Search Results - "La Cava, A."

Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease by Liu, SD, Lee, S, Cava, A La, Motran, CC, Hahn, BH, Miceli, MC

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a hyperactive immune system, including activation of autoreactive T and B…”
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Organ-specific features of natural killer cells by Shi, Fu-Dong, Ljunggren, Hans-Gustaf, La Cava, Antonio, Van Kaer, Luc

“…Key Points Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals in target organs of disease. However, the…”
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Reply to Choubey et al by Dniesh, R, Hahn, B H, La Cava, A, Singh, R P

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Distinct gene signature revealed in white blood cells, CD4 and CD8 T cells in (NZBx NZW) F1 lupus mice after tolerization with anti-DNA Ig peptide by Singh, R P, Dinesh, R, Elashoff, D, de Vos, S, Rooney, R J, Patel, D, La Cava, A, Hahn, B H

“…Tolerizing mice polygenically predisposed to lupus-like disease (NZB/NZW F1 females) with a peptide mimicking anti-DNA IgG sequences containing MHC class I and…”
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T-regulatory cells in systemic lupus erythematosus by La Cava, A

“…Thymus-derived CD4+CD25highFoxp3+ T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of…”
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Lupus and T Cells by La Cava, A

“…T-cell abnormalities and aberrant T helper cytokine profiles have been implicated in the loss of immune tolerance to nuclear and cytoplasmic antigens and…”
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Genetic deficiency of β2-containing nicotinic receptors attenuates brain injury in ischemic stroke by Liu, Q, Tang, Z, Gan, Y, Wu, W, Kousari, A, La Cava, A, Shi, F.-D

“…Highlights • Genetic deficiency of β2-nAChRs attenuates brain infarction and neurological deficit in ischemic stroke. • Pharmacological inhibition of β2-nAChRs…”
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Differential Effects of IL-21 during Initiation and Progression of Autoimmunity against Neuroantigen by Vollmer, Timothy L, Liu, Ruolan, Price, Mary, Rhodes, Susan, La Cava, Antonio, Shi, Fu-Dong

“…The cytokine IL-21 is closely related to IL-2 and IL-15, a cytokine family that uses the common gamma-chain for signaling. IL-21 is expressed by activated…”
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Erratum: Reply to Choubey et al by Dinesh, R, Hahn, B H, La Cava, A, Singh, R P

“…Correction to: Genes and Immunity (2011) 12, 496; doi:10.1038/gene.2011.48 Since the publication of this paper, the authors have noticed an error in the…”
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Interferon-inducible gene 202b controls CD8 T cell-mediated suppression in anti-DNA Ig peptide-treated (NZB × NZW) F1 lupus mice by Dinesh, R, Hahn, B H, La Cava, A, Singh, R P

“…Administration of an artificial peptide (pConsensus) based on anti-DNA IgG sequences that contain major histocompatibility complex class I and class II T-cell…”
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Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptin by Hahn, BH, Lourencço, EV, McMahon, M., Skaggs, B., Le, E., Anderson, M., Iikuni, N., Lai, CK, La Cava, A.

“…Atherosclerosis is accelerated in people with systemic lupus erythematosus, and the presence of dysfunctional, pro-inflammatory high-density lipoproteins is a…”
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IL-21 Modulates CD4⁺ CD25⁺ Regulatory T-Cell Homeostasis in Experimental Autoimmune Encephalomyelitis by Piao, W.-H, Jee, Y.H, Liu, R.L, Coons, S.W, Kala, M, Collins, M, Young, D.A, Campagnolo, D.I, Vollmer, T.L, Bai, X.-F, La Cava, A, Shi, F.-D

“…The homeostasis of CD4 ⁺ CD25 ⁺ regulatory T cells (Tregs) depends on the cytokine interleukin (IL)-2. As IL-21 shares sequence homology with IL-2 and the…”
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Leptin in autoimmunity: many questions, some answers by Matarese, G., Leiter, E. H., La Cava, A.

“…It has recently become apparent that several molecules involved in the control of metabolism also play an important function in the regulation of immune…”
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The Yin and Yang of CD4(+) regulatory T cells in autoimmunity and cancer by Galgani, M, Di Giacomo, A, Matarese, G, La Cava, A

“…The immune system balances effector responses with tolerance, to protect the host from pathogens while minimizing local damage to tissue. An altered control of…”
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Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia by Liu, R., La Cava, A., Bai, X.-F., Jee, Y., Price, M., Campagnolo, D. I., Christadoss, P., Vollmer, T. L., Van Kaer, L., Shi, F.-D.

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The weight of leptin in immunity by Cava, Antonio La, Matarese, Giuseppe

“…Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. As a hormone, leptin regulates food…”
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An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness by Procaccini, Claudio, De Rosa, Veronica, Galgani, Mario, Abanni, Luisa, Calì, Gaetano, Porcellini, Antonio, Carbone, Fortunata, Fontana, Silvia, Horvath, Tamas L., La Cava, Antonio, Matarese, Giuseppe

“…There is a discrepancy between the in vitro anergic state of CD4 +CD25 hiFoxP3 + regulatory T (Treg) cells and their in vivo proliferative capability. The…”
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IL-17 promotes murine lupus by Amarilyo, Gil, Lourenço, Elaine V, Shi, Fu-Dong, La Cava, Antonio

“…The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we…”
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Cellular and Molecular Mechanisms of Regulation of Autoantibody Production in Lupus by HAHN, BEVRA H., EBLING, FANNY, SINGH, RAM R., SINGH, RAM P., KARPOUZAS, GEORGE, LA CAVA, ANTONIO

“…: The hyperactive interaction between helper T cells and autoimmune B cells in individuals predisposed to systemic lupus erythematosus (SLE) can be interrupted…”
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Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses by Procaccini, Claudio, De Rosa, Veronica, Galgani, Mario, Carbone, Fortunata, Cassano, Silvana, Greco, Dario, Qian, Kui, Auvinen, Petri, Calì, Gaetano, Stallone, Giovanni, Formisano, Luigi, La Cava, Antonio, Matarese, Giuseppe

“…The sensing by T cells of metabolic and energetic changes in the microenvironment can determine the differentiation, maturation, and activation of these cells…”
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