Search Results - "La Rosa, Carmelo"

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  1. 1

    Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes by Milardi, Danilo, Gazit, Ehud, Radford, Sheena E, Xu, Yong, Gallardo, Rodrigo U, Caflisch, Amedeo, Westermark, Gunilla T, Westermark, Per, Rosa, Carmelo La, Ramamoorthy, Ayyalusamy

    Published in Chemical reviews (10-02-2021)
    “…The possible link between hIAPP accumulation and β-cell death in diabetic patients has inspired numerous studies focusing on amyloid structures and aggregation…”
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  2. 2

    Amyloidogenic Intrinsically Disordered Proteins: New Insights into Their Self-Assembly and Their Interaction with Membranes by Scollo, Federica, La Rosa, Carmelo

    Published in Life (Basel, Switzerland) (08-08-2020)
    “…Aβ, IAPP, α-synuclein, and prion proteins belong to the amyloidogenic intrinsically disordered proteins’ family; indeed, they lack well defined secondary and…”
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  3. 3

    The Role of Cholesterol in Driving IAPP-Membrane Interactions by Sciacca, Michele F.M., Lolicato, Fabio, Di Mauro, Giacomo, Milardi, Danilo, D’Urso, Luisa, Satriano, Cristina, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

    Published in Biophysical journal (12-07-2016)
    “…Our knowledge of the molecular events underlying type 2 diabetes mellitus—a protein conformational disease characterized by the aggregation of islet amyloid…”
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  4. 4

    Lipid-assisted protein transport: A diffusion-reaction model supported by kinetic experiments and molecular dynamics simulations by La Rosa, Carmelo, Scalisi, Silvia, Lolicato, Fabio, Pannuzzo, Martina, Raudino, Antonio

    Published in The Journal of chemical physics (14-05-2016)
    “…The protein transport inside a cell is a complex phenomenon that goes through several difficult steps. The facilitated transport requires sophisticated…”
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  5. 5

    Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP by Sciacca, Michele F.M., Milardi, Danilo, Messina, Grazia M.L., Marletta, Giovanni, Brender, Jeffrey R., Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

    Published in Biophysical journal (08-01-2013)
    “…Disruption of the integrity of the plasma membrane by amyloidogenic proteins is linked to the pathogenesis of a number of common age-related diseases. Although…”
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  6. 6

    The corona of protein-gold nanoparticle systems: the role of ionic strength by Cantarutti, Cristina, Hunashal, Yamanappa, La Rosa, Carmelo, Condorelli, Marcello, Giorgetti, Sofia, Bellotti, Vittorio, Fogolari, Federico, Esposito, Gennaro

    Published in Physical chemistry chemical physics : PCCP (19-01-2022)
    “…The nature of the nanoparticle-protein corona is emerging as a key aspect in determining the impact of nanomaterials on proteins and in general on the…”
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  7. 7
  8. 8

    Influence of Free Fatty Acids on Lipid Membrane–Nisin Interaction by Saitta, Francesca, Motta, Paolo, Barbiroli, Alberto, Signorelli, Marco, La Rosa, Carmelo, Janaszewska, Anna, Klajnert-Maculewicz, Barbara, Fessas, Dimitrios

    Published in Langmuir (17-11-2020)
    “…The influence of free fatty acids (FFAs) on the nisin–membrane interaction was investigated through micro-DSC and fluorescence spectroscopy. A simple but…”
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  9. 9
  10. 10

    Self‐Assembly and Neurotoxicity of β‐Amyloid (21–40) Peptide Fragment: The Regulatory Role of GxxxG Motifs by Sarkar, Dibakar, Chakraborty, Ipsita, Condorelli, Marcello, Ghosh, Baijayanti, Mass, Thorben, Weingarth, Markus, Mandal, Atin K, La Rosa, Carmelo, Subramanian, Vivekanandan, Bhunia, Anirban

    Published in ChemMedChem (05-02-2020)
    “…The three GxxxG repeating motifs from the C‐terminal region of β‐amyloid (Aβ) peptide play a significant role in regulating the aggregation kinetics of the…”
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  11. 11

    Symmetry-breaking transitions in the early steps of protein self-assembly by La Rosa, Carmelo, Condorelli, Marcello, Compagnini, Giuseppe, Lolicato, Fabio, Milardi, Danilo, Do, Trang Nhu, Karttunen, Mikko, Pannuzzo, Martina, Ramamoorthy, Ayyalusamy, Fraternali, Franca, Collu, Francesca, Rezaei, Human, Strodel, Birgit, Raudino, Antonio

