Search Results - "LYNCH, Gary"

Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease by Lauterborn, Julie C., Scaduto, Pietro, Cox, Conor D., Schulmann, Anton, Lynch, Gary, Gall, Christine M., Keene, C. Dirk, Limon, Agenor

“…Synaptic disturbances in excitatory to inhibitory (E/I) balance in forebrain circuits are thought to contribute to the progression of Alzheimer’s disease (AD)…”
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A resource‐based perspective on the regulatory welfare state: Social security in the United Kingdom by Horton, David P., Lynch‐Wood, Gary

“…The article provides a resource‐based perspective on the polymorphic regulatory welfare state. It shows regulatory and fiscal tools applied in the UK social…”
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AMPA receptor-induced local brain-derived neurotrophic factor signaling mediates motor recovery after stroke by Clarkson, Andrew N, Overman, Justine J, Zhong, Sheng, Mueller, Rudolf, Lynch, Gary, Carmichael, S Thomas

“…Stroke is the leading cause of adult disability. Recovery after stroke shares similar molecular and cellular properties with learning and memory. A main…”
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Glial Biology in Learning and Cognition by Fields, R. Douglas, Araque, Alfonso, Johansen-Berg, Heidi, Lim, Soo-Siang, Lynch, Gary, Nave, Klaus-Armin, Nedergaard, Maiken, Perez, Ray, Sejnowski, Terrence, Wake, Hiroaki

“…Neurons are exquisitely specialized for rapid electrical transmission of signals, but some properties of glial cells, which do not communicate with electrical…”
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Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors by Ivy, Autumn S, Rex, Christopher S, Chen, Yuncai, Dubé, Céline, Maras, Pamela M, Grigoriadis, Dimitri E, Gall, Christine M, Lynch, Gary, Baram, Tallie Z

“…Chronic stress impairs learning and memory in humans and rodents and disrupts long-term potentiation (LTP) in animal models. These effects are associated with…”
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Hippocampal Focal Knockout of CBP Affects Specific Histone Modifications, Long-Term Potentiation, and Long-Term Memory by BARRETT, Ruth M, MALVAEZ, Melissa, KRAMAR, Eniko, MATHEOS, Dina P, ARRIZON, Abraham, CABRERA, Sara M, LYNCH, Gary, GREENE, Robert W, WOOD, Marcelo A

“…To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in neurons of the CA1 region of the hippocampus during memory formation,…”
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Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents by Le, Aliza A., Quintanilla, Julian, Amani, Mohammad, Piomelli, Daniele, Lynch, Gary, Gall, Christine M.

“…There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little is known about effects of early…”
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Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling by Chen, Yuncai, Rex, Christopher S., Rice, Courtney J., Dubé, Céline M., Gall, Christine M., Lynch, Gary, Baram, Tallie Z., McEwen, Bruce S.

“…Stress affects the hippocampus, a brain region crucial for memory. In rodents, acute stress may reduce density of dendritic spines, the location of…”
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Synaptic evidence for the efficacy of spaced learning by Kramár, Enikö A., Babayan, Alex H., Gavin, Cristin F., Cox, Conor D., Jafari, Matiar, Gall, Christine M., Rumbaugh, Gavin, Lynch, Gary

“…The superiority of spaced vs. massed training is a fundamental feature of learning. Here, we describe unanticipated timing rules for the production of…”
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The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory by Vogel-Ciernia, Annie, Matheos, Dina P, Barrett, Ruth M, Kramár, Enikö A, Azzawi, Soraya, Chen, Yuncai, Magnan, Christophe N, Zeller, Michael, Sylvain, Angelina, Haettig, Jakob, Jia, Yousheng, Tran, Anthony, Dang, Richard, Post, Rebecca J, Chabrier, Meredith, Babayan, Alex H, Wu, Jiang I, Crabtree, Gerald R, Baldi, Pierre, Baram, Tallie Z, Lynch, Gary, Wood, Marcelo A

