Search Results - "LaPointe, Lawrence"

A two-gene blood test for methylated DNA sensitive for colorectal cancer by Pedersen, Susanne K, Baker, Rohan T, McEvoy, Aidan, Murray, David H, Thomas, Melissa, Molloy, Peter L, Mitchell, Sue, Lockett, Trevor, Young, Graeme P, LaPointe, Lawrence C

“…Specific genes are methylated with high frequency in colorectal neoplasia, and may leak into blood. Detection of multiple methylated DNA biomarkers in blood…”
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A panel of genes methylated with high frequency in colorectal cancer by Mitchell, Susan M, Ross, Jason P, Drew, Horace R, Ho, Thu, Brown, Glenn S, Saunders, Neil F W, Duesing, Konsta R, Buckley, Michael J, Dunne, Rob, Beetson, Iain, Rand, Keith N, McEvoy, Aidan, Thomas, Melissa L, Baker, Rohan T, Wattchow, David A, Young, Graeme P, Lockett, Trevor J, Pedersen, Susanne K, Lapointe, Lawrence C, Molloy, Peter L

“…The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene…”
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Detection of recurrent colorectal cancer with high specificity using a reporting threshold for circulating tumor DNA methylated in BCAT1 and IKZF1 by Pedersen, Susanne K., Musher, Benjamin L., LaPointe, Lawrence C., Tuck, Melissa K., Symonds, Erin L., Loayza, Naima, Young, Graeme P.

“…Background A blood assay measuring methylated BCAT1 and IKZF1 can detect recurrent colorectal cancer (CRC) with high sensitivity but suboptimal specificity…”
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Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1 to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC) by Musher, Benjamin L, Melson, Joshua E, Amato, Gianni, Chan, David, Hill, Marisa, Khan, Iftekhar, Kochuparambil, Samith T, Lyons, Susan E, Orsini, Jr, James, Pedersen, Susanne K, Robb, Bruce, Saltzman, Joel, Silinsky, Jennifer, Gaur, Snigdha, Tuck, Melissa K, LaPointe, Lawrence C, Young, Graeme P

“…Most recurrences of early-stage colorectal cancer detected with current surveillance measures are widespread and incurable. Circulating tumor DNA (ctDNA) may…”
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Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia by Pedersen, Susanne K, Symonds, Erin L, Baker, Rohan T, Murray, David H, McEvoy, Aidan, Van Doorn, Sascha C, Mundt, Marco W, Cole, Stephen R, Gopalsamy, Geetha, Mangira, Dileep, LaPointe, Lawrence C, Dekker, Evelien, Young, Graeme P

“…Specific genes, such as BCAT1 and IKZF1, are methylated with high frequency in colorectal cancer (CRC) tissue compared to normal colon tissue specimens. Such…”
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Evaluation of Methylation Biomarkers for Detection of Circulating Tumor DNA and Application to Colorectal Cancer by Mitchell, Susan M, Ho, Thu, Brown, Glenn S, Baker, Rohan T, Thomas, Melissa L, McEvoy, Aidan, Xu, Zheng-Zhou, Ross, Jason P, Lockett, Trevor J, Young, Graeme P, LaPointe, Lawrence C, Pedersen, Susanne K, Molloy, Peter L

“…Solid tumors shed DNA into circulation, and there is growing evidence that the detection of circulating tumor DNA (ctDNA) has broad clinical utility, including…”
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Detection of methylated BCAT1 and IKZF1 after curative‐intent treatment as a prognostic indicator for colorectal cancer recurrence by Pedersen, Susanne K., Symonds, Erin L., Roy, Amitesh C., Cornthwaite, Kathryn J., LaPointe, Lawrence C., Young, Graeme P.

“…Background The risk of recurrence after completion of curative‐intent treatment of colorectal cancer (CRC) is hard to predict. Post‐treatment assaying for…”
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Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testing by LaPointe, Lawrence C, Pedersen, Susanne K, Dunne, Robert, Brown, Glenn S, Pimlott, Letitia, Gaur, Snigdha, McEvoy, Aidan, Thomas, Melissa, Wattchow, David, Molloy, Peter L, Young, Graeme P

“…Colorectal cancer incidence and deaths are reduced by the detection and removal of early-stage, treatable neoplasia but we lack proven biomarkers sensitive for…”
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A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia by Symonds, Erin L, Pedersen, Susanne K, Baker, Rohan T, Murray, David H, Gaur, Snigdha, Cole, Stephen R, Gopalsamy, Geetha, Mangira, Dileep, LaPointe, Lawrence C, Young, Graeme P