    Published in European biophysics journal (01-03-2020)
    “…Protein misfolding and subsequent self-association are complex, intertwined processes, resulting in development of a heterogeneous population of aggregates…”
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  12. 12

    GxxxG Motif Stabilize Ion-Channel like Pores through C α -H···O Interaction in Aβ (1-40) by Rando, Carola, Grasso, Giuseppe, Sarkar, Dibakar, Sciacca, Michele Francesco Maria, Cucci, Lorena Maria, Cosentino, Alessia, Forte, Giuseppe, Pannuzzo, Martina, Satriano, Cristina, Bhunia, Anirban, La Rosa, Carmelo

    “…Aβ (1-40) can transfer from the aqueous phase to the bilayer and thus form stable ion-channel-like pores where the protein has alpha-helical conformation. The…”
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  13. 13

    Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide by Brender, Jeffrey R, Krishnamoorthy, Janarthanan, Messina, Grazia M L, Deb, Aniruddha, Vivekanandan, Subramanian, La Rosa, Carmelo, Penner-Hahn, James E, Ramamoorthy, Ayyalusamy

    “…The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been…”
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  14. 14

    Amyloid-Mediated Mechanisms of Membrane Disruption by Sciacca, Michele F. M., La Rosa, Carmelo, Milardi, Danilo

    Published in Biophysica (01-06-2021)
    “…Protein aggregation and amyloid formation are pathogenic events underlying the development of an increasingly large number of human diseases named…”
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  15. 15

    The role of the Cys2-Cys7 disulfide bridge in the early steps of Islet amyloid polypeptide aggregation: A molecular dynamics study by Milardi, Danilo, Pappalardo, Matteo, Pannuzzo, Martina, Grasso, Domenico M., Rosa, Carmelo La

    Published in Chemical physics letters (01-10-2008)
    “…The rupture of the Cys2-Cys7 disulfide bridge decreases the stability and increases the β-sheet content of early IAPP aggregates. Aggregation of Islet amyloid…”
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  16. 16

    Calcium-activated membrane interaction of the islet amyloid polypeptide: Implications in the pathogenesis of type II diabetes mellitus by Sciacca, Michele F.M., Pappalardo, Matteo, Milardi, Danilo, Grasso, Domenico M., Rosa, Carmelo La

    Published in Archives of biochemistry and biophysics (15-09-2008)
    “…The role played by Ca 2+ ions in the interaction of the human islet amyloid polypeptide (hIAPP) with model membranes has been investigated by differential…”
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  17. 17

    role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH by Milardi, Danilo, Sciacca, Michele F. M, Pappalardo, Matteo, Grasso, Domenico M, La Rosa, Carmelo

    Published in European biophysics journal (01-01-2011)
    “…Human islet amyloid polypeptide (hIAPP) is known to misfold and aggregate into amyloid deposits that may be found in pancreatic tissues of patients affected by…”
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  18. 18

    Self-Assembling Pathway of HiApp Fibrils within Lipid Bilayers by Scalisi, Silvia, Sciacca, Michele F.M, Zhavnerko, Genady, Grasso, Domenico M, Marletta, Giovanni, La Rosa, Carmelo

    “…A combination of atomic force microscopy, quartz crystal microbalance and fluorescence spectroscopy shed light on the mechanism of interaction of hIAPP with…”
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  19. 19

    Environmental Factors Differently Affect Human and Rat IAPP: Conformational Preferences and Membrane Interactions of IAPP17-29 Peptide Derivatives by Pappalardo, Giuseppe, Milardi, Danilo, Magrì, Antonio, Attanasio, Francesco, Impellizzeri, Giuseppe, LaRosa, Carmelo, Grasso, Domenico, Rizzarelli, Enrico

    Published in Chemistry : a European journal (01-01-2007)
    “…Interest in the 37‐residue human islet amyloid polypeptide (hIAPP) is related to its ability to form amyloid deposits in patients affected by type II diabetes…”
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  20. 20

    Abnormal troponin I levels in acute pulmonary embolism without abnormal concentrations of D-dimer at admission by Patanè, Salvatore, Marte, Filippo, La Rosa, Felice Carmelo, Di Bella, Gianluca, La Rocca, Roberto, Villari, Santa Alessandra

    Published in International journal of cardiology (07-01-2010)
    “…Abstract Serum troponin I is a sensitive indicator of myocardial damage but abnormal troponin I levels have been reported without acute coronary syndrome and…”
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