Search Results - "La Regina, Giuseppe"

RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota by Liu, Te, Wu, Jianchao, Han, Changpeng, Gong, Zhangbin, Regina, Giuseppe La, Chen, Jiulin, Dou, Fangfang, Silvestri, Romano, Chen, Chuan, Yu, Zhihua

“…An inflammatory cytokine storm is considered an important cause of death in severely and critically ill COVID-19 patients, however, the relationship between…”
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Looking for an Active Conformation of the Future HIV Type-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Regina, Giuseppe La, Coluccia, Antonio, Silvestri, Romano

“…HIV type-1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key drugs of highly active antiretroviral therapy (HAART) in the clinical…”
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Venting-while-Heating Microwave-Assisted Synthesis of 3-Arylthioindoles by La Regina, Giuseppe, Gatti, Valerio, Famiglini, Valeria, Piscitelli, Francesco, Silvestri, Romano

“…We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent…”
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Targeting the Interaction between the SH3 Domain of Grb2 and Gab2 by Malagrinò, Francesca, Coluccia, Antonio, Bufano, Marianna, Regina, Giuseppe La, Puxeddu, Michela, Toto, Angelo, Visconti, Lorenzo, Paone, Alessio, Magnifico, Maria Chiara, Troilo, Francesca, Cutruzzolà, Francesca, Silvestri, Romano, Gianni, Stefano

“…Gab2 is a scaffolding protein, overexpressed in many types of cancers, that plays a key role in the formation of signaling complexes involved in cellular…”
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Targeting CBP and p300: Emerging Anticancer Agents by Masci, Domiziana, Puxeddu, Michela, Silvestri, Romano, La Regina, Giuseppe

“…CBP and p300 are versatile transcriptional co-activators that play essential roles in regulating a wide range of signaling pathways, including Wnt/β-catenin,…”
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Metabolic Rewiring in Cancer: Small Molecule Inhibitors in Colorectal Cancer Therapy by Masci, Domiziana, Puxeddu, Michela, Silvestri, Romano, La Regina, Giuseppe

“…Alterations in cellular metabolism, such as dysregulation in glycolysis, lipid metabolism, and glutaminolysis in response to hypoxic and low-nutrient…”
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Emerging Therapeutic Agents for Colorectal Cancer by Nalli, Marianna, Puxeddu, Michela, La Regina, Giuseppe, Gianni, Stefano, Silvestri, Romano

“…There are promising new therapeutic agents for CRC patients, including novel small-molecule inhibitors and immune checkpoint blockers. We focused on emerging…”
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Emerging Direct Targeting β-Catenin Agents by Nalli, Marianna, Masci, Domiziana, Urbani, Andrea, La Regina, Giuseppe, Silvestri, Romano

“…Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct…”
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Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment by Masci, Domiziana, Naro, Chiara, Puxeddu, Michela, Urbani, Andrea, Sette, Claudio, La Regina, Giuseppe, Silvestri, Romano

“…Triple-negative breast cancer (TNBC) is one of the most heterogeneous and aggressive breast cancer subtypes with a high risk of death on recurrence. To date,…”
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Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments by Stornaiuolo, Mariano, Bruno, Agostino, Botta, Lorenzo, Regina, Giuseppe La, Cosconati, Sandro, Silvestri, Romano, Marinelli, Luciana, Novellino, Ettore

“…A Cannabinoid Receptor 1 (CB 1 ) binding site for the selective allosteric modulator ORG27569 is here identified through an integrate approach of consensus…”
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Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile by SILVESTRI, Romano, LIGRESTI, Alessia, CARAI, Mauro Antonio Maria, NOVELLINO, Ettore, COLOMBO, Giancarlo, DI MARZO, Vincenzo, CORELLI, Federico, LA REGINA, Giuseppe, PISCITELLI, Francesco, GATTI, Valerio, BRIZZI, Antonella, PASQUINI, Serena, LAVECCHIA, Antonio, ALLARA, Marco, FANTINI, Noemi

“…New substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized by replacing the 2,4-dichlorobenzyl and cyclohexyl moieties at the…”
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A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations by Mammone, Francesca Romana, Zanitti, Leo, Puxeddu, Michela, La Regina, Giuseppe, Silvestri, Romano, Borioni, Anna, Cirilli, Roberto

