Search Results - "LaRosa, Gregory"

Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice by van Maanen, Marjolein A, Papke, Roger L, Koopman, Frieda A, Koepke, Jessica, Bevaart, Lisette, Clark, Roger, Lamppu, Diana, Elbaum, Daniel, LaRosa, Gregory J, Tak, Paul P, Vervoordeldonk, Margriet J

“…The cholinergic anti-inflammatory pathway can downregulate inflammation via the release of acetylcholine (ACh) by the vagus nerve. This neurotransmitter binds…”
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The Vagus Nerve and Nicotinic Receptors Modulate Experimental Pancreatitis Severity in Mice by van Westerloo, David J., Giebelen, Ilona A., Florquin, Sandrine, Bruno, Marco J., LaRosa, Gregory J., Ulloa, Luis, Tracey, Kevin J., van der Poll, T.

“…Background & Aims: The nervous system, through the vagus nerve, controls inflammation by decreasing the release of tumor necrosis factor-α from endotoxin…”
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Selective α7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis by Pavlov, Valentin A, Ochani, Mahendar, Yang, Li-Hong, Gallowitsch-Puerta, Margot, Ochani, Kanta, Lin, Xinchun, Levi, Jelena, Parrish, William R, Rosas-Ballina, Mauricio, Czura, Christopher J, LaRosa, Gregory J, Miller, Edmund J, Tracey, Kevin J, Al-Abed, Yousef

“…OBJECTIVE:Tumor necrosis factor and high mobility group box 1 are critical cytokine mediators of inflammation. The efferent vagus nerve inhibits cytokine…”
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Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor α7 subunit gene knockout mice by van Maanen, Marjolein A, Stoof, Susanne P, Larosa, Gregory J, Vervoordeldonk, Margriet J, Tak, Paul P

“…The alpha7 subunit of nicotinic acetylcholine receptors (alpha7nAChR) can negatively regulate the synthesis and release of proinflammatory cytokines by…”
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Activation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Postoperative Ileus in Mice by The, Frans O, Boeckxstaens, Guy E, Snoek, Susanne A, Cash, Jenna L, Bennink, Roel, LaRosa, Gregory J, van den Wijngaard, Rene M, Greaves, David R, de Jonge, Wouter J

“…Background & Aims: We previously showed that intestinal inflammation is reduced by electrical stimulation of the efferent vagus nerve, which prevents…”
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In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels by Cherry, Jonathan J, DiDonato, Christine J, Androphy, Elliot J, Calo, Alessandro, Potter, Kyle, Custer, Sara K, Du, Sarah, Foley, Timothy L, Gopalsamy, Ariamala, Reedich, Emily J, Gordo, Susana M, Gordon, William, Hosea, Natalie, Jones, Lyn H, Krizay, Daniel K, LaRosa, Gregory, Li, Hongxia, Mathur, Sachin, Menard, Carol A, Patel, Paraj, Ramos-Zayas, Rebeca, Rietz, Anne, Rong, Haojing, Zhang, Baohong, Tones, Michael A

“…C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS (DAQ-DcpSi) have been developed for the treatment of spinal muscular…”
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A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b by Zhou, Hua, Olsen, Henrik, So, Edward, Mérigeon, Emmanuel, Rybin, Denis, Owens, Jane, LaRosa, Gregory, Block, David S., Strome, Scott E., Zhang, Xiaoyu

“…GL-2045 is a recombinant human immunoglobulin G1 (IgG1)–based Fc multimer designed to recapitulate the anti-inflammatory activities of intravenous…”
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Stimulation of alpha 7 cholinergic receptors inhibits lipopolysaccharide-induced neutrophil recruitment by a tumor necrosis factor alpha-independent mechanism by Giebelen, Ida A J, van Westerloo, David J, LaRosa, Gregory J, de Vos, Alex F, van der Poll, Tom

“…The cholinergic nervous system controls inflammation by inhibiting the release of proinflammatory cytokines such as tumor necrosis factor (TNF) alpha from…”
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HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay by Wähämaa, Heidi, Vallerskog, Therese, Qin, Shixin, Lunderius, Carolina, LaRosa, Gregory, Andersson, Ulf, Harris, Helena Erlandsson

“…High mobility group box protein 1 (HMGB1) exerts different biological functions dependent on its cellular localization. Nuclear HMGB1 maintains chromatin…”
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Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo by van Zoelen, Marieke A D, de Vos, Alex F, Larosa, Gregory J, Draing, Christian, von Aulock, Sonja, van der Poll, Tom

“…Ethyl pyruvate (EP) is a stable pyruvate derivative that has been shown to exert anti-inflammatory effects in various models of systemic inflammation including…”
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The Second Extracellular Loop of CCR5 Is the Major Determinant of Ligand Specificity by Samson, Michel, LaRosa, Gregory, Libert, Frédérick, Paindavoine, Pascale, Detheux, Michel, Vassart, Gilbert, Parmentier, Marc

“…The chemokine receptor CCR5 binds macrophage inflammatory protein (MIP)-1α, MIP-1β, and regulated on activation, normal T-cell expressed and secreted (RANTES),…”
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G Protein-Coupled Signal Transduction Pathways for Interleukin-8 by Wu, Dianqing, LaRosa, Gregory J., Simon, Melvin I.

