Search Results - "Laat, Paul"

Algorithmic Decision-Making Based on Machine Learning from Big Data: Can Transparency Restore Accountability? by de Laat, Paul B.

“…Decision-making assisted by algorithms developed by machine learning is increasingly determining our lives. Unfortunately, full opacity about the process is…”
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Companies Committed to Responsible AI: From Principles towards Implementation and Regulation? by de Laat, Paul B.

“…The term ‘responsible AI’ has been coined to denote AI that is fair and non-biased, transparent and explainable, secure and safe, privacy-proof, accountable,…”
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The disciplinary power of predictive algorithms: a Foucauldian perspective by de Laat, Paul B.

“…Big Data are increasingly used in machine learning in order to create predictive models. How are predictive practices that use such models to be situated? In…”
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Algorithmic decision-making employing profiling: will trade secrecy protection render the right to explanation toothless? by de Laat, Paul B.

“…Algorithmic decision-making based on profiling may significantly affect people’s destinies. As a rule, however, explanations for such decisions are lacking…”
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The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders by Janssen, Mirian C.H., Koene, Saskia, Laat, Paul, Hemelaar, Pleun, Pickkers, Peter, Spaans, Edwin, Beukema, Rypko, Beyrath, Julien, Groothuis, Jan, Verhaak, Chris, Smeitink, Jan

“…KH176 is a potent intracellular reduction–oxidation‐modulating compound developed to treat mitochondrial disease. We studied tolerability, safety,…”
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Copyright or copyleft?: An analysis of property regimes for software development by de Laat, Paul B

“…Two property regimes for software development may be distinguished. Within corporations, on the one hand, a Private Regime obtains which excludes all outsiders…”
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Clinical features and heteroplasmy in blood, urine and saliva in 34 Dutch families carrying the m.3243A > G mutation by de Laat, Paul, Koene, Saskia, van den Heuvel, Lambert P. W. J., Rodenburg, Richard J. T., Janssen, Mirian C. H., Smeitink, Jan A. M.

“…The m.3243A > G mutation has become known as the MELAS mutation. However, many other clinical phenotypes associated with this mutation have been described,…”
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Profiling vandalism in Wikipedia: A Schauerian approach to justification by de Laat, Paul B.

“…In order to fight massive vandalism the English-language Wikipedia has developed a system of surveillance which is carried out by humans and bots, supported by…”
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The use of software tools and autonomous bots against vandalism: eroding Wikipedia’s moral order? by de Laat, Paul B.

“…English-language Wikipedia is constantly being plagued by vandalistic contributions on a massive scale. In order to fight them its volunteer contributors…”
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Governance of open source software: state of the art by de Laat, Paul B

“…In this overview of governance mechanisms developed within open source software (OSS) circles, three types of governance are studied: "spontaneous" governance,…”
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Identifying trajectories of fatigue in patients with primary mitochondrial disease due to the m.3243A > G variant by Klein, Inge‐Lot, Verhaak, Christianne M., Smeitink, Jan A. M., Laat, Paul, Janssen, Mirian C. H., Custers, José A. E.

“…Severe fatigue is a common complaint in patients with primary mitochondrial disease. However, less is known about the course of fatigue over time. This…”
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Mitochondrial Retinal Dystrophy Associated with the m.3243A>G Mutation by de Laat, Paul, MD, Smeitink, Jan A.M., MD, PhD, Janssen, Mirian C.H., MD, PhD, Keunen, Jan E.E., MD, PhD, Boon, Camiel J.F., MD, PhD

“…Objective To describe the spectrum of retinal abnormalities associated with the m.3243A>G mutation in the mitochondrial MTTL1 gene and to analyze putative…”
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How can contributors to open-source communities be trusted? On the assumption, inference, and substitution of trust by de Laat, Paul B.

“…Open-source communities that focus on content rely squarely on the contributions of invisible strangers in cyberspace. How do such communities handle the…”
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One mutation, three phenotypes: novel metabolic insights on MELAS, MIDD and myopathy caused by the m.3243A > G mutation by Esterhuizen, Karien, Lindeque, J. Zander, Mason, Shayne, van der Westhuizen, Francois H., Rodenburg, Richard J., de Laat, Paul, Smeitink, Jan A. M., Janssen, Mirian C. H., Louw, Roan

“…Introduction The m.3243A > G mitochondrial DNA mutation is one of the most common mitochondrial disease-causing mutations, with a carrier rate as high as…”
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From open-source software to Wikipedia: ‘Backgrounding’ trust by collective monitoring and reputation tracking by de Laat, Paul B.

“…Open-content communities that focus on co-creation without requirements for entry have to face the issue of institutional trust in contributors. This research…”
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A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS) by Esterhuizen, Karien, Lindeque, J Zander, Mason, Shayne, van der Westhuizen, Francois H, Suomalainen, Anu, Hakonen, Anna H, Carroll, Christopher J, Rodenburg, Richard J, de Laat, Paul B, Janssen, Mirian C H, Smeitink, Jan A M, Louw, Roan

“…We used a comprehensive metabolomics approach to study the altered urinary metabolome of two mitochondrial myopathy, encephalopathy lactic acidosis and stroke…”
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Coercion or empowerment? Moderation of content in Wikipedia as ‘essentially contested’ bureaucratic rules by de Laat, Paul B.

“…In communities of user-generated content, systems for the management of content and/or their contributors are usually accepted without much protest. Not so,…”
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Online diaries: Reflections on trust, privacy, and exhibitionism by de Laat, Paul B.

“…Trust between transaction partners in cyberspace has come to be considered a distinct possibility. In this article the focus is on the conditions for its…”
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Open Source Production of Encyclopedias: Editorial Policies at the Intersection of Organizational and Epistemological Trust by de Laat, Paul B.

“…The ideas behind open source software are currently applied to the production of encyclopedias. A sample of six English text-based, neutral-point-of-view,…”
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Trusting virtual trust by DE LAAT, Paul B

“…Can trust evolve on the Internet between virtual strangers? Recently, Pettit answered this question in the negative. Focusing on trust in the sense of…”
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