Search Results - "LaSalle, J M"

Epigenomic Convergence of Neural-Immune Risk Factors in Neurodevelopmental Disorder Cortex by Vogel Ciernia, A, Laufer, B I, Hwang, H, Dunaway, K W, Mordaunt, C E, Coulson, R L, Yasui, D H, LaSalle, J M

“…Abstract Neurodevelopmental disorders (NDDs) affect 7–14% of all children in developed countries and are one of the leading causes of lifelong disability…”
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X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma by Selmi, C., Feghali‐Bostwick, C. A., Lleo, A., Lombardi, S. A., De Santis, M., Cavaciocchi, F., Zammataro, L., Mitchell, M. M., LaSalle, J. M., Medsger Jr, T., Gershwin, M. E.

“…Summary Scleroderma (SSc) is a rare connective tissue disease characterized by fibrosis, microvasculopathy and autoimmune features. The role of genetics is…”
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Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number by Hogart, A, Leung, K N, Wang, N J, Wu, D J, Driscoll, J, Vallero, R O, Schanen, N C, LaSalle, J M

“…Chromosome 15q11-13 contains a cluster of imprinted genes essential for normal mammalian neurodevelopment. Deficiencies in paternal or maternal 15q11-13…”
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Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry by LASALLE, Janine M, GOLDSTINE, Jared, BALMER, Damina, GRECO, Claudia M

“…Rett syndrome (RTT) is an X-linked, dominant neurodevelopmental disorder caused by mutations in MECP2, encoding the methyl-CpG-binding protein 2 (MeCP2). A…”
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Homologous Association of Oppositely Imprinted Chromosomal Domains by LaSalle, Janine M., Lalande, Marc

“…Human chromosome 15q11-q13 encompasses the Prader-Willi syndrome (PWS) and the Angelman syndrome (AS) loci, which are subject to parental imprinting, a process…”
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Early signaling defects in human T cells anergized by T cell presentation of autoantigen by LASALLE, J. M, TOLENTINO, P. J, FREEMAN, G. J, NADLER, L. M, HAFLER, D.A

“…Major histocompatibility complex class II-positive human T cell clones are nontraditional antigen-presenting cells (APCs) that are able to simultaneously…”
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High-resolution analysis of DNA replication domain organization across an R/G-band boundary by Strehl, Sabine, LaSalle, Janine M., Lalande, Marc

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution by LaSalle, Janine M, Lalande, Marc

“…Imprinting marks the parental origin of chromosomes, resulting in allele-specific changes in chromatin organization, transcription and replication. We report a…”
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Clonal maintenance of imprinted expression of SNRPN and IPW in normal lymphocytes: correlation with allele-specific methylation of SNRPN intron 1 but not intron 7 by BALMER, Damina, LASALLE, Janine M

“…DNA methylation is a heritable and reversible modification to CpG sites in the mammalian genome. Parental allele-specific methylation is hypothesized to be…”
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Presentation of autoantigen by human T cells by LaSalle, JM, Ota, K, Hafler, DA

“…Activated human T cells express MHC class II and have been shown to present foreign Ag to autologous T cells. We now demonstrate that MHC class II+ T cell…”
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T cell anergy by LaSalle, J M, Hafler, D A

“…T cell clonal anergy is a proposed mechanism of immunologic self tolerance in which T cells become functionally inactivated after previous stimulation. MHC…”
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T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen by LaSalle, JM, Toneguzzo, F, Saadeh, M, Golan, DE, Taber, R, Hafler, DA

“…MHC class II+ human T-cell clones are able to simultaneously present and respond to peptide Ag and superantigen resulting in both proliferation and subsequent…”
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RAB22 and RAB163/Mouse BRCA2: Proteins that Specifically Interact with the RAD51 Protein by Mizuta, Ryushin, LaSalle, Janine M., Cheng, Hwei-Ling, Shinohara, Akira, Ogawa, Hideyuki, Copeland, Neal, Jenkins, Nancy A., Lalande, Marc, Alt, Frederick W.

“…The human RAD51 protein is a homologue of the bacteria RecA and yeast RAD51 proteins that are involved in homologous recombination and DNA repair. RAD51…”
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Biological activity of recombinant human myelin basic protein by Oettinger, H F, al-Sabbagh, A, Jingwu, Z, LaSalle, J M, Weiner, H L, Hafler, D A

“…Using an inducible expression vector in Escherichia coli, we have expressed, purified, and biologically characterized recombinant human myelin basic protein…”
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Detection of low level HER-2/neu gene amplification in prostate cancer by fluorescence in situ hybridization by Liu, H L, Gandour-Edwards, R, Lara, Jr, P N, de Vere White, R, LaSalle, J M

“…Although expression of the HER-2/neu oncogene has been correlated with tumor progression in prostate cancer, the biologic significance of detecting HER-2/neu…”
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Evolving role of MeCP2 in Rett syndrome and autism by LaSalle, Janine M, Yasui, Dag H

“…Rett syndrome is an X-linked autism-spectrum disorder caused by mutations in MECP2, encoding methyl CpG-binding protein 2. Since the discovery of MECP2…”
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Clonal Heterogeneity at Allelic Methylation Sites Diagnostic for Prader-Willi and Angelman Syndromes by LaSalle, Janine M., Ritchie, Rachael J., Glatt, Heather, Lalande, Marc

“…Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are developmental disorders resulting from the absence of the paternal or maternal contribution to the…”
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The Entropy and Structure of the Pervanadyl Ion by LaSalle, M. J, Cobble, James W

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Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome by Yasui, D. H., Gonzales, M. L., Aflatooni, J. O., Crary, F. K., Hu, D. J., Gavino, B. J., Golub, M. S., Vincent, J. B., Schanen, N. C., Olson, C. O., Rastegar, M., Lasalle, J. M.

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Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3 by Samaco, Rodney C., Hogart, Amber, LaSalle, Janine M.

“…Autism is a common neurodevelopmental disorder of complex genetic etiology. Rett syndrome, an X-linked dominant disorder caused by MECP2 mutations, and…”
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