Search Results - "LaFlamme, Christy W"

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs by Chapple, Richard H, Liu, Xueying, Natarajan, Sivaraman, Alexander, Margaret I M, Kim, Yuna, Patel, Anand G, LaFlamme, Christy W, Pan, Min, Wright, William C, Lee, Hyeong-Min, Zhang, Yinwen, Lu, Meifen, Koo, Selene C, Long, Courtney, Harper, John, Savage, Chandra, Johnson, Melissa D, Confer, Thomas, Akers, Walter J, Dyer, Michael A, Sheppard, Heather, Easton, John, Geeleher, Paul

“…Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy…”
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Leveraging multiple approaches for the detection of pathogenic deep intronic variants in developmental and epileptic encephalopathies: A case report by Nyaga, Denis M., Hildebrand, Michael S., Valles‐Ibáñez, Guillem, Keenan, Ngaire F., Ye, Zimeng, LaFlamme, Christy W., Mefford, Heather C., Bennett, Mark F., Bahlo, Melanie, Sadleir, Lynette G.

“…About 50% of individuals with developmental and epileptic encephalopathies (DEEs) are unsolved following genetic testing. Deep intronic variants, defined as…”
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Dyrk1a Mutations Cause Undergrowth of Cortical Pyramidal Neurons via Dysregulated Growth Factor Signaling by Levy, Jenna A., LaFlamme, Christy W., Tsaprailis, George, Crynen, Gogce, Page, Damon T.

“…Mutations in DYRK1A are a cause of microcephaly, autism spectrum disorder, and intellectual disability; however, the underlying cellular and molecular…”
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Diagnostic utility of DNA methylation analysis in genetically unsolved pediatric epilepsies and CHD2 episignature refinement by LaFlamme, Christy W., Rastin, Cassandra, Sengupta, Soham, Pennington, Helen E., Russ-Hall, Sophie J., Schneider, Amy L., Bonkowski, Emily S., Almanza Fuerte, Edith P., Allan, Talia J., Zalusky, Miranda Perez-Galey, Goffena, Joy, Gibson, Sophia B., Nyaga, Denis M., Lieffering, Nico, Hebbar, Malavika, Walker, Emily V., Darnell, Daniel, Olsen, Scott R., Kolekar, Pandurang, Djekidel, Mohamed Nadhir, Rosikiewicz, Wojciech, McConkey, Haley, Kerkhof, Jennifer, Levy, Michael A., Relator, Raissa, Lev, Dorit, Lerman-Sagie, Tally, Park, Kristen L., Alders, Marielle, Cappuccio, Gerarda, Chatron, Nicolas, Demain, Leigh, Genevieve, David, Lesca, Gaetan, Roscioli, Tony, Sanlaville, Damien, Tedder, Matthew L., Gupta, Sachin, Jones, Elizabeth A., Weisz-Hubshman, Monika, Ketkar, Shamika, Dai, Hongzheng, Worley, Kim C., Rosenfeld, Jill A., Chao, Hsiao-Tuan, Neale, Geoffrey, Carvill, Gemma L., Wang, Zhaoming, Berkovic, Samuel F., Sadleir, Lynette G., Miller, Danny E., Scheffer, Ingrid E., Sadikovic, Bekim, Mefford, Heather C.

“…Sequence-based genetic testing identifies causative variants in ~ 50% of individuals with developmental and epileptic encephalopathies (DEEs). Aberrant changes…”
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Abstract B006: An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs by Chapple, Richard H., Liu, Xueying, Natarajan, Sivaraman, Alexander, Margaret I.M., Kim, Yuna, Patel, Anand G., LaFlamme, Christy W., Pan, Min, Wright, William C., Lee, Hyeong-Min, Zhang, Yinwen, Lu, Meifen, Koo, Selene C., Long, Courtney, Harper, John, Savage, Chandra, Johnson, Melissa D., Confer, Thomas, Akers, Walter J., Dyer, Michael A., Sheppard, Heather, Easton, John, Geeleher, Paul

“…Preclinical models such as cell lines and mice are the backbone of drug development and experimental-mechanistic oncology. However, we currently lack a…”
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Abstract 868: A novel unsupervised machine learning model applied to neuroblastoma single-cell RNA-seq data reveals a drug-induced mesenchymal-like gene expression program by Chapple, Rich, Liu, Xueying, Natarajan, Sivaraman, Alexander, Margaret I., Kim, Yuna, Patel, Anand, LaFlamme, Christy W., Pan, Min, Wright, William C., Lee, Hyeong-Min, Zhang, Yinwen, Lu, Meifen, Koo, Selene C., Long, Courtney, Harper, John, Savage, Chandra, Johnson, Melissa D., Confer, Thomas, Akers, Walter J., Dyer, Michael A., Sheppard, Heather, Easton, John, Geeleher, Paul

“…High-risk neuroblastoma is one of the most difficult to treat pediatric cancers, with a survival rate of only about 50% and significant long-term consequences…”
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