Search Results - "LaFemina, Robert L"

Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay by LUDMERER, Steven W, GRAHAM, Donald J, LAFEMINA, Robert L, BOOTS, Evelyn, MURRAY, Edward M, SIMCOE, Amy, MARKEL, Eric J, GROBLER, Jay A, FLORES, Osvaldo A, OLSEN, David B, HAZUDA, Daria J

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Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors by LaFemina, Robert L

“…Two coronaviruses causing severe respiratory disease and high mortality rates emerging within the past dozen years reinforces the need for clinically…”
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Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro by Migliaccio, Giovanni, Tomassini, Joanne E., Carroll, Steven S., Tomei, Licia, Altamura, Sergio, Bhat, Balkrishen, Bartholomew, Linda, Bosserman, Michele R., Ceccacci, Alessandra, Colwell, Lawrence F., Cortese, Riccardo, De Francesco, Raffaele, Eldrup, Anne B., Getty, Krista L., Hou, Xiaoli S., LaFemina, Robert L., Ludmerer, Steven W., MacCoss, Malcolm, McMasters, Daniel R., Stahlhut, Mark W., Olsen, David B., Hazuda, Daria J., Flores, Osvaldo A.

“…The urgent need for efficacious drugs to treat chronic hepatitis C virus (HCV) infection requires a concerted effort to develop inhibitors specific for virally…”
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A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties by OLSEN, David B, ELDRUP, Anne B, GROBLER, Jay A, LAFEMINA, Robert L, MARKEL, Eric J, MIGLIACCIO, Giovanni, PRHAVC, Marija, STAHLHUT, Mark W, TOMASSINI, Joanne E, MACCOSS, Malcolm, HAZUDA, Daria J, CARROLL, Steven S, BARTHOLOMEW, Linda, BHAT, Balkrishen, BOSSERMAN, Michele R, CECCACCI, Alessandra, COLWELL, Lawrence F, FAY, John F, FLORES, Osvaldo A, GETTY, Krista L

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Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication by Eldrup, Anne B, Prhavc, Marija, Brooks, Jennifer, Bhat, Balkrishen, Prakash, Thazha P, Song, Quanlai, Bera, Sanjib, Bhat, Neelima, Dande, Prasad, Cook, P. Dan, Bennett, C. Frank, Carroll, Steven S, Ball, Richard G, Bosserman, Michele, Burlein, Christine, Colwell, Lawrence F, Fay, John F, Flores, Osvaldo A, Getty, Krista, LaFemina, Robert L, Leone, Joseph, MacCoss, Malcolm, McMasters, Daniel R, Tomassini, Joanne E, von Langen, Derek, Wolanski, Bohdan, Olsen, David B

“…Hepatitis C virus infection constitutes a significant health problem in need of more effective therapies. We have recently identified 2‘-C-methyladenosine and…”
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A genotype 2b NS5B polymerase with novel substitutions supports replication of a chimeric HCV 1b:2b replicon containing a genotype 1b NS3-5A background by Graham, Donald J., Stahlhut, Mark, Flores, Osvaldo, Olsen, David B., Hazuda, Daria J., LaFemina, Robert L., Ludmerer, Steven W.

“…HCV diversity suggests that evaluation of HCV inhibitors for broad genotypic efficacy is warrented. The replicon system enables cell-culture compound efficacy…”
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Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells by LAFEMINA, R. L, SCHNEIDER, C. L, ROBBINS, H. L, CALLAHAN, P. L, LEGROW, K, ROTH, E, SCHLEIF, W. A, EMINI, E. A

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Substrate specificity of recombinant human immunodeficiency virus integrase protein by LaFemina, R L, Callahan, P L, Cordingley, M G

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Sequence-Specific Interaction of Tat Protein and Tat Peptides with the Transactivation-Responsive Sequence Element of Human Immunodeficiency Virus Type 1 in vitro by Cordingley, Michael G., LaFemina, Robert L., Callahan, Pia L., Condra, Jon H., Sardana, Vinod V., Graham, Donald J., Nguyen, Tacy M., LeGrow, Kathleen, Gotlib, Leah, Schlabach, Abner J., Colonno, Richard J.

