Search Results - "LaForce, Geneva R."

mRNA isoform balance in neuronal development and disease by LaForce, Geneva R., Philippidou, Polyxeni, Schaffer, Ashleigh E.

“…Balanced mRNA isoform diversity and abundance are spatially and temporally regulated throughout cellular differentiation. The proportion of expressed isoforms…”
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Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration by LaForce, Geneva R., Farr, Jordan S., Liu, Jingyi, Akesson, Cydni, Gumus, Evren, Pinkard, Otis, Miranda, Helen C., Johnson, Katherine, Sweet, Thomas J., Ji, Ping, Lin, Ai, Coller, Jeff, Philippidou, Polyxeni, Wagner, Eric J., Schaffer, Ashleigh E.

“…Tight regulation of mRNA isoform expression is essential for neuronal development, maintenance, and function; however, the repertoire of proteins that govern…”
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TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome by Werren, Elizabeth A., LaForce, Geneva R., Srivastava, Anshika, Perillo, Delia R., Li, Shaokun, Johnson, Katherine, Baris, Safa, Berger, Brandon, Regan, Samantha L., Pfennig, Christian D., de Munnik, Sonja, Pfundt, Rolph, Hebbar, Malavika, Jimenez-Heredia, Raúl, Karakoc-Aydiner, Elif, Ozen, Ahmet, Dmytrus, Jasmin, Krolo, Ana, Corning, Ken, Prijoles, E. J., Louie, Raymond J., Lebel, Robert Roger, Le, Thuy-Linh, Amiel, Jeanne, Gordon, Christopher T., Boztug, Kaan, Girisha, Katta M., Shukla, Anju, Bielas, Stephanie L., Schaffer, Ashleigh E.

“…THOC6 variants are the genetic basis of autosomal recessive THOC6 Intellectual Disability Syndrome (TIDS). THOC6 is critical for mammalian Transcription Export…”
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