Search Results - "LaFon, Stephen"

Safety and Pharmacokinetics of Abacavir (1592U89) following Oral Administration of Escalating Single Doses in Human Immunodeficiency Virus Type 1-Infected Adults by KUMAR, P. N, SWEET, D. E, MCDOWELL, J. A, SYMONDS, W, YU LOU, HETHERINGTON, S, LAFON, S

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Antiviral efficacy of abacavir in antiretroviral therapy-experienced adults harbouring HIV-1 with specific patterns of resistance to nucleoside reverse transcriptase inhibitors by LANIER, E. Randall, AIT-KHALED, Mounir, SPREEN, William, LAFON, Stephen, SCOTT, Janna, STONE, Chris, MELBY, Thomas, STURGE, Glenn, ST CLAIR, Marty, STEEL, Helen, HETHERINGTON, Seth, PEARCE, Gillian

“…To evaluate HIV-1 reverse transcriptase genotypic and phenotypic indicators of resistance to abacavir (ABC) as predictors of ABC antiviral efficacy. The study…”
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Comparison of Atovaquone (566C80) with Trimethoprim-Sulfamethoxazole to Treat Pneumocystis carinii Pneumonia in Patients with AIDS by Hughes, Walter, Leoung, Gifford, Kramer, Francoise, Bozzette, Samuel A, Safrin, Sharon, Frame, Peter, Clumeck, Nathan, Masur, Henry, Lancaster, Danny, Chan, Charles, Lavelle, James, Rosenstock, Joel, Falloon, Judith, Feinberg, Judith, LaFon, Stephen, Rogers, Michael, Sattler, Fred

“…More than half of patients with the acquired immunodeficiency syndrome (AIDS) have adverse effects when they are treated with either pentamidine or…”
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Antiretroviral effect and safety of abacavir alone and in combination with zidovudine in HIV-infected adults by SAAG, M. S, SONNERBORG, A, TORRES, R. A, LANCASTER, D, GAZZARD, B. G, SCHOOLEY, R. T, ROMERO, C, KELLEHER, D, SPREEN, W, LAFON, S

“…Objectives: To evaluate, over 12 weeks, the antiretroviral activity and safety of abacavir, used alone and in combination with zidovudine (ZDV), as treatment…”
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Adverse Events Associated with Trimethoprim-Sulfamethoxazole and Atovaquone during the Treatment of AIDS-Related Pneumocystis carinii Pneumonia by Hughes, Walter T., LaFon, Stephen W., Scott, Janna D., Masur, Henry

“…Atovaquone was compared to trimethoprim-sulfamethoxazole (TMP-SMZ) for the relationship of time receiving therapy, plasma drug concentrations, and incidence of…”
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Atovaquone Suspension in HIV-Infected Volunteers: Pharmacokinetics, Pharmacodynamics, and TMP-SMX Interaction Study by Falloon, Judith, Sargent, Susie, Piscitelli, Stephen C., Bechtel, Christine, LaFon, Stephen W., Sadler, Brian, Walker, Robert E., Kovacs, Joseph A., Polis, Michael A., Davey Jr, Richard T., Lane, H. Clifford, Masur, Henry

“…Study Objective. To evaluate the pharmacokinetics and safety of atovaquone suspension in volunteers infected with the human immunodeficiency virus ((HIV)…”
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A Preliminary Evaluation of 566C80 for the Treatment of Pneumocystis Pneumonia in Patients with the Acquired Immunodeficiency Syndrome by Falloon, Judith, Kovacs, Joseph, Hughes, Walter, O'Neill, Donna, Polis, Michael, Davey, Richard T, Rogers, Michael, LaFon, Stephen, Feuerstein, Irwin, Lancaster, Danny, Land, Mack, Tuazon, Carmelita, Dohn, Michael, Greenberg, Stephen, Lane, H. Clifford, Masur, Henry

“…THE investigational hydroxynaphthoquinone compound 566C80 is active against Toxoplasma gondii , plasmodium species, and Pneumocystis carinii in vitro and in…”
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Prophylactically Administered Retrovir® in Health Care Workers Potentially Exposed to the Human Immunodeficiency Virus by Lafon, Stephen W., Lehrman, Sandra Nusinoff, Barry, David W.

