Search Results - "La Kim, Eun"
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Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites
Published in European journal of medicinal chemistry (15-10-2019)“…The aim of this study was to design and synthesize COX-1/COX-2 balanced inhibitors incorporating the structural motifs of anti-inflammatory ascidian…”
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2
Atractylodin Ameliorates Colitis via PPARα Agonism
Published in International journal of molecular sciences (02-01-2023)“…Atractylodin is a major compound in the rhizome of Atractylodes lancea, an oriental herbal medicine used for the treatment of gastrointestinal diseases,…”
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3
Viriditoxin Stabilizes Microtubule Polymers in SK-OV-3 Cells and Exhibits Antimitotic and Antimetastatic Potential
Published in Marine drugs (27-08-2020)“…Microtubules play a crucial role in mitosis and are attractive targets for cancer therapy. Recently, we isolated viriditoxin, a cytotoxic and antibacterial…”
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4
Anti-metastatic Effect of Natural Product-motivated Synthetic PPAR-γ Ligands
Published in Natural product sciences (2022)Get full text
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5
Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai
Published in Bioorganic & medicinal chemistry letters (01-05-2012)“…Four new cytochalasin derivatives (1–4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema…”
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6
Cyclooxygenase-2 Inhibitor Parecoxib Was Disclosed as a PPAR-γ Agonist by In Silico and In Vitro Assay
Published in Biomolecules & therapeutics (01-09-2021)“…In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for…”
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7
A New Cyclic Tetrapeptide from the Jellyfish-Derived Fungus Phoma sp
Published in Chemical & pharmaceutical bulletin (2012)“…A new cyclic tetrapeptide (1), along with known congeners (2, 3), was isolated from the fungus Phoma sp. derived from the giant jellyfish Nemopilema nomurai…”
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8
Antibacterial Polyketides from the Jellyfish-Derived Fungus Paecilomyces variotii
Published in Journal of natural products (Washington, D.C.) (26-08-2011)“…Four new polyketides (1–4) were isolated from the fungus Paecilomyces variotii, which was derived from the jellyfish Nemopilema nomurai. The planar structures…”
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9
A New Fungal Triterpene from the Fungus Aspergillus flavus Stimulates Glucose Uptake without Fat Accumulation
Published in Marine drugs (10-03-2022)“…Through activity-guided fractionation, a new triterpene (asperflagin, ) was isolated as a PPAR-γ agonist from the jellyfish-derived fungus . Asperflagin…”
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10
Neuroprotective Effect of Cyclo-(L-Pro-L-Phe) Isolated from the Jellyfish-Derived Fungus Aspergillus flavus
Published in Marine drugs (26-07-2021)“…Peroxisome proliferator-activated receptor (PPAR) expression has been implicated in pathological states such as cancer, inflammation, diabetes, and…”
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Peroxisome Proliferator Activated Receptor‐γ Agonistic Compounds from the Jellyfish‐Derived Fungus Cladosporium oxysporum
Published in Chemistry & biodiversity (01-09-2023)“…Abstract In our search for peroxisome proliferator‐activated receptor (PPAR) agonists, five undescribed compounds, namely two acyclic diterpenes ( 1 and 2 ;…”
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12
An Algal Metabolite-Based PPAR-γ Agonist Displayed Anti-Inflammatory Effect via Inhibition of the NF-κB Pathway
Published in Marine drugs (30-05-2019)“…In our previous study, a synthetic compound, (+)-( , )- , that incorporated the key structures of anti-inflammatory algal metabolites and the endogenous…”
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13
Midterm Clinical Outcomes of Endovascular Treatment for Acute Aortic Dissection with Malperfusion Syndrome
Published in Vascular specialist international (07-06-2024)“…Purpose: There is limited data on the midterm results of endovascular treatment for acute type B aortic dissection (TBAD) with malperfusion syndrome (MS),…”
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14
New glucosidated pyrazinoquinazoline indole alkaloids from fungus Aspergillus fumigatus derived of a jellyfish
Published in Tetrahedron (14-01-2015)“…Three new pyrazinoquinazoline indole glucosides (1–3) were isolated from the fungus Aspergillus fumigatus derived from the jellyfish Nemopilema nomurai…”
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15
An unusual 1(10→19)abeo steroid from a jellyfish-derived fungus
Published in Tetrahedron letters (22-06-2016)“…[Display omitted] •A new C25 abeo-sterol (phomarol) was isolated from a jellyfish-derived fungus.•Phomarol is unique with a 7-membered carbocyclic A ring…”
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16
Epimeric methylsulfinyladenosine derivatives from the marine ascidian Herdmania momus
Published in Bioorganic & medicinal chemistry letters (15-08-2013)“…Investigation of the secondary metabolites of the ascidian Herdmania momus led to the isolation and characterization of four new nucleoside derivatives (1–4)…”
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17
Gliotoxin is Antibacterial to Drug-resistant Piscine Pathogens
Published in Natural product sciences (2018)“…By activity-guided fractionation, gliotoxin was isolated as an antibacterial metabolite of the fungus Penicillium decumbens which was derived from the…”
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18
Synthesis of PPAR-γ activators inspired by the marine natural product, paecilocin A
Published in Marine drugs (13-02-2014)“…A series of N-substituted phthalimide derivatives were synthesized based on a pharmacophore study of paecilocin A (a natural PPAR-γ agonist) and synthetic…”
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19
Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists
Published in Bioorganic & medicinal chemistry (15-08-2012)“…On the basis of a marine fungal phthalide (paecilocin A) skeleton, we synthesized 20 analogs and evaluated them for peroxisome proliferator-activated receptor…”
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20
Viriditoxin, from a Jellyfish-derived Fungus, is Antibiotic to Fish Pathogens
Published in Natural product sciences (01-03-2013)“…A bioassay-guided fractionation of the extract of the fungus Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai, led to the…”
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