Search Results - "LaRue, Amanda"

Effects of Neurological Disorders on Bone Health by Kelly, Ryan R, Sidles, Sara J, LaRue, Amanda C

“…Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis…”
Get full text

Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis by McDonald, Lindsay T, Zile, Michael R, Zhang, Yuhua, Van Laer, An O, Baicu, Catalin F, Stroud, Robert E, Jones, Jeffrey A, LaRue, Amanda C, Bradshaw, Amy D

“…Myocardial fibrosis and the resultant increases in left ventricular stiffness represent pivotal consequences of chronic pressure overload (PO) that impact both…”
Get more information

Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions by Kelly, Ryan R, McDonald, Lindsay T, Jensen, Nathaniel R, Sidles, Sara J, LaRue, Amanda C

“…The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including…”
Get full text

Inescapable foot shock induces a PTSD-like phenotype and negatively impacts adult murine bone by Sidles, Sara J, Kelly, Ryan R, Kelly, Kirsten D, Hathaway-Schrader, Jessica D, Khoo, Stephanie K, Jones, Jeffrey A, Cray, James J, LaRue, Amanda C

“…Post-traumatic stress disorder (PTSD) is associated with osteopenia, osteoporosis and increased fracture risk in the clinical population. Yet, the development…”
Get full text

Total body irradiation selectively induces murine hematopoietic stem cell senescence by Wang, Yong, Schulte, Bradley A., LaRue, Amanda C., Ogawa, Makio, Zhou, Daohong

“…Exposure to ionizing radiation (IR) and certain chemotherapeutic agents not only causes acute bone marrow (BM) suppression but also leads to long-term residual…”
Get full text

Hematopoietic stem cell‐derived functional osteoblasts exhibit therapeutic efficacy in a murine model of osteogenesis imperfecta by Kang, In‐Hong, Baliga, Uday K., Wu, Yongren, Mehrotra, Shikhar, Yao, Hai, LaRue, Amanda C., Mehrotra, Meenal

“…Currently, there is no cure for osteogenesis imperfecta (OI)—a debilitating pediatric skeletal dysplasia. Herein we show that hematopoietic stem cell (HSC)…”
Get full text

Hematopoietic stem cells are pluripotent and not just “hematopoietic” by Ogawa, Makio, LaRue, Amanda C., Mehrotra, Meenal

“…Over a decade ago, several preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability (often referred to as HSC…”
Get full text

Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis by McDonald, Lindsay T, Johnson, Sara D, Russell, Dayvia L, Young, M Rita I, LaRue, Amanda C

“…Micro-injuries associated with chronic inhaled particle exposures are linked with activation of the immune response and are thought to contribute to…”
Get full text

In utero exposure to selective serotonin re‐uptake inhibitor affects murine mandibular development by Boyce, Mark A., Durham, Emily L., Kuo, Sharon, Taylor, Jane M., Kishinchand, Rajiv, LaRue, Amanda C., Cray, James J.

“…Objectives Antidepressants, specifically Selective Serotonin Re‐uptake Inhibitors (SSRIs), that alter serotonin metabolism are currently the most commonly…”
Get full text

From Stem to Sternum: The Role of Shp2 in the Skeleton by Jensen, Nathaniel R., Kelly, Ryan R., Kelly, Kirsten D., Khoo, Stephanie K., Sidles, Sara J., LaRue, Amanda C.

“…Src homology-2 domain-containing phosphatase 2 (SHP2) is a ubiquitously expressed phosphatase that is vital for skeletal development and maintenance of…”
Get full text

HDAC inhibition helps post-MI healing by modulating macrophage polarization by Kimbrough, Denise, Wang, Sabina H., Wright, Lillianne H., Mani, Santhosh K., Kasiganesan, Harinath, LaRue, Amanda C., Cheng, Qi, Nadig, Satish N., Atkinson, Carl, Menick, Donald R.

“…Following an acute myocardial infarction (MI) the extracellular matrix (ECM) undergoes remodeling in order to prevent dilation of the infarct area and maintain…”
Get full text

SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload by Riley, Hannah J, Kelly, Ryan R, Van Laer, An O, Neff, Lily S, Dasgupta, Shaoni, Baicu, Catalin F, McDonald, Lindsay T, LaRue, Amanda C, Zile, Michael R, Bradshaw, Amy D

“…In human heart failure and in murine hearts with left-ventricular pressure overload (LVPO), increases in fibrosis are associated with increases in myocardial…”
Get more information

Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors by An, Ningfei, Xiong, Ying, LaRue, Amanda C, Kraft, Andrew S, Cen, Bo

“…Mesenchymal-epithelial transition (MET) blockade offers a new targeted therapy particularly in those cancers with MET amplification. However, the efficacy and…”
Get full text

Optimizing bone wound healing using BMP2 with absorbable collagen sponge and Talymed nanofiber scaffold by Durham, Emily L, Howie, R Nicole, Hall, SarahRose, Larson, Nicholas, Oakes, Brayden, Houck, Reed, Grey, Zachary, Steed, Martin, LaRue, Amanda C, Muise-Helmericks, Robin, Cray, James

“…Bone is a highly vascularized and resilient organ with innate healing abilities, however some bone injuries overwhelm these attributes and require…”
Get full text

FLI1 in PBMCs contributes to elevated inflammation in combat-related posttraumatic stress disorder by Li, Pengfei, Liu, Liu, Liu, Shufeng, Lu, Zhongyang, Halushka, Perry V, Sidles, Sara J, LaRue, Amanda C, Wang, Zhewu, Fan, Hongkuan

“…Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition with significant public health implications that arise following exposure to…”
Get full text

Hematopoietic origin of fibroblasts/myofibroblasts: its pathophysiologic implications by Ogawa, Makio, LaRue, Amanda C., Drake, Christopher J.

“…Tissue fibroblasts/myofibroblasts play a key role in growth factor secretion, matrix deposition, and matrix degradation, and therefore are important in many…”
Get full text

The Pim-1 Protein Kinase Is an Important Regulator of MET Receptor Tyrosine Kinase Levels and Signaling by Cen, Bo, Xiong, Ying, Song, Jin H., Mahajan, Sandeep, DuPont, Rachel, McEachern, Kristen, DeAngelo, Daniel J., Cortes, Jorge E., Minden, Mark D., Ebens, Allen, Mims, Alice, LaRue, Amanda C., Kraft, Andrew S.

“…MET, the receptor for hepatocyte growth factor (HGF), plays an important role in signaling normal and tumor cell migration and invasion. Here, we describe a…”
Get full text

Pressure overload generates a cardiac-specific profile of inflammatory mediators by O'Brien, Matthew, Baicu, Catalin F, Van Laer, An O, Zhang, Yuhua, McDonald, Lindsey T, LaRue, Amanda C, Zile, Michael R, Bradshaw, Amy D

“…Mechanisms that contribute to myocardial fibrosis, particularly in response to left ventricular pressure overload (LVPO), remain poorly defined. To test the…”
Get more information

Plasticity of hematopoietic stem cells by Ogawa, Makio, LaRue, Amanda C, Mehrotra, Meenal

“…Abstract Almost two decades ago, a number of cell culture and preclinical transplantation studies suggested the striking concept of the tissue-reconstituting…”
Get full text

Understanding the Role of ETS-Mediated Gene Regulation in Complex Biological Processes by Findlay, Victoria J., LaRue, Amanda C., Turner, David P., Watson, Patricia M., Watson, Dennis K.

“…Ets factors are members of one of the largest families of evolutionarily conserved transcription factors, regulating critical functions in normal cell…”
Get full text