Search Results - "LYKO, Frank"

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation by Lyko, Frank

“…Key Points The DNA methyltransferases (DNMTs) are a conserved family of cytosine methylases with a key role in epigenetic regulation. DNMT activity is highly…”
Get full text

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine by Stresemann, Carlo, Lyko, Frank

“…The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine (decitabine) are the currently most advanced drugs for epigenetic cancer…”
Get full text

The importance of non-histone protein methylation in cancer therapy by Rodríguez-Paredes, Manuel, Lyko, Frank

“…Epigenetic regulatory enzymes are generally considered innovative targets for cancer therapy and several histone methyltransferase inhibitors are currently…”
Get full text

Limited antibody specificity compromises epitranscriptomic analyses by Helm, Mark, Lyko, Frank, Motorin, Yuri

“…A controversial discussion on the occurrence of the RNA modification m 1 A in mRNA takes a new turn, as an antibody with a central role in modification mapping…”
Get full text

5-methylcytosine in RNA: detection, enzymatic formation and biological functions by Motorin, Yuri, Lyko, Frank, Helm, Mark

“…The nucleobase modification 5-methylcytosine (m⁵C) is widespread both in DNA and different cellular RNAs. The functions and enzymatic mechanisms of DNA…”
Get full text

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs by Legrand, Carine, Tuorto, Francesca, Hartmann, Mark, Liebers, Reinhard, Jacob, Dominik, Helm, Mark, Lyko, Frank

“…Cytosine-5 RNA methylation plays an important role in several biologically and pathologically relevant processes. However, owing to methodological limitations,…”
Get full text

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage by Schaefer, Matthias, Pollex, Tim, Hanna, Katharina, Tuorto, Francesca, Meusburger, Madeleine, Helm, Mark, Lyko, Frank

“…Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme family, but their substrate specificity and biological functions have been a…”
Get full text

Genome recoding by tRNA modifications by Tuorto, Francesca, Lyko, Frank

“…RNA modifications are emerging as an additional regulatory layer on top of the primary RNA sequence. These modifications are particularly enriched in tRNAs…”
Get full text

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis by Tuorto, Francesca, Liebers, Reinhard, Musch, Tanja, Schaefer, Matthias, Hofmann, Sarah, Kellner, Stefanie, Frye, Michaela, Helm, Mark, Stoecklin, Georg, Lyko, Frank

“…Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2…”
Get full text

Epigenetic regulation by heritable RNA by Liebers, Reinhard, Rassoulzadegan, Minoo, Lyko, Frank

“…Genomic concepts are based on the assumption that phenotypes arise from the expression of genetic variants. However, the presence of non-Mendelian inheritance…”
Get full text

DNA Methyltransferase Inhibitors and the Development of Epigenetic Cancer Therapies by Lyko, Frank, Brown, Robert

“…Epimutations, such as the hypermethylation and epigenetic silencing of tumor suppressor genes, play a role in the etiology of human cancers. In contrast to DNA…”
Get full text

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs by Zhang, Yunfang, Zhang, Xudong, Shi, Junchao, Tuorto, Francesca, Li, Xin, Liu, Yusheng, Liebers, Reinhard, Zhang, Liwen, Qu, Yongcun, Qian, Jingjing, Pahima, Maya, Liu, Ying, Yan, Menghong, Cao, Zhonghong, Lei, Xiaohua, Cao, Yujing, Peng, Hongying, Liu, Shichao, Wang, Yue, Zheng, Huili, Woolsey, Rebekah, Quilici, David, Zhai, Qiwei, Li, Lei, Zhou, Tong, Yan, Wei, Lyko, Frank, Zhang, Ying, Zhou, Qi, Duan, Enkui, Chen, Qi

“…The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has opened the possibility that sperm may function by delivering additional…”
Get full text

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines by SCHAEFER, Matthias, HAGEMANN, Sabine, HANNA, Katharina, LYKO, Frank

“…The cytosine analogues azacytidine and decitabine are currently being developed as drugs for epigenetic cancer therapy. Although various studies have shown…”
Get full text

Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines by Hagemann, Sabine, Heil, Oliver, Lyko, Frank, Brueckner, Bodo

“…The DNA methyltransferase inhibitors azacytidine and decitabine represent archetypal drugs for epigenetic cancer therapy. To characterize the demethylating…”
Get full text

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming by Solé-Boldo, Llorenç, Raddatz, Günter, Schütz, Sabrina, Mallm, Jan-Philipp, Rippe, Karsten, Lonsdorf, Anke S., Rodríguez-Paredes, Manuel, Lyko, Frank

“…Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has…”
Get full text

Methylation of Human MicroRNA Genes in Normal and Neoplastic Cells by Weber, Barbara, Stresemann, Carlo, Brueckner, Bodo, Lyko, Frank

“…MicroRNAs (miRNAs) are small RNA molecules that control gene expression by inhibition of protein translation or by degradation of cognate target mRNAs. Even…”
Get full text

Epigenetic cancer therapy: Proof of concept and remaining challenges by Mund, Cora, Lyko, Frank

“…Over the past few years several drugs that target epigenetic modifications have shown clinical benefits, thus seemingly validating epigenetic cancer therapy…”
Get full text

Time-resolved, integrated analysis of clonally evolving genomes by Legrand, Carine, Andriantsoa, Ranja, Lichter, Peter, Raddatz, Günter, Lyko, Frank

“…Clonal genome evolution is a key feature of asexually reproducing species and human cancer development. While many studies have described the landscapes of…”
Get full text

RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2 by Kiani, Jafar, Grandjean, Valérie, Liebers, Reinhard, Tuorto, Francesca, Ghanbarian, Hossein, Lyko, Frank, Cuzin, François, Rassoulzadegan, Minoo

“…RNA-mediated transmission of phenotypes is an important way to explain non-Mendelian heredity. We have previously shown that small non-coding RNAs can induce…”
Get full text

Clonal genome evolution and rapid invasive spread of the marbled crayfish by Gutekunst, Julian, Andriantsoa, Ranja, Falckenhayn, Cassandra, Hanna, Katharina, Stein, Wolfgang, Rasamy, Jeanne, Lyko, Frank

“…The marbled crayfish Procambarus virginalis is a unique freshwater crayfish characterized by very recent speciation and parthenogenetic reproduction. Marbled…”
Get full text