“…On 29 April 1988, Burroughs Wellcome initiated a double-blind, placebo-controlled trial in the United States to evaluate the potential effectiveness of…”
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Antiprotozoal activity of 3'-deoxyinosine. Inverse correlation to cleavage of the glycosidic bond by Moorman, A R, LaFon, S W, Nelson, D J, Carter, H H, Marr, J J, Berens, R L

“…Two nucleosides related to the known antiprotozoal agent 1-(beta-D-ribofuranosyl)-1,5-dihydro-4H-pyrazolo-[3,4-d]pyrimidine-4-one (allopurinol riboside, 1)…”
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Antileishmanial effect of allopurinol and allopurinol ribonucleoside on intracellular forms of Leishmania donovani by Berens, R L, Marr, J J, Nelson, D J, LaFon, S W

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6-THIOPURINE RIBOSIDE ANALOGS: THEIR TOXICITY AND METABOLISM IN LEISHMANIA DONOVANI AND MAMMALIAN CELLS: 107 by Lafon, Stephen W, Cohn, Naomi K, Nelson, Donald J, Berens, Randolph L

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Purine metabolism in Trypanosoma cruzi by Berens, R L, Marr, J J, LaFon, S W, Nelson, D J

“…Culture forms of Trypanosoma cruzi are incapable of synthesizing purines de novo from formate, glycine, or serine and require an exogenous purine for growth…”
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Antigiardial activity of guanine arabinoside. Mechanism studies by Miller, R L, Nelson, D J, LaFon, S W, Miller, W H, Krenitsky, T A

“…Guanine arabinoside (araG) inhibited the in vitro growth of Giardia lamblia WB with an ED50 value of 4 microM. The inhibition was prevented completely by…”
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Purine and pyrimidine salvage pathways in Leishmania donovani by LaFon, S W, Nelson, D J, Berens, R L, Marr, J J

“…Leishmania donovani, grown in culture, salvaged radiolabeled purine bases which were distributed into adenine and guanine ribonucleotides and into the RNA of…”
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The metabolism of formycin B in Leishmania donovani by Nelson, D J, Lafon, S W, Jones, T E, Spector, T, Berens, R L, Marr, J J

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Monophosphates of formycin B and allopurinol riboside. Interactions with leishmanial and mammalian succino-AMP synthetase and GMP reductase by Spector, T, Jones, T E, LaFon, S W, Nelson, D J, Berens, R L, Marr, J J

“…Formycin B 5'-monophosphate (Form B-MP) and allopurinol riboside 5'-monophosphate ( HPPR -MP) are isomers of IMP that are metabolically produced when…”
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Purine metabolism in the intact sporozoites and merozoites of Eimeria tenella by LaFon, S W, Nelson, D J

“…Intact Eimeria tenella sporozoites and merozoites did not incorporate radiolabeled formate or glycine into their purine nucleotides suggesting a lack of de…”
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Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism by Marr, J J, Berens, R L, Nelson, D J, Krenitsky, T A, Spector, T, LaFon, S W, Elion, G B

“…Thiopurinol [4-thiopyrazolo(3.4-dyprimidine, TPP] and its ribonucleoside (TPPR) were effective in vitro against the intracellular and extracellular forms of L…”
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6-Thiopurine riboside analogs: their toxicity and metabolism in Leishmania donovani and mammalian cells by LaFon, S W, Cohn, N K, Nelson, D J, Berens, R L

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Clinical experience with atovaquone on a treatment investigational new drug protocol for Pneumocystis carinii pneumonia by White, A, LaFon, S, Rogers, M, Andrews, E, Brown, N

“…The clinical experience of human immunodeficiency virus (HIV) + patients treated with oral atovaquone for acute Pneumocytstis carinii pneumonia (PCP) under a…”
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