Search Results - "La Chica Lhoëst, Maria Teresa"
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Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia
Published in Journal of medicinal chemistry (11-05-2023)“…The accumulation of lipids in cardiomyocytes contributes to cardiac dysfunction. The specific blockage of cardiomyocyte cholesteryl ester (CE) loading by…”
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Journal Article -
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Peptides against Low Density Lipoprotein (LDL) Aggregation Inhibit Intracellular Cholesteryl Ester Loading and Proliferation of Pancreatic Tumor Cells
Published in Cancers (11-02-2022)“…Dyslipidemia, metabolic disorders and/or obesity are postulated as risk factors for pancreatic ductal adenocarcinoma (PDAC). The majority of patients with…”
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Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
Published in Metabolic engineering (01-05-2023)“…Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose…”
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Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response
Published in Biomedicine & pharmacotherapy (01-08-2022)“…Antibodies against the P3 sequence (Gly1127-Cys1140) of LRP1 (anti-P3 Abs) specifically block cholesteryl ester (CE) accumulation in vascular cells. LRP1 is a…”
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