Search Results - "Laakso, Sini M."

Early clinical features of new-onset refractory status epilepticus (NORSE) in adults by Haanpää, Anna, Laakso, Sini M, Kinnunen, Antti, Kämppi, Leena, Forss, Nina

“…The aim of this study was to identify early clinical features of patients with new-onset refractory status epilepticus (NORSE) that could direct the treatment…”
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Complete remission of central nervous system manifestations of IgG4-related disease with rituximab – a case report by Sihvonen, Aleksi J., Laakso, Sini M., Tynninen, Olli, Saaren-Seppälä, Heikki, Löfberg, Mervi

“…IgG4-related disease (IgG4-RD) is an emerging immune-mediated chronic fibrotic disease characterized by tumour-like mass formation. Reports of brain…”
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Hemophagocytic lymphohistiocytosis in an adult patient with super‐refractory status epilepticus by Haanpää, Anna, Kämppi, Leena, Kantonen, Jonas, Myllykangas, Liisa, Laakso, Sini M., Forss, Nina

“…This case report presents a 38‐year‐old male patient who, after a febrile infection, developed super‐refractory status epilepticus and multiorgan failure, and…”
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Effects of a Digital Care Pathway for Multiple Sclerosis: Observational Study by Vesinurm, Märt, Maunula, Anna, Olli, Päivi, Lillrank, Paul, Ijäs, Petra, Torkki, Paulus, Mäkitie, Laura, Laakso, Sini M

“…Helsinki University Hospital has developed a digital care pathway (DCP) for people with multiple sclerosis (MS) to improve the care quality. DCP was designed…”
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Intensive care due to myasthenia gravis: Risk factors and prognosis by Myllynen, Chris, Tuulasvaara, Anni, Atula, Sari, Laakso, Sini M.

“…Background and purpose Exacerbation of myasthenia gravis (MG) with respiratory failure requires intensive care. We aimed to study the risk factors for…”
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Comorbidities worsen the prognosis of generalized myasthenia gravis post-thymectomy by Laakso, Sini M., Myllynen, Chris, Strbian, Daniel, Atula, Sari

“…The effect of comorbidities on the prognosis of myasthenia gravis (MG) remains unclear. In particular, the role of other autoimmune diseases (AD) is…”
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Trigeminal neuralgia in multiple sclerosis: Prevalence and association with demyelination by Laakso, Sini M., Hekali, Oskari, Kurdo, Goran, Martola, Juha, Sairanen, Tiina, Atula, Sari

“…Objectives The association of trigeminal neuralgia (TN) with multiple sclerosis (MS) is still widely unaddressed in larger, systematical clinical series. In…”
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Ectopic germinal centers in the thymus accurately predict prognosis of myasthenia gravis after thymectomy by Sarkkinen, Joona, Dunkel, Johannes, Tuulasvaara, Anni, Huuskonen, Antti, Atula, Sari, Kekäläinen, Eliisa, Laakso, Sini M.

“…The ability of thymic histopathology to predict the long-term impact of thymectomy in non-thymomatous myasthenia gravis (NTMG) is mainly uncharted. We applied…”
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Exploring JC Polyomavirus Sequences and Human Gene Expression in Brain Tissue of Patients With Progressive Multifocal Leukoencephalopathy by Honkimaa, Anni, Laine, Pia, Suppula, Joni, Tynninen, Olli, Saarela, Mika, Laakso, Sini M, Hetemäki, Iivo, Liimatainen, Hanna, Auvinen, Petri, Auvinen, Eeva

“…Abstract Progressive multifocal leukoencephalopathy (PML) is a rare neurological condition associated with reactivation of dormant JC polyomavirus (JCPyV). In…”
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Incidental demyelination in magnetic resonance imaging and 10‐year risk of multiple sclerosis: A data lake cohort study by Maunula, Anna, Martola, Juha, Atula, Sari, Laakso, Sini M., Tienari, Pentti J.

“…Background and purpose There is an absence of data from large population‐based cohort studies on the incidence of radiologically isolated syndrome (RIS). The…”
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A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis by Myllynen, Chris, Sarkkinen, Joona, Atula, Sari, Tienari, Pentti, Kekäläinen, Eliisa, Laakso, Sini M.