“…BAF53b is a neuron-specific component of the nucleosome remodeling complex mSWI/SNF that allows euchromatin formation and provides epigenetic regulation of…”
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Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation by Rex, Christopher S, Chen, Lulu Y, Sharma, Anupam, Liu, Jihua, Babayan, Alex H, Gall, Christine M, Lynch, Gary

“…The releasable factor adenosine blocks the formation of long-term potentiation (LTP). These experiments used this observation to uncover the synaptic processes…”
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Cytoskeletal Changes Underlie Estrogen's Acute Effects on Synaptic Transmission and Plasticity by Kramar, Eniko A, Chen, Lulu Y, Brandon, Nicholas J, Rex, Christopher S, Liu, Feng, Gall, Christine M, Lynch, Gary

“…Estrogen, in addition to its genomic effects in brain, causes rapid and reversible changes to synaptic operations. We report here that these acute actions are…”
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Determination of the Protein and Amino Acid Content of Fruit, Vegetables and Starchy Roots for Use in Inherited Metabolic Disorders by Boyle, Fiona, Lynch, Gary, Reynolds, Clare M, Green, Adam, Parr, Gemma, Howard, Caoimhe, Knerr, Ina, Rice, Jane

“…Amino acid (AA)-related inherited metabolic disorders (IMDs) and urea cycle disorders (UCDs) require strict dietary management including foods low in protein…”
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Changes in Synaptic Morphology Accompany Actin Signaling during LTP by Chen, Lulu Y, Rex, Christopher S, Casale, Malcolm S, Gall, Christine M, Lynch, Gary

“…Stabilization of long-term potentiation (LTP) is commonly proposed to involve changes in synaptic morphology and reorganization of the spine cytoskeleton. Here…”
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Modulation of the faecal microbiome of healthy adult dogs by inclusion of potato fibre in the diet by Panasevich, Matthew R., Kerr, Katherine R., Dilger, Ryan N., Fahey, George C., Guérin-Deremaux, Laetitia, Lynch, Gary L., Wils, Daniel, Suchodolski, Jan S., Steer, Jörg M, Dowd, Scot E., Swanson, Kelly S.

“…Inclusion of fermentable fibres in the diet can have an impact on the hindgut microbiome and provide numerous health benefits to the host. Potato fibre (PF), a…”
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Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice by Simmons, Danielle A, Rex, Christopher S, Palmer, Linda, Pandyarajan, Vijay, Fedulov, Vadim, Gall, Christine M, Lynch, Gary

“…Cognitive problems occur in asymptomatic gene carriers of Huntington's disease (HD), and mouse models of the disease exhibit impaired learning and substantial…”
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Technocracy, the market and the governance of England's National Health Service by Horton, David P., Lynch‐Wood, Gary

“…England's National Health Service, the fifth largest employer in the world, has become heavily influenced by expert authority and the market economy, which has…”
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Reduced Cognition in Syngap1 Mutants Is Caused by Isolated Damage within Developing Forebrain Excitatory Neurons by Ozkan, Emin D., Creson, Thomas K., Kramár, Enikö A., Rojas, Camilo, Seese, Ron R., Babyan, Alex H., Shi, Yulin, Lucero, Rocco, Xu, Xiangmin, Noebels, Jeffrey L., Miller, Courtney A., Lynch, Gary, Rumbaugh, Gavin

“…Syngap1 haploinsufficiency is a common cause of sporadic intellectual disability. Syngap1 mutations disrupt developing pyramidal neurons, although it remains…”
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A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability by Seese, Ronald R., Le, Aliza A., Wang, Kathleen, Cox, Conor D., Lynch, Gary, Gall, Christine M.

“…Fragile X syndrome (FXS) is associated with deficits in various types of learning, including those that require the hippocampus. Relatedly, hippocampal…”
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Sex differences in the context dependency of episodic memory by Le, Aliza A, Palmer, Linda C, Chavez, Jasmine, Gall, Christine M, Lynch, Gary

“…Context contributes to multiple aspects of human episodic memory including segmentation and retrieval. The present studies tested if, in adult male and female…”
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