle, Li, Chia‐Cheng, Carroll, Kelli J., Cutting, Claire C., Budrow, Nadine, Palaria, Amrita, Gorelick, Daniel A., Tremblay, Kimberly D., North, Trista E., Goessling, Wolfram

“…Background and Aims During liver development, bipotent progenitor cells differentiate into hepatocytes and biliary epithelial cells to ensure a functional…”
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Estrogen acts via estrogen receptor 2b to regulate hepatobiliary fate during vertebrate development by Chaturantabut, Saireudee, Shwartz, Arkadi, Garnaas, Maija K., LaBella, Kyle, Li, Chia-Cheng, Carroll, Kelli J., Cutting, Claire C., Budrow, Nadine, Palaria, Amrita, Gorelick, Daniel A., Tremblay, Kimberly D., North, Trista E., Goessling, Wolfram

“…During liver development bipotent progenitor cells differentiate into hepatocytes and biliary epithelial cells (BECs) to ensure a functional liver required to…”
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Abstract IA20: Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer by Han, Jincheng, Xu, Jiaqian, Liu, Yonghong, Liang, Shaoheng, LaBella, Kyle A., Chakravarti, Deepavali, Spring, Denise J., Xia, Yan, DePinho, Ronald A.

“…Abstract Oncogenic KRAS (KRAS*) is a signature mutation in pancreatic ductal adenocarcinoma (PDAC). While genetic extinction or pharmacological inhibition of…”
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Abstract 3515: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer by Li, Jiexi, Lan, Zhengdao, Liao, Wenting, Liu, Jielin, Jiang, Shan, Shim, Hong Seok, Slotnik, Max, LaBella, Kyle A., Hsu, Wen-Hao, Shang, Xiaoying, Spring, Denise, Wang, Y Alan, DePinho, Ronald A.

“…Abstract Gender exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular genetic bases of such sex differences are ill-defined…”
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Abstract IA014: Synthetic essentiality identifies TDO2 as a key target in APC-deficient CRC by Lee, Rumi, Li, Jiexi, Li, Jun, Wu, Chang-Jiun, Jiang, Shan, Hsu, Wen-Hao, Chakravarti, Deepavali, Chen, Peiwen, LaBella, Kyle A., Li, Jing, Spring, Denise J., Zhao, Di, Wang, Y. Alan, DePinho, Ronald A.

“…Abstract Loss of adenomatous polyposis coli (APC) is considered a critical initiating event in colorectal cancer (CRC), where it occurs in 90% of sporadic…”
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Abstract PR011: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer by Li, Jiexi, Lan, Zhengdao, Liao, Wenting, Horner, James W., Liu, Jielin, Jiang, Shan, Shim, Hong S., Slotnik, Max, LaBella, Kyle A., Hsu, Wen-Hao, Spring, Denise J., Wang, Y. Alan, DePinho, Ronald A.

“…Abstract Gender exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular genetic bases of such sex differences are ill-defined…”
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