Search Results - "Labbé, Céline M"

MTiOpenScreen: a web server for structure-based virtual screening by Labbé, Céline M, Rey, Julien, Lagorce, David, Vavruša, Marek, Becot, Jérome, Sperandio, Olivier, Villoutreix, Bruno O, Tufféry, Pierre, Miteva, Maria A

“…Open screening endeavors play and will play a key role to facilitate the identification of new bioactive compounds in order to foster innovation and to improve…”
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iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein–protein interactions by Labbé, Céline M., Laconde, Guillaume, Kuenemann, Mélaine A., Villoutreix, Bruno O., Sperandio, Olivier

“…The development of small molecule drugs targeting protein–protein interactions (PPI) represents a major challenge, in part owing to the misunderstanding of the…”
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Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C930 by Louet, Maxime, Labbé, Céline M, Fagnen, Charline, Aono, Cassiano M, Homem-de-Mello, Paula, Villoutreix, Bruno O, Miteva, Maria A

“…Cytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated drugs. The allelic variant CYP2C9*30 (A477T) is associated to diminished…”
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Which Three-Dimensional Characteristics Make Efficient Inhibitors of Protein–Protein Interactions? by Kuenemann, Mélaine A, Bourbon, Laura M. L, Labbé, Céline M, Villoutreix, Bruno O, Sperandio, Olivier

“…The specific properties of protein–protein interactions (PPI) (flat, large and hydrophobic) make them harder to tackle with low-molecular-weight compounds…”
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One hundred thousand mouse clicks down the road: selected online resources supporting drug discovery collected over a decade by Villoutreix, Bruno O., Lagorce, David, Labbé, Céline M., Sperandio, Olivier, Miteva, Maria A.

“…•There are many in silico resources and databases that can assist drug discovery; yet it is almost impossible to track all these new services.•We provide a…”
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In silico design of low molecular weight protein–protein interaction inhibitors: Overall concept and recent advances by Kuenemann, Mélaine A., Sperandio, Olivier, Labbé, Céline M., Lagorce, David, Miteva, Maria A., Villoutreix, Bruno O.

“…Protein–protein interactions (PPIs) are carrying out diverse functions in living systems and are playing a major role in the health and disease states. Low…”
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Compartment-specific and ELAVL1-coordinated regulation of intronic polyadenylation isoforms by doxorubicin by Chakraborty, Alina, Cadix, Mandy, Relier, Sébastien, Taricco, Nicolò, Alaeitabar, Tina, Devaux, Alexandre, Labbé, Céline M, Martineau, Sylvain, Heneman-Masurel, Amélie, Gestraud, Pierre, Inga, Alberto, Servant, Nicolas, Vagner, Stéphan, Dutertre, Martin

“…Intronic polyadenylation (IPA) isoforms, which contain alternative last exons, are widely regulated in various biological processes and by many factors…”
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AMMOS2: a web server for protein-ligand-water complexes refinement via molecular mechanics by Labbé, Céline M, Pencheva, Tania, Jereva, Dessislava, Desvillechabrol, Dimitri, Becot, Jérôme, Villoutreix, Bruno O, Pajeva, Ilza, Miteva, Maria A

“…AMMOS2 is an interactive web server for efficient computational refinement of protein-small organic molecule complexes. The AMMOS2 protocol employs…”
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Differential Effects on the Translation of Immune-Related Alternatively Polyadenylated mRNAs in Melanoma and T Cells by eIF4A Inhibition by Biswas, Biswendu, Guemiri, Ramdane, Cadix, Mandy, Labbé, Céline M, Chakraborty, Alina, Dutertre, Martin, Robert, Caroline, Vagner, Stéphan

“…Targeting the translation initiation complex eIF4F, which binds the 5' cap of mRNAs, is a promising anti-cancer approach. Silvestrol, a small molecule…”
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Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors by Kuenemann, Mélaine A., Labbé, Céline M., Cerdan, Adrien H., Sperandio, Olivier

“…Protein-protein interactions (PPIs) play vital roles in life and provide new opportunities for therapeutic interventions. In this large data analysis, 3,300…”
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iPPI-DB: an online database of modulators of protein-protein interactions by Labbé, Céline M, Kuenemann, Mélaine A, Zarzycka, Barbara, Vriend, Gert, Nicolaes, Gerry A F, Lagorce, David, Miteva, Maria A, Villoutreix, Bruno O, Sperandio, Olivier

“…In order to boost the identification of low-molecular-weight drugs on protein-protein interactions (PPI), it is essential to properly collect and annotate…”
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An exploration of the 3D chemical space has highlighted a specific shape profile for the compounds intended to inhibit protein-protein interactions by Kuenemann, Mélaine A, Bourbon, Laura ML, Labbé, Céline M, Villoutreix, Bruno O, Sperandio, Olivier

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