Search Results - "LaPerle, Jennifer"

A comprehensive non‐clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder by Callegari, Ernesto, Malhotra, Bimal, Bungay, Peter J., Webster, Rob, Fenner, Katherine S., Kempshall, Sarah, LaPerle, Jennifer L., Michel, Martin C., Kay, Gary G.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • This study provides antimuscarinic agents for overactive bladder (OAB) display variable association with side…”
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THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL by Doran, Angela, Obach, R Scott, Smith, Bill J, Hosea, Natilie A, Becker, Stacey, Callegari, Ernesto, Chen, Cuiping, Chen, Xi, Choo, Edna, Cianfrogna, Julie, Cox, Loretta M, Gibbs, John P, Gibbs, Megan A, Hatch, Heather, Hop, Cornelis E C A, Kasman, Ilana N, Laperle, Jennifer, Liu, Jianhua, Liu, Xingrong, Logman, Michael, Maclin, Debra, Nedza, Frank M, Nelson, Frederick, Olson, Emily, Rahematpura, Sandhya, Raunig, David, Rogers, Sabrinia, Schmidt, Kari, Spracklin, Douglas K, Szewc, Mark, Troutman, Matthew, Tseng, Elaine, Tu, Meihua, Van Deusen, Jeffrey W, Venkatakrishnan, Karthik, Walens, Gary, Wang, Ellen Q, Wong, Diane, Yasgar, Adam S, Zhang, Chenghong

“…Thirty-two structurally diverse drugs used for the treatment of various conditions of the central nervous system (CNS), along with two active metabolites, and…”
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Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor by Dow, Robert L., Andrews, Melissa P., Li, Jian-Cheng, Michael Gibbs, E., Guzman-Perez, Angel, LaPerle, Jennifer L., Li, Qifang, Mather, Dawn, Munchhof, Michael J., Niosi, Mark, Patel, Leena, Perreault, Christian, Tapley, Susan, Zavadoski, William J.

“…DGAT-1 is an enzyme that catalyzes the final step in triglyceride synthesis. mRNA knockout experiments in rodent models suggest that inhibitors of this enzyme…”
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Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans by Maciejewski, Benjamin S, LaPerle, Jennifer L, Chen, Danny, Ghosh, Avijit, Zavadoski, William J, McDonald, Thomas S, Manion, Tara B, Mather, Dawn, Patterson, Terrell A, Hanna, Maya, Watkins, Steven, Gibbs, E Michael, Calle, Roberto A, Steppan, Claire M

“…Alterations in fat metabolism, in particular elevated plasma concentrations of free fatty acids and triglycerides (TG), have been implicated in the…”
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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1 by Dow, Robert L, Li, Jian-Cheng, Pence, Michael P, Gibbs, E. Michael, LaPerle, Jennifer L, Litchfield, John, Piotrowski, David W, Munchhof, Michael J, Manion, Tara B, Zavadoski, William J, Walker, Gregory S, McPherson, R. Kirk, Tapley, Susan, Sugarman, Eliot, Guzman-Perez, Angel, DaSilva-Jardine, Paul

“…Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides. DGAT-1 knockout mice have been…”
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Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3- d]pyrimidine core by Dow, Robert L., Andrews, Melissa, Aspnes, Gary E., Balan, Gayatri, Michael Gibbs, E., Guzman-Perez, Angel, Karki, Kapil, LaPerle, Jennifer L., Li, Jian-Cheng, Litchfield, John, Munchhof, Michael J., Perreault, Christian, Patel, Leena

“…A novel series of potent DGAT-1 inhibitors was developed originating from the lactam-based clinical candidate PF-04620110. Incorporation of a dioxino[2,3-…”
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Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment by Ammirati, Mark, Bagley, Scott W, Bhattacharya, Samit K, Buckbinder, Leonard, Carlo, Anthony A, Conrad, Rebecca, Cortes, Christian, Dow, Robert L, Dowling, Matthew S, El-Kattan, Ayman, Ford, Kristen, Guimarães, Cristiano R. W, Hepworth, David, Jiao, Wenhua, LaPerle, Jennifer, Liu, Shenping, Londregan, Allyn, Loria, Paula M, Mathiowetz, Alan M, Munchhof, Michael, Orr, Suvi T. M, Petersen, Donna N, Price, David A, Skoura, Athanasia, Smith, Aaron C, Wang, Jian

“…Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for…”
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Corrigendum to “Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor” [Bioorg. Med. Chem. 21 (2013) 5081–5097] by Dow, Robert L., Andrews, Melissa P., Li, Jian-Cheng, Michael Gibbs, E., Guzman-Perez, Angel, LaPerle, Jennifer L., Li, Qifang, Mather, Dawn, Munchhof, Michael J., Niosi, Mark, Patel, Leena, Perreault, Christian, Tapley, Susan, Zavadoski, William J.

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A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder : Clinical pharmacology of functional disorders of the urogenital system by CALLEGARI, Ernesto, MALHOTRA, Bimal, BUNGAY, Peter J, WEBSTER, Rob, FENNER, Katherine S, KEMPSHALL, Sarah, LAPERLE, Jennifer L, MICHEL, Martin C, KAY, Gary G

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An Analytical Method for the Analysis of Tulathromycin, an Equilibrating Triamilide, in Bovine and Porcine Plasma and Lung by Gáler, Diana, Hessong, Scott, Beato, Brian, Risk, James, Inskeep, Philip, Weerasinghe, Chandralal, Schneider, Richard P, Langer, Connie, LaPerle, Jennifer, Renouf, Donald, Bessire, Andrew, Español, Eden, Rafka, Robert, Ragan, Colman, Boettner, Wayne, Murphy, Trisha, Keller, David, Benchaoui, Hafid, Nowakowski, Marcus A

“…Tulathromycin is a novel member of the triamilide class of antibiotics that was developed as a safe and effective single-dose treatment of bovine and porcine…”
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Impact of time-dependent inactivation on the estimation of enzyme kinetic parameters for midazolam by Giragossian, Craig, LaPerle, Jennifer, Kosa, Rachel E, Gillian, Sarah

“…Enzyme kinetic parameters for midazolam were time-dependent in human liver microsomes, under initial velocity conditions. V(max) and K(m) decreased up to 3.7…”
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