Search Results - "La Manna, P."

Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis by Ciccia, Francesco, Guggino, Giuliana, Rizzo, Aroldo, Manzo, Antonio, Vitolo, Barbara, La Manna, Marco Pio, Giardina, Giuseppina, Sireci, Guido, Dieli, Francesco, Montecucco, Carlo Maurizio, Alessandro, Riccardo, Triolo, Giovanni

“…IL-9 has been shown to be upregulated before the clinical onset of articular disease in RA. The exact role of IL-9 and Th9 cells in RA, however, has not yet…”
Get full text

Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis by La Manna, Marco P, Orlando, Valentina, Tamburini, Bartolo, Badami, Giusto D, Dieli, Francesco, Caccamo, Nadia

“…Even if the incidence of tuberculosis (TB) has been decreasing over the last years, the number of patients with TB is increasing worldwide. The emergence of…”
Get full text

Delivery of Mycobacterium tuberculosis epitopes by Bordetella pertussis adenylate cyclase toxoid expands HLA-E-restricted cytotoxic CD8 + T cells by Badami, Giusto D, La Manna, Marco P, Di Carlo, Paola, Stanek, Ondrej, Linhartova, Irena, Caccamo, Nadia, Sebo, Peter, Dieli, Francesco

“…Tuberculosis (TB) remains the first cause of death from infection caused by a bacterial pathogen. Chemotherapy does not eradicate (Mtb) from human lungs, and…”
Get full text

IL-21 regulates the differentiation of a human γδ T cell subset equipped with B cell helper activity by Caccamo, Nadia, Todaro, Matilde, La Manna, Marco P, Sireci, Guido, Stassi, Giorgio, Dieli, Francesco

“…Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and display pleiotropic features. Here we report that coculture of…”
Get full text

Spatiotemporal mapping of the leprosy granuloma landscape by La Manna, Marco P., Dieli, Francesco, Caccamo, Nadia

Get full text

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease by Orlando, Valentina, La Manna, Marco P, Goletti, Delia, Palmieri, Fabrizio, Lo Presti, Elena, Joosten, Simone A, La Mendola, Carmela, Buccheri, Simona, Ottenhoff, Tom H M, Dieli, Francesco, Caccamo, Nadia

“…T-cell-mediated immune responses play a fundamental role in controlling ( ) infection, and traditionally, this response is thought to be mediated by Th1-type…”
Get full text

Damping Excessive Inflammation and Tissue Damage in Mycobacterium tuberculosis Infection by Toll IL-1 Receptor 8/Single Ig IL-1-Related Receptor, a Negative Regulator of IL-1/TLR Signaling by Garlanda, Cecilia, Di Liberto, Diana, Vecchi, Annunciata, La Manna, Marco P, Buracchi, Chiara, Caccamo, Nadia, Salerno, Alfredo, Dieli, Francesco, Mantovani, Alberto

“…Toll IL-1R 8/single Ig IL-1-related receptor (TIR8/SIGIRR) is a member of the IL-1R family, expressed by epithelial tissues and immature dendritic cells, and…”
Get full text

Impact of Mycobacterium tuberculosis Infection on Human B Cell Compartment and Antibody Responses by La Manna, Marco P, Shekarkar-Azgomi, Mojtaba, Badami, Giusto D, Tamburini, Bartolo, Dieli, Costanza, Di Carlo, Paola, Fasciana, Teresa, Marcianò, Vito, Lo Sasso, Bruna, Giglio, Rosaria V, Giammanco, Anna, Ciaccio, Marcello, Dieli, Francesco, Caccamo, Nadia

“…Tuberculosis (TB) remains one of the most important health challenges worldwide. Control of the TB epidemic has not yet been achieved because of the lack of an…”
Get full text

Pivotal Advance: α-Galactosylceramide induces protection against lipopolysaccharide-induced shock by Sireci, Guido, La Manna, Marco P., Di Sano, Caterina, Di Liberto, Diana, Porcelli, Steven A., Kronenberg, Mitch, Dieli, Francesco, Salerno, Alfredo

“…α−galactosylceramide, a natural killer T cell ligand, and its synthetic homolog, KRN7000, consistently influence IFN‐γ and TNF‐α release, both mediators of…”
Get full text

Water sorption thermodynamics in glassy polymers endowed with hydrogen bonding interactions by Scherillo, G., La Manna, P., Musto, P., Mensitieri, G.

“…In this contribution, we review and critically compare the results of the analyses we have previously performed on water sorption thermodynamics in a series of…”
Get full text

Hyperspectral Raman imaging of human prostatic cells: An attempt to differentiate normal and malignant cell lines by univariate and multivariate data analysis by Musto, P., Calarco, A., Pannico, M., La Manna, P., Margarucci, S., Tafuri, A., Peluso, G.

