Search Results - "LaNoue, K. F."

Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia by Xu, Y., Ola, M. S., Berkich, D. A., Gardner, T. W., Barber, A. J., Palmieri, F., Hutson, S. M., LaNoue, K. F.

“…The mitochondrial transporter, the aspartate/glutamate carrier (AGC), is a necessary component of the malate/aspartate cycle, which promotes the transfer into…”
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Whole‐brain glutamate metabolism evaluated by steady‐state kinetics using a double‐isotope procedure: effects of gabapentin by Xu, Y., Öz, G., LaNoue, K. F., Keiger, C. J., Berkich, D. A., Gruetter, R., Hutson, S. H.

“…Cerebral rates of anaplerosis are known to be significant, yet the rates measured in vivo have been debated. In order to track glutamate metabolism in brain…”
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Role of Branched‐Chain Aminotransferase Isoenzymes and Gabapentin in Neurotransmitter Metabolism by Hutson, S. M., Berkich, D., Drown, P., Xu, Baiyang, Aschner, Michael, LaNoue, Kathryn F.

“…: Because it is well known that excess branched‐chain amino acids (BCAAs) have a profound influence on neurological function, studies were conducted to…”
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Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease by Zinnanti, William J., Lazovic, Jelena, Griffin, Kathleen, Skvorak, Kristen J., Paul, Harbhajan S., Homanics, Gregg E., Bewley, Maria C., Cheng, Keith C., LaNoue, Kathryn F., Flanagan, John M.

“…Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with life-threatening cerebral oedema and…”
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Effects of cardiac work on electrical potential gradient across mitochondrial membrane in perfused rat hearts by Wan, B, Doumen, C, Duszynski, J, Salama, G, Vary, T C, LaNoue, K F

“…The myocardium responds to alterations in cardiac work by changing its rate of O2 consumption. This reflects an increase in the oxidative synthesis of ATP to…”
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Mitochondrial transport proteins of the brain by Berkich, D.A., Ola, M.S., Cole, J., Sweatt, A.J., Hutson, S.M., LaNoue, K.F.

“…In this study, cellular distribution and activity of glutamate and γ‐aminobutyric acid (GABA) transport as well as oxoglutarate transport across brain…”
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Regulation of Citric Acid Cycle by Calcium by Wan, B, LaNoue, K F, Cheung, J Y, Scaduto, R C

“…The relationship of extramitochondrial Ca2+ to intramitochondrial Ca2+ and the influence of intramitochondrial free Ca2+ concentrations on various steps of the…”
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Role of Pyruvate Carboxylase in Facilitation of Synthesis of Glutamate and Glutamine in Cultured Astrocytes by Gamberino, William C., Berkich, Deborah A., Lynch, Christopher J., Xu, Baiyang, LaNoue, Kathryn F.

“…: CO2 fixation was measured in cultured astrocytes isolated from neonatal rat brain to test the hypothesis that the activity of pyruvate carboxylase influences…”
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Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components by Brown, L M, Fox, H L, Hazen, S A, LaNoue, K F, Rannels, S R, Lynch, C J

“…Primary rat adipocytes cultured in basement membrane component gels migrated and organized into large, three-dimensional, multicellular clusters. Gross…”
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Role of hepatic carbonic anhydrase in de novo lipogenesis by Lynch, C J, Fox, H, Hazen, S A, Stanley, B A, Dodgson, S, Lanoue, K F

“…The role of carbonic anhydrase in de novo lipid synthesis was examined by measuring [1-14C]acetate incorporation into total lipids, fatty acids and…”
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Effects of hindlimb contraction on pressor and muscle interstitial metabolite responses in the cat by MacLean, Dave A, LaNoue, Kathryn F, Gray, Kristen S, Sinoway, Lawrence I

“…1  Section of Cardiology and 2  Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, The Milton S. Hershey…”
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A multistep validation process of biomarkers for preclinical drug development by Freeman, W M, Bixler, G V, Brucklacher, R M, Lin, C-M, Patel, K M, VanGuilder, H D, LaNoue, K F, Kimball, S R, Barber, A J, Antonetti, D A, Gardner, T W, Bronson, S K

“…Biomarkers that can be measured in preclinical models in a high-throughput, reproducible manner offer the potential to increase the speed and efficacy of drug…”
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Altered Metabolite Exchange Between Subcellular Compartments in Intact Postischemic Rabbit Hearts by Lewandowski, E. Douglas, Yu, Xin, LaNoue, Kathryn F, White, Lawrence T, Doumen, Chris, O'Donnell, J. Michael

“…To examine metabolic regulation in postischemic hearts, we examined oxidative recycling of C within the glutamate pool (GLU) of intact rabbit hearts. Isolated…”
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A method of determining electrical potential gradient across mitochondrial membrane in perfused rat hearts by Wan, B, Doumen, C, Duszynski, J, Salama, G, LaNoue, K F

“…The electrical potential gradient across the mitochondrial membrane (delta psi m) in perfused rat hearts was estimated by calculating the equilibrium…”
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Determination of muscle-specific glucose flux using radioactive stereoisomers and microdialysis by MacLean, D A, Ettinger, S M, Sinoway, L I, Lanoue, K F

“…The purpose of the present study was to evaluate a novel approach for determining skeletal muscle-specific glucose flux using radioactive stereoisomers and the…”
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Nuclear calcium gradients in cultured rat hepatocytes by Waybill, M M, Yelamarty, R V, Zhang, Y L, Scaduto, Jr, R C, LaNoue, K F, Hsu, C J, Smith, B C, Tillotson, D L, Yu, F T, Cheung, J Y

“…Ca2+ concentrations ([Ca2+]) in cytosol and nucleus in fura-2-loaded cultured rat hepatocytes were determined by three-dimensional (3-D) optical-sectioning…”
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Function of leucine in excitatory neurotransmitter metabolism in the central nervous system by Hutson, S M, Lieth, E, LaNoue, K F

“…A novel hypothesis for the role of branched-chain amino acids (BCAA) in regulating levels of the major excitatory neurotransmitter glutamate in the central…”
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Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons by Nakamura, Makoto, Barber, Alistair J., Antonetti, David A., LaNoue, Kathryn F., Robinson, Katherine A., Buse, Maria G., Gardner, Thomas W.

“…In addition to microvascular abnormalities, neuronal apoptosis occurs early in diabetic retinopathy, but the mechanism is unknown. Insulin may act as a…”
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Potassium-channel opener cardioplegia is superior to St. Thomas’ solution in the intact animal by Jayawant, A.Mark, Stephenson, Edward R., Matte, Gregory S., Prophet, George A., LaNoue, Kathryn F., Griffith, James W., Damiano, Ralph J.

“…Background. In isolated hearts, the potassium-channel opener pinacidil is an effective cardioplegic agent. This study tested the hypothesis that pinacidil is…”
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Nitrogen shuttling between neurons and glial cells during glutamate synthesis by Lieth, Erich, LaNoue, Kathryn F., Berkich, Deborah A., Xu, Baiyang, Ratz, Michael, Taylor, Charles, Hutson, Susan M.

“…The relationship between neuronal glutamate turnover, the glutamate/glutamine cycle and de novo glutamate synthesis was examined using two different model…”
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