Search Results - "LaPlante, Emily"

Deconvolution of cancer cell states by the XDec-SM method by Murillo, Oscar D, Petrosyan, Varduhi, LaPlante, Emily L, Dobrolecki, Lacey E, Lewis, Michael T, Milosavljevic, Aleksandar

“…Proper characterization of cancer cell states within the tumor microenvironment is a key to accurately identifying matching experimental models and the…”
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Testicular germ cell tumors arise in the absence of sex-specific differentiation by Webster, Nicholas J, Maywald, Rebecca L, Benton, Susan M, Dawson, Emily P, Murillo, Oscar D, LaPlante, Emily L, Milosavljevic, Aleksandar, Lanza, Denise G, Heaney, Jason D

“…In response to signals from the embryonic testis, the germ cell intrinsic factor NANOS2 coordinates a transcriptional program necessary for the differentiation…”
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XDec-CHI reveals immunosuppressive interactions in pancreatic ductal adenocarcinoma by LaPlante, Emily L., Liu, Dongliang, Petrosyan, Varduhi, Yao, Qizhi, Milosavljevic, Aleksandar

“…Most cancers harbor a diverse collection of cell types including a typically heterogeneous cancer cell fraction. To reconstruct cell-intrinsic and heterotypic…”
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Histoepigenetic analysis of the mesothelin network within pancreatic ductal adenocarcinoma cells reveals regulation of retinoic acid receptor gamma and AKT by mesothelin by Lurie, Eugene, Liu, Dongliang, LaPlante, Emily L., Thistlethwaite, Lillian R., Yao, Qizhi, Milosavljevic, Aleksandar

“…To enable computational analysis of regulatory networks within the cancer cell in its natural tumor microenvironment, we develop a two-stage histoepigenetic…”
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Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts by Petrosyan, Varduhi, Dobrolecki, Lacey E., LaPlante, Emily L., Srinivasan, Ramakrishnan Rajaram, Bailey, Matthew H., Welm, Alana L., Welm, Bryan E., Lewis, Michael T., Milosavljevic, Aleksandar

“…TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward…”
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Open Problems in Extracellular RNA Data Analysis: Insights From an ERCC Online Workshop by Alexander, Roger P, Kitchen, Robert R, Tosar, Juan Pablo, Roth, Matthew, Mestdagh, Pieter, Max, Klaas E A, Rozowsky, Joel, Kaczor-Urbanowicz, Karolina Elżbieta, Chang, Justin, Balaj, Leonora, Losic, Bojan, Van Nostrand, Eric L, LaPlante, Emily, Mateescu, Bogdan, White, Brian S, Yu, Rongshan, Milosavljevic, Aleksander, Stolovitzky, Gustavo, Spengler, Ryan M

“…We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These…”
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exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers by LaPlante, Emily L., Stürchler, Alessandra, Fullem, Robert, Chen, David, Starner, Anne C., Esquivel, Emmanuel, Alsop, Eric, Jackson, Andrew R., Ghiran, Ionita, Pereira, Getulio, Rozowsky, Joel, Chang, Justin, Gerstein, Mark B., Alexander, Roger P., Roth, Matthew E., Franklin, Jeffrey L., Coffey, Robert J., Raffai, Robert L., Mansuy, Isabelle M., Stavrakis, Stavros, deMello, Andrew J., Laurent, Louise C., Wang, Yi-Ting, Tsai, Chia-Feng, Liu, Tao, Jones, Jennifer, Van Keuren-Jensen, Kendall, Van Nostrand, Eric, Mateescu, Bogdan, Milosavljevic, Aleksandar

“…Although the role of RNA binding proteins (RBPs) in extracellular RNA (exRNA) biology is well established, their exRNA cargo and distribution across biofluids…”
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Abstract PO-004: Basal-like, Classical A, and Classical B subtypes of pancreatic cancer show distinct immuno-suppressive molecular profiles by LaPlante, Emily L., Liu, Dongliang, Milosavljevic, Aleksandar, Yao, Qizhi

“…Abstract With recent advances in distinguishing Pancreatic Ductal Adenocarcinoma (PDAC) subtypes based on transcriptional profiles, it is becoming clear that…”
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Abstract PO-115: Effects of mesothelin exert on tumor microenvironment in pancreatic ductal adenocarcinoma by Liu, Dongliang, Poteet, Ethan, Liang, Zhengdong, Laplante, Emily, Brubaker, Lisa, Dhingra, Sadhna, Milosavljevic, Aleksandar, Chen, Changyi, Yao, Qizhi Cathy

“…Abstract Background: High mesothelin (MSLN) expression has been associated with poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC);…”
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Abstract 7420: Optimizing proteomic data access and analysis in the cloud: Leveraging Terra's integration with the Proteomic Data Commons by LaPlante, Emily, Huo, Bingxing, Mani, DR, Thangudu, Ratna R.

“…Abstract The Proteomic Data Commons (PDC) hosts cancer proteomics data with the goal of making this data available to the public to support development of…”
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Abstract 2079: Tumor-derived fibrinogen promotes pancreatic ductal adenocarcinoma progression by Liu, Dongliang, Brubaker, Lisa, Niu, Yichi, LaPlante, Emily, Van Buren, George, Milosavljevic, Aleksandar, Chen, Changyi, Zong, Chenghang, Cruz, Miguel, Yao, Qizhi

“…Abstract Background: Hypercoagulability is a common clinical manifestation in patients with cancers, especially in pancreatic ductal adenocarcinoma (PDAC)…”
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