“…To compare the performance of a new blood test for colorectal cancer (CRC) to an established fecal immunochemical test (FIT) in a study population with the…”
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Colorectal Neoplasia Differentially Expressed (CRNDE), a Novel Gene with Elevated Expression in Colorectal Adenomas and Adenocarcinomas by Graham, Lloyd D, Pedersen, Susanne K, Brown, Glenn S, Ho, Thu, Kassir, Zena, Moynihan, Audrey T, Vizgoft, Emma K, Dunne, Robert, Pimlott, Letitia, Young, Graeme P, Lapointe, Lawrence C, Molloy, Peter L

“…An uncharacterized gene locus (Chr16:hCG_1815491), now named colorectal neoplasia differentially expressed (gene symbol CRNDE), is activated early in…”
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Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer by Young, Graeme P, Symonds, Erin L, Nielsen, Hans Jørgen, Ferm, Linnea, Christensen, Ib J, Dekker, Evelien, van der Vlugt, Manon, Mallant-Hent, Rosalie C, Boulter, Nicky, Yu, Betty, Chan, Michelle, Tevz, Gregor, LaPointe, Lawrence C, Pedersen, Susanne K

“…Differentially-methylated regions (DMRs) are characteristic of colorectal cancer (CRC) and some occur more frequently than common mutations. This study aimed…”
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Map of differential transcript expression in the normal human large intestine by LaPointe, Lawrence C, Dunne, Robert, Brown, Glenn S, Worthley, Daniel L, Molloy, Peter L, Wattchow, David, Young, Graeme P

“…1 Department of Medicine, Flinders University of South Australia, Adelaide, South Australia 2 Preventative Health National Research Flagship, CSIRO…”
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Mo1947 Detection of Variable Methylation Patterns Improves Sensitivity of a Colorectal Cancer Blood Test by Baker, Rohan T, Gaur, Snigdha, Murray, David, McEvoy, Aidan, Young, Graeme P, LaPointe, Lawrence C, Redersen, Susanne K

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Sa1949 Methylated BCAT1 and IKZF1 DNA in Plasma As Novel Biomarkers for Colorectal Cancer Recurrence by Symonds, Erin L, Mansfield, Scott, Mangira, Dileep, Murray, David, Baker, Rohan T, Pedersen, Susanne K, LaPointe, Lawrence C, Young, Graeme P

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Sa1941 The Morphological Features of Colorectal Tumors That Are Associated With the Appearance of Methylated DNA in Plasma by Mangira, Dileep, Symonds, Erin L, Young, Graeme P, Cole, Stephen R, Bambacas, Libby, Murray, David, Baker, Rohan T, LaPointe, Lawrence C, Pedersen, Susanne K

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Mo1928 Improving Participation Rates in Community-Based Colorectal Cancer Screening - Role of a Blood Test As a Novel Biomarker by Symonds, Erin L, Pedersen, Susanne K, Cole, Stephen R, Murray, David, Massolino, Joe, Byrne, Daniel T, Guy, John Guy R., Dr, Backhouse, Patricia, Fraser, Robert J, LaPointe, Lawrence C, Young, Graeme P

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Mo1943 Comparison of a Methylated Two-Gene ( BCAT1-IKZF1 ) Blood Test to FIT for Detection of Colorectal Neoplasia by Symonds, Erin L, Young, Graeme P, Osborne, Joanne M, Cole, Stephen R, Gopalsamy, Geetha, Gaur, Snigdha, Murray, David, Baker, Rohan T, LaPointe, Lawrence C, Pedersen, Susanne K

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228 Evaluation of a 2-Gene ( IKZF1 and BCAT1 ) DNA Blood Test for Detection of Colorectal Cancer by Young, Graeme P, Pedersen, Susanne K, Dekker, Evelien, Cole, Stephen R, Osborne, Joanne M, Symonds, Erin L, Mallant-Hent, Rosalie C, McEvoy, Aidan, Baker, Rohan, Gaur, Snigdha, Murray, David H, LaPointe, Lawrence C

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228 Evaluation of a 2-Gene ( IKZF1 and BCAT1 ) DNA Blood Test for Detection of Colorectal Cancer by Young, Graeme P, Pedersen, Susanne K, Dekker, Evelien, Cole, Stephen R, Osborne, Joanne M, Symonds, Erin L, Mallant-Hent, Rosalie C, Mcevoy, Aidan, Baker, Rohan, Gaur, Snigdha, Murray, David H, Lapointe, Lawrence C

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Plasma Testing of Gene Expression Biomarkers for Colorectal Neoplasia Discovered in Neoplastic Colorectal Tissue by Thomas, Melissa L, Pedersen, Susanne K, McEvoy, Aidan, Vizgoft, Emma, Gaur, Snigdha, Beeston, Iain, LaPointe, Lawrence C

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