Search Results - "LaValley, Danielle J"
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Matrix stiffening promotes a tumor vasculature phenotype
Published in Proceedings of the National Academy of Sciences - PNAS (17-01-2017)“…Tumor microvasculature tends to be malformed, more permeable, and more tortuous than vessels in healthy tissue, effects that have been largely attributed to…”
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Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro
Published in PLoS computational biology (01-08-2014)“…In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis…”
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Pumpless, unidirectional microphysiological system for testing metabolism‐dependent chemotherapeutic toxicity
Published in Biotechnology progress (01-03-2021)“…Drug development is often hindered by the failure of preclinical models to accurately assess and predict the efficacy and safety of drug candidates…”
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Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2015)“…Alternative splicing of proteins gives rise to different isoforms that play a crucial role in regulating several cellular processes. Notably, splicing profiles…”
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Clinical doses of radiation reduce collagen matrix stiffness
Published in APL bioengineering (01-09-2018)“…Cells receive mechanical cues from their extracellular matrix (ECM), which direct migration, differentiation, apoptosis, and in some cases, the transition to a…”
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Mechanical Cell-Matrix Feedback Explains Pairwise and Collective Endothelial Cell Behavior In Vitro: e1003774
Published in PLoS computational biology (01-08-2014)“…In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis…”
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Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro
Published 04-07-2014“…PLoS Comput Biol 10(8): e1003774, 2014 In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells…”
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