“…A key step in the development of medicinal products is the research and validation of selective and sensitive analytical methods for the control of impurities…”
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Mechanism of Interaction of Novel Indolylarylsulfone Derivatives with K103N and Y181I Mutant HIV-1 Reverse Transcriptase in Complex with its Substrates by Samuele, Alberta, Bisi, Sara, Kataropoulou, Alexandra, Regina, Giuseppe La, Piscitelli, Francesco, Gatti, Valerio, Silvestri, Romano, Maga, Giovanni

“…Background: Novel indolylarylsulfones (lASs), designed through rational structure-based molecular modelling and docking approaches, have been recently…”
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Biological evaluation of [4‐(4‐aminophenyl)‐1‐(4‐fluorophenyl)‐1 H ‐pyrrol‐3‐yl](3,4,5‐trimethoxyphenyl)methanone as potential antineoplastic agent in 2D and 3D breast cancer models by Mazzoccoli, Carmela, Crispo, Fabiana, Laurenzana, Ilaria, Pietrafesa, Michele, Sisinni, Lorenza, Lerose, Rosa, Telesca, Donatella, Milella, Maria R., Liu, Te, Della Sala, Gerardo, Sebastiani, Jessica, Silvestri, Romano, La Regina, Giuseppe

“…Abstract Targeting tubulin polymerization and depolymerization represents a promising approach to treat solid tumors. In this study, we investigated the…”
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Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B by Pippa, Simone, Mannironi, Cecilia, Licursi, Valerio, Bombardi, Luca, Colotti, Gianni, Cundari, Enrico, Mollica, Adriano, Coluccia, Antonio, Naccarato, Valentina, La Regina, Giuseppe, Silvestri, Romano, Negri, Rodolfo

“…: KDM5 enzymes are H3K4 specific histone demethylases involved in transcriptional regulation and DNA repair. These proteins are overexpressed in different…”
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β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy by Saponaro, Concetta, Sergio, Sara, Coluccia, Antonio, De Luca, Maria, La Regina, Giuseppe, Mologni, Luca, Famiglini, Valeria, Naccarato, Valentina, Bonetti, Daniela, Gautier, Candice, Gianni, Stefano, Vergara, Daniele, Salzet, Michel, Fournier, Isabelle, Bucci, Cecilia, Silvestri, Romano, Passerini, Carlo Gambacorti, Maffia, Michele, Coluccia, Addolorata Maria Luce

“…Nuclear activated β -catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring…”
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Toward Highly Potent Cancer Agents by Modulating the C‑2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors by La Regina, Giuseppe, Bai, Ruoli, Rensen, Whilelmina Maria, Di Cesare, Erica, Coluccia, Antonio, Piscitelli, Francesco, Famiglini, Valeria, Reggio, Alessia, Nalli, Marianna, Pelliccia, Sveva, Da Pozzo, Eleonora, Costa, Barbara, Granata, Ilaria, Porta, Amalia, Maresca, Bruno, Soriani, Alessandra, Iannitto, Maria Luisa, Santoni, Angela, Li, Junjie, Miranda Cona, Marlein, Chen, Feng, Ni, Yicheng, Brancale, Andrea, Dondio, Giulio, Vultaggio, Stefania, Varasi, Mario, Mercurio, Ciro, Martini, Claudia, Hamel, Ernest, Lavia, Patrizia, Novellino, Ettore, Silvestri, Romano

“…New arylthioindole derivatives having different cyclic substituents at position 2 of the indole were synthesized as anticancer agents. Several compounds…”
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Sulfonamide Inhibitors of β‐Catenin Signaling as Anticancer Agents with Different Output on c‐MYC by Di Magno, Laura, Di Pastena, Fiorella, Puxeddu, Michela, La Regina, Giuseppe, Coluccia, Antonio, Ciogli, Alessia, Manetto, Simone, Maroder, Marella, Canettieri, Gianluca, Silvestri, Romano, Nalli, Marianna

“…The Wnt/β‐catenin pathway is often found deregulated in cancer. The aberrant accumulation of β‐catenin in the cell nucleus results in the development of…”
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Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer by Nardella, Caterina, Visconti, Lorenzo, Malagrinò, Francesca, Pagano, Livia, Bufano, Marianna, Nalli, Marianna, Coluccia, Antonio, La Regina, Giuseppe, Silvestri, Romano, Gianni, Stefano, Toto, Angelo

“…The interaction between proteins is a fundamental event for cellular life that is generally mediated by specialized protein domains or modules. PDZ domains are…”
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AN IMPROVED SYNTHESIS OF ETHYL 5-CHLORO-4-FLUORO-1H-INDOLE-2-CARBOXYLATE by Piscitelli, Francesco, Regina, Giuseppe La, Silvestri, Romano

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