“…Hyperspectral Raman images of human prostatic cells have been collected and analysed with several approaches to reveal differences among normal and tumor cell…”
Get full text

Permanent Loss of Human Leukocyte Antigen E–restricted CD8 + T Stem Memory Cells in Human Tuberculosis by Shekarkar Azgomi, Mojtaba, La Manna, Marco P., Sullivan, Lucy C., Brooks, Andrew G., Di Carlo, Paola, Dieli, Francesco, Caccamo, Nadia

Get full text

Platelets accumulate in lung lesions of tuberculosis patients and inhibit T‐cell responses and Mycobacterium tuberculosis replication in macrophages by La Manna, Marco P., Orlando, Valentina, Badami, Giusto D., Tamburini, Bartolo, Shekarkar Azgomi, Mojtaba, Lo Presti, Elena, del Nonno, Franca, Petrone, Linda, Belmonte, Beatrice, Falasca, Laura, Di Carlo, Paola, Dieli, Francesco, Goletti, Delia, Caccamo, Nadia

“…Platelets regulate human inflammatory responses that lead to disease. However, the role of platelets in tuberculosis (TB) pathogenesis is still unclear. Here,…”
Get full text

Phosphatidylserine Liposomes Reduce Inflammatory Response, Mycobacterial Viability, and HIV Replication in Coinfected Human Macrophages by Poerio, Noemi, Caccamo, Nadia R, La Manna, Marco P, Olimpieri, Tommaso, De Angelis, Lucia Henrici, D’Andrea, Marco M, Dieli, Francesco, Fraziano, Maurizio

“…Abstract Chronic immune activation is the key pathogenetic event of Mycobacterium tuberculosis-human immunodeficiency virus (HIV) coinfection. We assessed the…”
Get full text

An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis by Paterson, Rachel L, La Manna, Marco P, Arena De Souza, Victoria, Walker, Andrew, Gibbs-Howe, Dawn, Kulkarni, Rakesh, Fergusson, Joannah R, Mulakkal, Nitha Charles, Monteiro, Mauro, Bunjobpol, Wilawan, Dembek, Marcin, Martin-Urdiroz, Magdalena, Grant, Tressan, Barber, Claire, Garay-Baquero, Diana J, Tezera, Liku Bekele, Lowne, David, Britton-Rivet, Camille, Pengelly, Robert, Chepisiuk, Natalia, Singh, Praveen K, Woon, Amanda P, Powlesland, Alex S, McCully, Michelle L, Caccamo, Nadia, Salio, Mariolina, Badami, Giusto Davide, Dorrell, Lucy, Knox, Andrew, Robinson, Ross, Elkington, Paul, Dieli, Francesco, Lepore, Marco, Leonard, Sarah, Godinho, Luis F

“…Peptides presented by HLA-E, a molecule with very limited polymorphism, represent attractive targets for T cell receptor (TCR)-based immunotherapies to…”
Get full text

Detection of Natural Killer T Cells in Mice Infected with Rickettsia conorii by La Manna, M. P., Torina, A., Agnone, A., Blanda, V., Caracappa, S., Alongi, A., Di Marco, V., Giudice, E., Dieli, F., Sireci, G.

“…Summary Little information is available regarding the role of natural killer T (NKT) cells during the early stage of Rickettsia conorii infection. Herein,…”
Get full text

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA‐E during active tuberculosis and express type 2 cytokines by Caccamo, Nadia, Pietra, Gabriella, Sullivan, Lucy C., Brooks, Andrew G., Prezzemolo, Teresa, Manna, Marco P., Di Liberto, Diana, Joosten, Simone A., Meijgaarden, Krista E., Di Carlo, Paola, Titone, Lucina, Moretta, Lorenzo, Mingari, Maria C., Ottenhoff, Tom H. M., Dieli, Francesco

“…CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M. tuberculosis reactive CD8 T cells typically recognize peptides…”
Get full text

Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease by Guggino, Giuliana, Orlando, Valentina, Cutrera, Stella, La Manna, Marco P, Di Liberto, Diana, Vanini, Valentina, Petruccioli, Elisa, Dieli, Francesco, Goletti, Delia, Caccamo, Nadia

“…Highlights • In our study we have investigated the potential role of granzyme A levels in plasma obtained from stimulated whole blood, as biomarker of…”
Get full text

Timing of activation of CD4+ memory cells as a possible marker to establish the efficacy of vaccines against contagious agalactia in sheep by Agnone, Annalisa, La Manna, Marco P., Loria, Guido R., Puleio, Roberto, Villari, Sara, Nicholas, Robin A.J., Guggino, Giuliana, Sireci, Guido

“…Mycoplasma agalactiae is a major pathogen of sheep and goats in many areas of the world and particularly in Mediterranean countries. It causes contagious…”
Get full text

Molecular interactions of CO2 with the CuBTC metal organic framework: An FTIR study based on two-dimensional correlation spectroscopy by Musto, P., La Manna, P., Pannico, M., Mensitieri, G., Gargiulo, N., Caputo, D.

“…The sorption of Carbon dioxide in the prototype metal-organic framework CuBTC was examined in detail by FTIR spectroscopy. The spectra were collected in-situ…”
Get full text