“…Interleukin-8 (IL-8) is one of the major mediators of the inflammatory response. The pathways by which IL-8 activates inositide-specific phospholipase C (PLC)…”
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Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium by KUMAR, A. G, BALLANTYNE, C. M, ROSSEN, R. D, SMITH, C. W, ENTMAN, M. L, MICHAEL, L. H, KUKIELKA, G. L, YOUKER, K. A, LINDSEY, M. L, HAWKINS, H. K, BIRDSALL, H. H, MACKAY, C. R, LAROSA, G. J

“…Healing after myocardial infarction is characterized by the presence of macrophages in the infarcted area. Since augmented monocyte influx has been implicated…”
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Basophil Responses to Chemokines Are Regulated by Both Sequential and Cooperative Receptor Signaling by Heinemann, Akos, Hartnell, Adele, Stubbs, Victoria E. L, Murakami, Kazuki, Soler, Dulce, LaRosa, Gregory, Askenase, Philip W, Williams, Timothy J, Sabroe, Ian

“…To investigate human basophil responses to chemokines, we have developed a sensitive assay that uses flow cytometry to measure leukocyte shape change as a…”
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Stimulation of nicotinic acetylcholine receptors attenuates collagen‐induced arthritis in mice by van Maanen, Marjolein A., Lebre, Maria C., van der Poll, Tom, LaRosa, Gregory J., Elbaum, Daniel, Vervoordeldonk, Margriet J., Tak, Paul P.

“…Objective The parasympathetic nervous system, through the vagus nerve, can down‐regulate inflammation in vivo by decreasing the release of cytokines, including…”
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Functional Differences Between Monocyte Chemotactic Protein-1 Receptor A and Monocyte Chemotactic Protein-1 Receptor B Expressed in a Jurkat T Cell by Sanders, Sheila K, Crean, Sheila M, Boxer, Peter A, Kellner, Debra, LaRosa, Gregory J, Hunt, Stephen W., III

“…The monocyte chemotactic protein-1 (MCP-1) receptor (MCP-1R) is expressed on monocytes, a subpopulation of memory T lymphocytes, and basophils. Two…”
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Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant by LaRosa, Gregory J., Davide, Joseph P., Weinhold, Kent, Waterbury, Julie A., Profy, Albert T., Lewis, John A., Langlois, Alphonse J., Dreesman, Gordon R., Boswell, R. Neal, Shadduck, Phillip, Holley, L. Howard, Karplus, Martin, Bolognesi, Dani P., Matthews, Thomas J., Emini, Emilio A., Putney, Scott D.

“…The principal neutralizing determinant (PND) of human immunodeficiency virus HIV-1 is part of a disulfide bridged loop in the third variable region of the…”
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Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest by Faria, Teresa N, LaRosa, Gregory J, Wilen, Elana, Liao, Jack, Gudas, Lorraine J

“…In the presence of retinoic acid (RA), F9 murine teratocarcinoma cells differentiate into cells resembling the extra-embryonic endoderm of the early mouse…”
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Up-Regulation of CCR2 Chemokine Receptor Expression and Increased Susceptibility to the Multitropic HIV Strain 89.6 in Monocytes Exposed to Glucocorticoid Hormones by Penton-Rol, Giselle, Cota, Manuela, Polentarutti, Nadia, Luini, Walter, Bernasconi, Sergio, Borsatti, Alessandro, Sica, Antonio, LaRosa, Gregory J, Sozzani, Silvano, Poli, Guido, Mantovani, Alberto

“…Glucocorticoid hormones (GC) are potent antiinflammatory agents widely used in the treatment of diverse human diseases. The present study was aimed at…”
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CCR2-64I Polymorphism Is Not Associated with Altered CCR5 Expression or Coreceptor Function by Mariani, R, Wong, S, Mulder, L C, Wilkinson, D A, Reinhart, A L, LaRosa, G, Nibbs, R, O'Brien, T R, Michael, N L, Connor, R I, Macdonald, M, Busch, M, Koup, R A, Landau, N R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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