Search Results - "Laßek, Melanie"

Amyloid precursor proteins are constituents of the presynaptic active zone by Laßek, Melanie, Weingarten, Jens, Einsfelder, Ulf, Brendel, Peter, Müller, Ulrike, Volknandt, Walter

“…The amyloid precursor protein (APP) and its mammalian homologs, APLP1, APLP2, have been allocated to an organellar pool residing in the Golgi apparatus and in…”
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The synaptic proteome by Laßek, Melanie, Weingarten, Jens, Volknandt, Walter

“…Synapses are focal hot spots for signal transduction and plasticity in the brain. A synapse comprises an axon terminus, the presynapse, the synaptic cleft…”
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The proteome of the presynaptic active zone from mouse brain by Weingarten, Jens, Laßek, Melanie, Mueller, Benjamin F., Rohmer, Marion, Lunger, Ilaria, Baeumlisberger, Dominic, Dudek, Simone, Gogesch, Patricia, Karas, Michael, Volknandt, Walter

“…Neurotransmitter release as well as the structural and functional dynamics of the presynaptic active zone is controlled by proteinaceous components. Here we…”
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APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone by Laßek, Melanie, Weingarten, Jens, Wegner, Martin, Mueller, Benjamin F, Rohmer, Marion, Baeumlisberger, Dominic, Arrey, Tabiwang N, Hick, Meike, Ackermann, Jörg, Acker-Palmer, Amparo, Koch, Ina, Müller, Ulrike, Karas, Michael, Volknandt, Walter

“…The hallmarks of Alzheimer's disease (AD) are characterized by cognitive decline and behavioral changes. The most prominent brain region affected by the…”
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Amyloid precursor protein knockout diminishes synaptic vesicle proteins at the presynaptic active zone in mouse brain by Laßek, Melanie, Weingarten, Jens, Acker-Palmer, Amparo, Bajjalieh, Sandra M, Muller, Ulrike, Volknandt, Walter

“…The amyloid precursor protein (APP) has previously been allocated to an organellar pool residing in the Golgi apparatus and in endosomal compartments, and in…”
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The Proteome of the Murine Presynaptic Active Zone by Laßek, Melanie, Weingarten, Jens, Volknandt, Walter

“…The proteome of the presynaptic active zone controls neurotransmitter release and the short- and long-term structural and functional dynamics of the nerve…”
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Regional Specializations of the PAZ Proteomes Derived from Mouse Hippocampus, Olfactory Bulb and Cerebellum by Weingarten, Jens, Laßek, Melanie, Mueller, Benjamin F, Rohmer, Marion, Baeumlisberger, Dominic, Beckert, Benedikt, Ade, Jens, Gogesch, Patricia, Acker-Palmer, Amparo, Karas, Michael, Volknandt, Walter

“…Neurotransmitter release as well as structural and functional dynamics at the presynaptic active zone (PAZ) comprising synaptic vesicles attached to the…”
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The Amyloid Precursor Protein-A Novel Player within the Molecular Array of Presynaptic Nanomachines by Laßek, Melanie, Weingarten, Jens, Wegner, Martin, Volknandt, Walter

“…More than 20 years ago the amyloid precursor protein (APP) was identified as the precursor protein of the Aβ peptide, the main component of senile plaques in…”
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APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones by Laßek, Melanie, Weingarten, Jens, Wegner, Martin, Neupärtl, Moritz, Array, Tabiwang N, Harde, Eva, Beckert, Benedikt, Golghalyani, Vahid, Ackermann, Jörg, Koch, Ina, Müller, Ulrike C, Karas, Michael, Acker-Palmer, Amparo, Volknandt, Walter

“…Synaptic release sites are characterized by exocytosis-competent synaptic vesicles tightly anchored to the presynaptic active zone (PAZ) whose proteome…”
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