Search Results - "Labbadia, John"

Huntington's disease: underlying molecular mechanisms and emerging concepts by Labbadia, John, Morimoto, Richard I.

“…•Spotlight on key advances in our understanding of molecular dysfunction and HD.•Description of novel pathways influencing intracellular levels of mutant…”
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Distinct patterns of proteostasis network gene expression are associated with different prognoses in melanoma patients by Wellman, Rachel, Jacobson, Daniel, Secrier, Maria, Labbadia, John

“…The proteostasis network (PN) is a collection of protein folding and degradation pathways that spans cellular compartments and acts to preserve the integrity…”
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Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease by Labbadia, John, Cunliffe, Helen, Weiss, Andreas, Katsyuba, Elena, Sathasivam, Kirupa, Seredenina, Tamara, Woodman, Ben, Moussaoui, Saliha, Frentzel, Stefan, Luthi-Carter, Ruth, Paganetti, Paolo, Bates, Gillian P

“…Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that…”
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Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders by Carnemolla, Alisia, Labbadia, John P, Lazell, Hayley, Neueder, Andreas, Moussaoui, Saliha, Bates, Gillian P

“…Ageing is associated with the reduced performance of physiological processes and has been proposed as a major risk factor for disease. An age-related decline…”
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Suppression of protein aggregation by chaperone modification of high molecular weight complexes by LABBADIA, John, NOVOSELOV, Sergey S, BETT, John S, WEISS, Andreas, PAGANETTI, Paolo, BATES, Gillian P, CHEETHAM, Michael E

“…Protein misfolding and aggregation are associated with many neurodegenerative diseases, including Huntington's disease. The cellular machinery for maintaining…”
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Mitochondrial clearance and increased HSF-1 activity are coupled to promote longevity in fasted Caenorhabditis elegans by Tataridas-Pallas, Nikolaos, Aman, Yahyah, Williams, Rhianna, Chapman, Hannah, Cheng, Kevin J.H., Gomez-Paredes, Casandra, Bates, Gillian P., Labbadia, John

“…Fasting has emerged as a potent means of preserving tissue function with age in multiple model organisms. However, our understanding of the relationship…”
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The importance of long-lived proteins: Not just nuclear anymore by Erinjeri, Annmary Paul, Labbadia, John

“…The significance of mitochondrial long-lived proteins (mitoLLPs) to tissue health has remained mysterious for over a decade. In this issue of Developmental…”
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A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse by Williams, Rhianna, Laskovs, Mihails, Williams, Rebecca I., Mahadevan, Ananya, Labbadia, John

“…The loss of protein homeostasis (proteostasis) is a primary driver of age-related tissue dysfunction. Recent studies have revealed that the failure of…”
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Autophagy in healthy aging and disease by Aman, Yahyah, Schmauck-Medina, Tomas, Hansen, Malene, Morimoto, Richard I, Simon, Anna Katharina, Bjedov, Ivana, Palikaras, Konstantinos, Simonsen, Anne, Johansen, Terje, Tavernarakis, Nektarios, Rubinsztein, David C, Partridge, Linda, Kroemer, Guido, Labbadia, John, Fang, Evandro F

“…Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via…”
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Proteostasis and longevity: when does aging really begin? by Labbadia, John, Morimoto, Richard I

“…Aging is a complex process regulated by multiple cellular pathways, including the proteostasis network. The proteostasis network consists of molecular…”
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Loss of MTCH-1 suppresses age-related proteostasis collapse through the inhibition of programmed cell death factors by Aman, Yahyah, Erinjeri, Annmary Paul, Tataridas-Pallas, Nikolaos, Williams, Rhianna, Wellman, Rachel, Chapman, Hannah, Labbadia, John

“…The age-related loss of protein homeostasis (proteostasis) is at the heart of numerous neurodegenerative diseases. Therefore, finding ways to preserve proteome…”
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Proteostasis and longevity: when does aging really begin? by Labbadia, John, Morimoto, Richard I

“…Aging is a complex process regulated by multiple cellular pathways, including the proteostasis network. The proteostasis network consists of molecular…”
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