“…Bacterially expressed Tat protein of human immunodeficiency virus type 1 binds selectively to short RNA transcripts containing the viral…”
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Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase by BURKE, C. J, SANYAL, G, BRUNER, M. W, RYAN, J. A, LAFEMINA, R. L, ROBBINS, H. L, ZEFT, A. S, MIDDAUGH, C. R, CORDINGLEY, M. G

“…The N-terminal domain of human immunodeficiency virus (HIV-1) integrase (IN) contains the sequence motif His-Xaa3-His-Xaa23-Cys-Xaa2-Cys, which is strongly…”
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Expression of the acidic nuclear immediate-early protein (IE1) of human cytomegalovirus in stable cell lines and its preferential association with metaphase chromosomes by Lafemina, R L, Pizzorno, M C, Mosca, J D, Hayward, G S

“…Stable DNA-transfected Vero cell lines that express the major immediate-early nuclear antigen (IE68) of HCMV-(Towne) have been established. Immunofluorescence…”
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Peptide substrate cleavage specificity of the human cytomegalovirus protease by SARDANA, V. V, WOLFGANG, J. A, VELOSKI, C. A, LONG, W. J, LEGROW, K, WOLANSKI, B, EMINI, E. A, LAFEMINA, R. L

“…The human cytomegalovirus UL80 gene encodes an 80-kDa precursor polyprotein whose N-terminal 256-amino acid domain is a protease. This enzyme cleaves a…”
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Characterization of a soluble stable human cytomegalovirus protease and inhibition by M-site peptide mimics by LaFemina, R L, Bakshi, K, Long, W J, Pramanik, B, Veloski, C A, Wolanski, B S, Marcy, A I, Hazuda, D J

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Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase by HAZUDA, D. J, WOLFE, A. L, HASTINGS, J. C, ROBBINS, H. L, GRAHAM, P. L, LAFEMINA, R. L, EMINI, E. A

“…A DNA binding assay was developed for the human immunodeficiency virus type 1 (HIV-1) integrase. The assay was capable of defining discrete complexes between…”
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Human Immunodeficiency Virus Type 1 Protease Inhibitors: Evaluation of Resistance Engendered by Amino Acid Substitutions in the Enzyme's Substrate Binding Site by Sardana, Vinod V, Schlabach, Abner J, Graham, Pia, Bush, Bruce L, Condra, Jon H, Culberson, J. Chris, Gotlib, Leah, Graham, Donald J, Kohl, Nancy E

“…The human immunodeficiency virus type 1 (HIV-1) protease is a homodimeric aspartyl endopeptidase that is required for virus replication. A number of specific,…”
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Differences in Cell Type-specific Blocks to Immediate Early Gene Expression and DNA Replication of Human, Simian and Murine Cytomegalovirus by Lafemina, Robert L, Hayward, Gary S

“…The Virology Laboratories, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street,…”
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Purification of active herpes simplex virus-1 protease expressed in Escherichia coli by DARKE, P. L, CHEN, E, HALL, D. L, SARDANA, M. K, VELOSKI, C. A, LAFEMINA, R. L, SHAFER, J. A, KUO, L. C

“…Assembly of viral capsids for replication of herpes simplex virus requires the proteolytic processing of the assembly protein ICP35. The protease responsible…”
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Replicative Forms of Human Cytomegalovirus DNA with Joined Termini Are Found in Permissively Infected Human Cells But Not in Non-permissive Balb/c-3T3 Mouse Cells by LaFemina, Robert L, Hayward, Gary S

“…Department of Pharmacology and Experimental Therapeutics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205,…”
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Structural Organization of Human Herpesvirus DNA Molecules by Hayward, Gary S., Ambinder, Richard, Ciufo, Dolores, Hayward, S. Diane, LaFemina, Robert L.

“…Abstract only…”
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Structural Organization of Human Herpesvirus DNA Molecules by Hayward, Gary S., Ambinder, Richard, Ciufo, Dolores, Diane Hayward, S., Lafemina, Robert L.

“…The herpesviruses are among the largest and most complex of all DNA viruses, and their genomes display an astonishing diversity in size, structure, and…”
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