Search Results - "La Rosa, Carmelo"
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Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes
Published in Chemical reviews (10-02-2021)“…The possible link between hIAPP accumulation and β-cell death in diabetic patients has inspired numerous studies focusing on amyloid structures and aggregation…”
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Amyloidogenic Intrinsically Disordered Proteins: New Insights into Their Self-Assembly and Their Interaction with Membranes
Published in Life (Basel, Switzerland) (08-08-2020)“…Aβ, IAPP, α-synuclein, and prion proteins belong to the amyloidogenic intrinsically disordered proteins’ family; indeed, they lack well defined secondary and…”
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The Role of Cholesterol in Driving IAPP-Membrane Interactions
Published in Biophysical journal (12-07-2016)“…Our knowledge of the molecular events underlying type 2 diabetes mellitus—a protein conformational disease characterized by the aggregation of islet amyloid…”
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Lipid-assisted protein transport: A diffusion-reaction model supported by kinetic experiments and molecular dynamics simulations
Published in The Journal of chemical physics (14-05-2016)“…The protein transport inside a cell is a complex phenomenon that goes through several difficult steps. The facilitated transport requires sophisticated…”
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Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP
Published in Biophysical journal (08-01-2013)“…Disruption of the integrity of the plasma membrane by amyloidogenic proteins is linked to the pathogenesis of a number of common age-related diseases. Although…”
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The corona of protein-gold nanoparticle systems: the role of ionic strength
Published in Physical chemistry chemical physics : PCCP (19-01-2022)“…The nature of the nanoparticle-protein corona is emerging as a key aspect in determining the impact of nanomaterials on proteins and in general on the…”
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Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins
Published in ACS chemical neuroscience (16-12-2020)“…An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin,…”
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Influence of Free Fatty Acids on Lipid Membrane–Nisin Interaction
Published in Langmuir (17-11-2020)“…The influence of free fatty acids (FFAs) on the nisin–membrane interaction was investigated through micro-DSC and fluorescence spectroscopy. A simple but…”
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Probing the Sources of the Apparent Irreproducibility of Amyloid Formation: Drastic Changes in Kinetics and a Switch in Mechanism Due to Micellelike Oligomer Formation at Critical Concentrations of IAPP
Published in The journal of physical chemistry. B (19-02-2015)“…The aggregation of amyloidogenic proteins is infamous for being highly chaotic, with small variations in conditions sometimes leading to large changes in…”
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Self‐Assembly and Neurotoxicity of β‐Amyloid (21–40) Peptide Fragment: The Regulatory Role of GxxxG Motifs
Published in ChemMedChem (05-02-2020)“…The three GxxxG repeating motifs from the C‐terminal region of β‐amyloid (Aβ) peptide play a significant role in regulating the aggregation kinetics of the…”
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11
Symmetry-breaking transitions in the early steps of protein self-assembly
Published in European biophysics journal (01-03-2020)“…Protein misfolding and subsequent self-association are complex, intertwined processes, resulting in development of a heterogeneous population of aggregates…”
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GxxxG Motif Stabilize Ion-Channel like Pores through C α -H···O Interaction in Aβ (1-40)
Published in International journal of molecular sciences (22-01-2023)“…Aβ (1-40) can transfer from the aqueous phase to the bilayer and thus form stable ion-channel-like pores where the protein has alpha-helical conformation. The…”
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13
Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide
Published in Chemical communications (Cambridge, England) (01-01-2013)“…The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been…”
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Amyloid-Mediated Mechanisms of Membrane Disruption
Published in Biophysica (01-06-2021)“…Protein aggregation and amyloid formation are pathogenic events underlying the development of an increasingly large number of human diseases named…”
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The role of the Cys2-Cys7 disulfide bridge in the early steps of Islet amyloid polypeptide aggregation: A molecular dynamics study
Published in Chemical physics letters (01-10-2008)“…The rupture of the Cys2-Cys7 disulfide bridge decreases the stability and increases the β-sheet content of early IAPP aggregates. Aggregation of Islet amyloid…”
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16
Calcium-activated membrane interaction of the islet amyloid polypeptide: Implications in the pathogenesis of type II diabetes mellitus
Published in Archives of biochemistry and biophysics (15-09-2008)“…The role played by Ca 2+ ions in the interaction of the human islet amyloid polypeptide (hIAPP) with model membranes has been investigated by differential…”
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role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH
Published in European biophysics journal (01-01-2011)“…Human islet amyloid polypeptide (hIAPP) is known to misfold and aggregate into amyloid deposits that may be found in pancreatic tissues of patients affected by…”
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18
Self-Assembling Pathway of HiApp Fibrils within Lipid Bilayers
Published in Chembiochem : a European journal of chemical biology (03-09-2010)“…A combination of atomic force microscopy, quartz crystal microbalance and fluorescence spectroscopy shed light on the mechanism of interaction of hIAPP with…”
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Environmental Factors Differently Affect Human and Rat IAPP: Conformational Preferences and Membrane Interactions of IAPP17-29 Peptide Derivatives
Published in Chemistry : a European journal (01-01-2007)“…Interest in the 37‐residue human islet amyloid polypeptide (hIAPP) is related to its ability to form amyloid deposits in patients affected by type II diabetes…”
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Abnormal troponin I levels in acute pulmonary embolism without abnormal concentrations of D-dimer at admission
Published in International journal of cardiology (07-01-2010)“…Abstract Serum troponin I is a sensitive indicator of myocardial damage but abnormal troponin I levels have been reported without acute coronary syndrome and…”
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