Search Results - "Laband, Kimberley"
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Chromosome segregation occurs by microtubule pushing in oocytes
Published in Nature communications (14-11-2017)“…During cell division, spindle microtubules ensure an equal repartition of chromosomes between the two daughter cells. While the kinetochore-dependent…”
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Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes
Published in Nature communications (07-07-2023)“…During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend…”
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Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes
Published in Development (Cambridge) (01-05-2017)“…In most species, oocytes lack centrosomes. Accurate meiotic spindle assembly and chromosome segregation - essential to prevent miscarriage or developmental…”
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Inhibition of Rac by the GAP Activity of Centralspindlin Is Essential for Cytokinesis
Published in Science (American Association for the Advancement of Science) (05-12-2008)“…During cytokinesis, the guanosine triphosphatase (GTPase) RhoA orchestrates contractile ring assembly and constriction. RhoA signaling is controlled by the…”
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Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly
Published in eLife (17-02-2023)“…During cell division, chromosome segregation is orchestrated by a microtubule-based spindle. Interaction between spindle microtubules and kinetochores is…”
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A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue
Published in Cell (29-04-2011)“…High-content screening for gene profiling has generally been limited to single cells. Here, we explore an alternative approach—profiling gene function by…”
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Kinetochore components are required for central spindle assembly
Published in Nature cell biology (01-05-2015)“…Using C. elegans zygotes, Dumont and colleagues find that kinetochore proteins, including KNL-1, participate in assembly of central spindle microtubules for…”
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Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes
Published in Journal of cell science (15-05-2017)Get full text
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9
High-Resolution Temporal Analysis Reveals a Functional Timeline for the Molecular Regulation of Cytokinesis
Published in Developmental cell (28-07-2014)“…To take full advantage of fast-acting temperature-sensitive mutations, thermal control must be extremely rapid. We developed the Therminator, a device capable…”
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Kinetochore components are required for central spindle assembly
Published in Nature cell biology (01-07-2015)Get full text
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Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7MCAK prevents chromosome segregation and cytokinesis defects in oocytes
Published in Development (Cambridge) (01-01-2017)“…In most species, oocytes lack centrosomes. Accurate meiotic spindle assembly and chromosome segregation -essential to prevent miscarriage or developmental…”
Get full text
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12
Live imaging of C. elegans oocytes and early embryos
Published in Methods in cell biology (2018)“…Caenorhabditis elegans is a self-fertilizing hermaphroditic worm. A single C. elegans worm therefore produces both male and female gametes that fuse to…”
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Book Chapter Journal Article -
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Corrigenda: Kinetochore components are required for central spindle assembly
Published in Nature cell biology (01-07-2015)Get full text
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Erratum: Corrigenda: Kinetochore components are required for central spindle assembly
Published in Nature cell biology (30-06-2015)Get full text
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Correction: Corrigenda: Kinetochore components are required for central spindle assembly
Published in Nature cell biology (2015)“…Nat. Cell Biol. 17, 697–705 (2015); published online 13 April 2015; corrected after print 8 June 2015 In the version of this Letter originally published, the…”
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