Search Results - "LYTTLE, M. H"

Coaxial Stacking of Helixes Enhances Binding of Oligoribonucleotides and Improves Predictions of RNA Folding by Walter, Amy E., Turner, Douglas H., Kim, James, Lyttle, Matthew H., Müller, Peter, Mathews, David H., Zuker, Michael

“…An RNA model system consisting of an oligomer binding to a 4-nt overhang at the 5' end of a hairpin stem provides thermodynamic parameters for helix-helix…”
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Design, Synthesis, and Evaluation of Latent Alkylating Agents Activated by Glutathione S-Transferase by Satyam, Apparao, Hocker, Michael D, Kane-Maguire, Kim A, Morgan, Amy S, Villar, Hugo O, Lyttle, Matthew H

“…In search of compounds with improved specificity for targeting the important cancer-associated P1-1 glutathione S-transferase (GST) isozyme, new analogs 4 and…”
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Isozyme-specific glutathione-S-transferase inhibitors : design and synthesis by LYTTLE, M. H, HOCKER, M. D, HUI, H. C, CALDWELL, C. G, AARON, D. T, ENGQVIST-GOLDSTEIN, A, FLATGAARD, J. E, BAUER, K. E

“…Glutathione-S-transferase (GST) isozyme-selective inhibitors were designed by an empirically guided strategy. In the first phase, literature data were used to…”
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Glutathione-S-transferase Activates Novel Alkylating Agents by Lyttle, Matthew H, Satyam, Apparao, Hocker, Michael D, Bauer, Karin E, Caldwell, Colby G, Hui, Hon C, Morgan, Amy S, Mergia, Alemayehu, Kauvar, Lawrence M

“…Alkylating agents which are activated by glutathion-S-transferases (GSTs) have been designed and synthesized. The model compound…”
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A Tetramethyl Rhodamine (Tamra) Phosphoramidite Facilitates Solid-Phase-Supported Synthesis of 5‘-Tamra DNA by Lyttle, Matthew H, Carter, Timothy G, Dick, Daren J, Cook, Ronald M

“…5-Carboxy Tamra 1 was conjugated to 4-hydroxypiperidine with BOP and N-methylmorpholine, and the resulting 5-(N-pipyridyl-4-hydroxy)-Tamra carboxamide 2 was…”
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A New Universal Linker for Solid Phase DNA Synthesis by Lyttle, Matthew H., Hudson, Derek, Cook, Ronald M.

“…A method is described as an alternative to the use of nucleoside pre-functionalized supports for DNA synthesis. The procedure should allow the generation of…”
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Mutagenesis using trinucleotide beta-cyanoethyl phosphoramidites by Lyttle, M H, Napolitano, E W, Calio, B L, Kauvar, L M

“…There is no easy way to selectively introduce mixtures of codon triplets into mutagenesis libraries. Solid-phase-supported DNA synthesis using successive…”
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Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors by Ciaccio, P J, Shen, H, Jaiswal, A K, Lyttle, M H, Tew, K D

“…We investigated the effects of glutathione-S-transferase (GST) inhibitor treatment on human colon HT29 cell mRNA levels of dihydrodiol dehydrogenase (DDH),…”
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RNA hairpin loop stability depends on closing base pair by Serra, Martin J., Lyttle, Matthew H., Axenson, Theresa J., Schadt, Calvin A., Turner, Douglas H.

“…Thermodynamic parameters are reported for hairpin formation in 1 M NaCl by RNA sequences of the type GGXAUAAUAYCC. where X and Y are CG, GC, AU, UA, GU, or UG…”
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Enzymatic and NMR analysis of oligoribonucleotides synthesized with 2'-tert-butyldimethylsilyl protected cyanoethylphosphoramidite monomers by YU YING WANG, LYTTLE, M. H, BORER, P. N

“…The regioisomeric integrity of the internucleotide phosphate linkage in synthetic RNA using 2'-tert-butyldimethylsilyl protection was examined using enzymatic…”
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Site-specific incorporation of nonnatural residues during in vitro protein biosynthesis with semisynthetic aminoacyl-tRNAs by BAIN, J. D, DIALA, E. S, GLABE, C. G, WACKER, D. A, LYTTLE, M. H, DIX, T. A, CHAMBERLIN, A. R

“…A method is presented for the incorporation of nonnatural amino acids into proteins during in vitro cell-free translation. A combination of chemical synthesis…”
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3'-modified oligonucleotides and their conjugates by Lyttle, M H

“…Solid-phase synthesis of 3'-aminoalkyl, 3'-thioalkyl, and 3'-polyethyleneglycol are described. The first two are important as specific points of attachment for…”
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Evaluation of New Linkers and Synthetic Methods for Internal Modified Oligonucleotides by Walton, Troy A., Lyttle, Matthew H., Dick, Daren J., Cook, Ronald M.

“…Several fluorescence resonance energy transfer (FRET) oligonucleotide probes were made with different internal linkages between the DNA and the quencher dye…”
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New Reagents and Methods for the Synthesis of Internal and 3‘-Labeled DNA by Lyttle, Matthew H., Walton, Troy A., Dick, Daren J., Carter, Timothy G., Beckman, Jacob H., Cook, Ronald M.

“…The syntheses of two new nucleoside phosphoramidites containing a hydroxyl functionality masked by a levulinate protecting group are presented; N…”
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Versatile Linker Chemistry for Synthesis of 3‘-Modified DNA by Lyttle, Matthew H, Adams, Howard, Hudson, Derek, Cook, Ronald M

“…A general method is described for the solid phase supported synthesis of DNA containing 3‘-terminal phosphodiesters modified with linkers bearing either amino,…”
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p-Nitrobenzyl side-chain protection for solid-phase synthesis by Hocker, M D, Caldwell, C G, Macsata, R W, Lyttle, M H

“…A solid-phase supported peptide synthesis (SPPS) strategy using p-nitrobenzyl (pNB) esters, thioethers and carbamates for side-chain protection is described…”
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Salt-induced immobilizations of DNA oligonucleotides on an epoxide-activated high-performance liquid Chromatographic affinity support by Wheatley, Jeffrey B., Lyttle, Mathew H., Hocker, Michael D., Schmidt, Donald E.

“…Synthetic oligonucleotides, possessing a recognition sequence for the transcription factor NF-κB, were immobilized onto an epoxide-activated…”
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New nucleoside phosphoramidites and coupling protocols for solid-phase RNA synthesis by Lyttle, Matthew H, Wright, Peter B, Sinha, Nanda D, Bain, J. D, Chamberlin, A. Richard

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Construction of affinity sorbents utilizing glutathione analogs by Lyttle, M H, Aaron, D T, Hocker, M D, Hughes, B R

“…Solution-phase N-fluorenylmethoxycarbonyl (Fmoc) mediated peptide synthesis has been adapted to the synthesis of glutathione (gamma-glutamyl-cysteinyl-glycine)…”
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1,5-Disubstituted cyclooctatetraenes by Lyttle, Matthew H, Streitwieser, Andrew, Miller, Michael J

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