Search Results - "LYONS, S. D"

To treat or not to treat? An evidence-based practice guide for the management of endometrial polyps by Sheng, K. K., Lyons, S. D.

“…Endometrial polyps are a common finding, with a prevalence of about 40%, and are usually diagnosed incidentally as most are asymptomatic. Symptomatic polyps…”
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Ligand-specific oligomerization of T-cell receptor molecules by Davis, Mark M, Reich, Ziv, Boniface, J. Jay, Lyons, Daniel S, Borochov, Nina, Wachtel, Ellen J

“…T cells initiate many immune responses through the interaction of their T-cell antigen receptors (TCR) with antigenic peptides bound to major…”
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Kinetic Discrimination in T-Cell Activation by Rabinowitz, Joshua D., Beeson, Craig, Lyons, Daniel S., Davis, Mark M., McConnell, Harden M.

“…We propose a quantitative model for T-cell activation in which the rate of dissociation of ligand from T-cell receptors determines the agonist and antagonist…”
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Improvement in pelvic pain with botulinum toxin type A – Single vs. repeat injections by Nesbitt-Hawes, E.M., Won, H., Jarvis, S.K., Lyons, S.D., Vancaillie, T.G., Abbott, J.A.

“…The aim of this prospective study was to report the outcomes of pain and vaginal pressures of successive botulinum toxin type A injections for women with…”
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Two-step binding mechanism for T-cell receptor recognition of peptide-MHC by Davis, Mark M, Wu, Lawren C, Tuot, Delphine S, Lyons, Daniel S, Garcia, K. Christopher

“…T cells probe a diverse milieu of peptides presented by molecules of the major histocompatibility complex (MHC) by using the T-cell receptor (TCR) to scan…”
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Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells by SANT, M. E, LYONS, S. D, PHILLIPS, L, CHRISTOPHERSON, R. I

“…The pathway for de novo biosynthesis of purine nucleotides contains two one-carbon transfer reactions catalyzed by glycinamide ribotide (GAR) and…”
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Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia by LYONS, S. D, SANT, M. E, CHRISTOPHERSON, R. I

“…The glutamine antagonists, acivicin (NSC 163501), azaserine (NSC 742), and 6-diazo-5-oxo-L-norleucine (DON) (NSC 7365), are potent inhibitors of many…”
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Thermodynamics of T Cell Receptor Binding to Peptide-MHC: Evidence for a General Mechanism of Molecular Scanning by Boniface, J J, Reich, Z, Lyons, D S, Davis, M M

“…Antigen-dependent activation of T lymphocytes requires T cell receptor (TCR)-mediated recognition of specific peptides, together with the MHC molecules to…”
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A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists by Lyons, Daniel S, Lieberman, Stephanie A, Hampl, Johannes, Boniface, J.Jay, Chien, Yueh-hsiu, Berg, Leslie J, Davis, Mark M

“…T lymphocyte activation is mediated by the interaction of specific TCR with antigenic peptides bound to MHC molecules. Single amino acid substitutions are…”
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Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells by Kemp, A J, Lyons, S D, Christopherson, R I

“…Acivicin (NSC 163501) and dichloroallyl lawsone (NSC 126771) are potent inhibitors of nucleotide biosynthesis with consequent anti-cancer activity against…”
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Cytotoxic effects of dihydroorotase inhibitors upon human CCRF-CEM leukemia by BROOKE, J, SZABADOS, E, LYONS, S. D, GOODRIDGE, R. J, HARSANYI, M. C, POINER, A, CHRISTOPHERSON, R. I

“…6-L-Thiodihydroorotate (TDHO) and 2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylate (HDDP) are potent inhibitors of mammalian dihydroorotase in vitro (R. I…”
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Comparison of 1% sodium tetradecyl sulfate to a thrombogenic sclerosant cocktail for endoscopic sclerotherapy by Lyons, S D, Sugawa, C, Geller, E R, Vandenberg, D M

“…This preliminary report suggests superior efficacy of a mixture of Sodium Tetradecyl Sulfate, thrombin and cefazolin (ST-Thr-Cef) over 1% Sodium Tetradecyl…”
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Re: Tripathi AK, Mee SN, Martin DL, Katsarma E. The ‘transverse intraosseous loop technique’ (TILT) to re-insert flexor tendons in zone 1. J Hand Surg Eur. 2009, 34: 85-9 by Lyons, I.D.S., Iwuagwu, F. C.

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Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia by SANT, M. E, LYONS, S. D, KEMP, A. J, MCCLURE, L. K, SZABADOS, E, CHRISTOPHERSON, R. I

“…Pyrazofurin (NSC 143095) as the monophosphate derivative is a potent inhibitor of orotidine 5'-monophosphate (OMP) decarboxylase of the pyrimidine pathway and…”
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Chromatographic analysis of purine precursors in mouse L1210 leukemia by Sant, M E, Poiner, A, Harsanyi, M C, Lyons, S D, Christopherson, R I

“…A number of antagonists of nucleotide metabolism with anti-cancer activity affect the de novo purine pathway. To determine the biochemical mechanisms of…”
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Cytotoxic Effects of Inhibitors of de Novo Pyrimidine Biosynthesis upon Plasmodium falciparum by Seymour, Kristen K, Lyons, Stephen D, Phillips, Leonidas, Rieckmann, Karl H, Christopherson, Richard I

“…The malarial parasite Plasmodium falciparum can only synthesize pyrimidine nucleotides via the de novo pathway which is therefore a suitable target for…”
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Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced by Boniface, J J, Lyons, D S, Wettstein, D A, Allbritton, N L, Davis, M M

“…Many class II histocompatibility complex molecules bind antigenic peptides optimally at low pH, consistent with their exposure to antigen in acidic endosomal…”
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Stability of Empty and Peptide-Loaded Class II Major Histocompatibility Complex Molecules at Neutral and Endosomal pH: Comparison to Class I Proteins by Reich, Ziv, Altman, John D., Boniface, J. Jay, Lyons, Daniel S., Kozono, Haruo, Ogg, Graham, Morgan, Chantal, Davis, Mark M.

“…The structure and thermal stability of empty and peptide-filled forms of the murine class II major histocompatibility complex (MHC) molecule I-Ekwere studied…”
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Phe-46(CD4) orients the distal histidine for hydrogen bonding to bound ligands in sperm whale myoglobin by Lai, H H, Li, T, Lyons, D S, Phillips, Jr, G N, Olson, J S, Gibson, Q H

“…The role of Phe-46(CD4) in modulating the functional properties of sperm whale myoglobin was investigated by replacing this residue with Leu, Ile, Val, Ala,…”
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Metabolic effects of thiopurine derivatives against human CCRF-CEM leukaemia cells by Shi, Run Zhang, Lyons, Stephen D., Christopherson, Richard I.

“…Background and aims. To compare the metabolic effects induced by the anticancer drugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and 6-methylmercaptopurine…”
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