“…•The κ/λ ratio is significantly elevated in patients with late-onset myasthenia gravis (LOMG).•Detected even after a decade of follow-up, these results suggest…”
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Cervical lymph node diameter reflects disease progression in multiple sclerosis by Tuulasvaara, Anni, Kurdo, Goran, Martola, Juha, Laakso, Sini M.

“…•Cervical lymph nodes can be measured from multiple sclerosis follow-up head MRIs.•Smaller lymph node diameter predicts disease progression during…”
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High Epstein-Barr virus capsid antigen IgG level associates with the carriership of CD8+ T cell somatic mutations in the STAT3 SH2 domain by Lehikoinen, Joonas, Valori, Miko, Jääskeläinen, Anne J., Laakso, Sini M., Arstila, T. Petteri, Tienari, Pentti J.

“…High carrier prevalence of STAT3 SH2 domain somatic mutations was recently discovered in CD8+ T cells. We found these low-allele-fraction clones in 26% of…”
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Multiple sclerosis in Finland 2018—Data from the national register by Laakso, Sini M., Viitala, Matias, Kuusisto, Hanna, Sarasoja, Taneli, Hartikainen, Päivi, Atula, Sari, Tienari, Pentti J., Soilu‐Hänninen, Merja

“…Objectives Finland is a high‐risk multiple sclerosis (MS) region, but a national MS register has not existed until 2014. In this paper, we present the Finnish…”
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Clinically relevant increases in serum neurofilament light chain and glial fibrillary acidic protein in patients with Susac syndrome by Plantone, Domenico, Sabatelli, Eleonora, Locci, Sara, Marrodan, Mariano, Laakso, Sini M, Mateen, Farrah J, Feresiadou, Amalia, Buelens, Tom, Bianco, Assunta, Fiol, Marcela P, Correale, Jorge, Tienari, Pentti, Calabresi, Paolo, De Stefano, Nicola, Iorio, Raffaele

“…Serum levels of neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising neuro-axonal damage and astrocytic activation…”
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Epstein-Barr Virus in the Cerebrospinal Fluid and Blood Compartments of Patients With Multiple Sclerosis and Controls by Lehikoinen, Joonas, Nurmi, Katariina, Ainola, Mari, Clancy, Jonna, Nieminen, Janne K, Jansson, Lilja, Vauhkonen, Hanna, Vaheri, Antti, Smura, Teemu, Laakso, Sini M, Eklund, Kari K, Tienari, Pentti J

“…Epstein-Barr virus (EBV) infection is a major risk factor of multiple sclerosis (MS). We examined the presence of EBV DNA in the CSF and blood of patients with…”
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Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3+ precursors and impaired activated population by Laakso, Sini M, Laurinolli, Tuisku-Tuulia, Rossi, Laura H, Lehtoviita, Anni, Sairanen, Heikki, Perheentupa, Jaakko, Kekäläinen, Eliisa, Arstila, T. Petteri

“…Abstract The pathogenetic mechanisms of organ-specific autoimmune diseases remain obscured by the complexity of the genetic and environmental factors…”
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Expanded CD4+ Effector/Memory T Cell Subset in APECED Produces Predominantly Interferon Gamma by Heikkilä, Nelli, Laakso, Sini M., Mannerström, Helga, Kekäläinen, Eliisa, Saavalainen, Päivi, Jarva, Hanna, Arstila, Tommi P.

“…Purpose Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) is a rare human autoimmune disorder caused by mutations in the AIRE (autoimmune…”
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IL-7 dysregulation and loss of CD8+ T cell homeostasis in the monogenic human disease autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy by Laakso, Sini M, Kekäläinen, Eliisa, Rossi, Laura H, Laurinolli, Tuisku-Tuulia, Mannerström, Helga, Heikkilä, Nelli, Lehtoviita, Anni, Perheentupa, Jaakko, Jarva, Hanna, Arstila, T Petteri

“…Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a monogenic autoimmune disease that is caused by mutations in the AIRE gene. Murine…”
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In vivo analysis of helper T cell responses in patients with autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy provides evidence in support of an IL-22 defect by Laakso, Sini M., Kekäläinen, Eliisa, Heikkilä, Nelli, Mannerström, Helga, Kisand, Kai, Peterson, Pärt, Ranki, Annamari, Arstila, T. Petteri

“…Abstract Autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy (APECED) is caused by mutations in the Autoimmune regulator (AIRE) gene and is…”
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