Search Results - "LaBonte Wilson, Melissa"

Particle swarm optimization artificial intelligence technique for gene signature discovery in transcriptomic cohorts by Murphy, Ross G., Gilmore, Alan, Senevirathne, Seedevi, O'Reilly, Paul G., LaBonte Wilson, Melissa, Jain, Suneil, McArt, Darragh G.

“…[Display omitted] •EBPSO identifies unique, accurate, and succinct gene signatures.•Key genes within the signatures provide biological insights its associated…”
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The pseudo-caspase FLIP(L) regulates cell fate following p53 activation by Lees, Andrea, McIntyre, Alexander J., Crawford, Nyree T., Falcone, Fiammetta, McCann, Christopher, Holohan, Caitriona, Quinn, Gerard P., Roberts, Jamie Z., Sessler, Tamas, Gallagher, Peter F., Gregg, Gemma M. A., McAllister, Katherine, McLaughlin, Kirsty M., Allen, Wendy L., Egan, Laurence J., Ryan, Aideen E., Labonte-Wilson, Melissa J., Dunne, Philip D., Wappett, Mark, Coyle, Vicky M., Johnston, Patrick G., Kerr, Emma M., Longley, Daniel B., McDade, Simon S.

“…p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the molecular basis of the switch from p53-induced cellcycle arrest to apoptosis…”
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Simultaneous integrated boost (SIB) to dominant intra-prostatic lesions during extreme hypofractionation for prostate cancer: the impact of rectal spacers by Osman, Sarah O S, Fairmichael, Ciaran, Whitten, Glenn, Lundy, Gavin S, Wesselman, Rachel, Wilson, Melissa LaBonte, Hounsell, Alan R, Prise, Kevin M, Irvine, Denise, McGarry, Conor K, Jain, Suneil

“…Boosting dominant intra-prostatic lesions (DILs) has the potential to increase the therapeutic ratio in prostate cancer radiotherapy. In this study, employing…”
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A modular, open-label, phase I/IIa study to evaluate the safety, tolerability, pharmacokinetics (PKs) and anti-tumour activity of a first-in-class (FIC) specific dUTPase inhibitor CV6-168 combined with anti-cancer treatments in patients (pts) with advanced malignancies by Coyle, Victoria, Plummer, Elizabeth Ruth, Banerji, Udai, Evans, T.R. Jeffry, Clack, Glen, Mulligan, Karl A, Wilson, Peter M., Barker, Tess, LaBonte Wilson, Melissa, Ladner, Robert D., Wilson, Richard H.

“…TPS3170 Background: CV6-168 is a FIC DNA uracilation agent targeting the enzyme dUTPase with high specificity. CV6-168 induces misincorporation of uracil into…”
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Abstract 3737: Targeting the YKL40 pathway inhibits monocyte-mediated cell migration of prostate cancer cells following radiotherapy treatment by Armstrong, Chris W., Wilson, Melissa LaBonte, Redmond, Kelly M., Jain, Suneil, Waugh, David J.

“…Abstract Introduction: Loss of the tumor suppressor PTEN is associated with relapse following radiotherapy (RT) in men with prostate cancer (PCa). We have…”
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Associations of prostate tumor immune landscape with vigorous physical activity and prostate cancer progression by Huang, Lanshan, Winter, Sarah J, Olsson, Linnea T, Hamilton, Alina M, Halliday, Sophia R, Kirk, Erin L, Farnan, Laura, Gerstel, Adrian, Craig, Stephanie G, Finn, Stephen P, LaBonte Wilson, Melissa, Jain, Suneil, Troester, Melissa A, Butler, Eboneé N, Bensen, Jeannette T, Wobker, Sara E, Allott, Emma H

“…Vigorous physical activity has been associated with lower risk of fatal prostate cancer. However, mechanisms contributing to this relationship are not…”
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Abstract A059: Epigenetic remodelling by class I HDAC inhibitors increases response to androgen signalling inhibitors in prostate cancer by McCole, Rachel, McCullough, Ben, Manley, Judith M., Forsythe, Nicholas, McDade, Simon S., Wilson, Melissa LaBonte

“…Abstract Prostate cancer (PCa) is one of the most prevalent cancers in the male population with approximately 1 in 8 men diagnosed with the disease during…”
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Abstract 2409: FLIP(L) determines colon cancer cell fate following p53 activation by Lees, Andrea, McIntyre, Alexander J. McIntyre J., Crawford, Nyree T., Falcone, Fiammetta, McCann, Chris, Quinn, Gerard P., Roberts, Jamie Z., Sessler, Thomas, Gallagher, Peter F., Gregg, Gemma M., McAllister, Katherine, McLaughlin, Kirsty M., Allen, Wendy L., Holohan, Caitriona, Egan, Laurence J., Ryan, Aideen E., Labonte-Wilson, Melissa, Dunne, Phillip D., Wappett, Mark, Coye, Vicky M., Johnston, Patrick G., Kerr, Emma M., Longley, Daniel B., McDade, Simon S.

“…Abstract Background: How p53 differentially activates cell cycle arrest versus cell death remains poorly understood. Understanding the mechanisms governing the…”
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Abstract 3836: Imbalanced nucleotide metabolism sensitizes breast cancer cells to anthracyclines by Davison, Craig, Chevallier, Olivier P., Knowlson, Catherine, McKechnie, Melanie, Carson, Robbie, Esteve, Jaime, Wilson, Richard, Ladner, Robert D., (Wilson), Melissa J. LaBonte

“…Abstract Introduction. Triple negative breast cancer (TNBC) makes up 15% of breast cancers and is associated with poor prognosis. TNBC treatment remains…”
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