Search Results - "LYDYARD, P. M."

Role of B-cell antigen receptor-associated molecules and lipid rafts in CD5-induced apoptosis of B CLL cells by RENAUDINEAU, Y, NEDELLEC, S, BERTHOU, C, LYDYARD, P. M, YOUINOU, P, PERS, J-O

“…A total of 40 patients with B-CLL were investigated for CD5-triggered apoptosis and categorized as 20 resistant (group I) and 20 sensitive patients (group II)…”
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Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B‐chronic lymphocytic leukaemia (B‐CLL) by Porakishvili, N., Roschupkina, T., Kalber, T., Jewell, A. P., Patterson, K., Yong, K., Lydyard, P. M.

“…Abnormal CD4/CD8 ratios and T‐cell function have previously been shown in patients with B‐chronic lymphocytic leukaemia (B‐CLL). We have demonstrated that CD4+…”
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The effect of interleukin‐10 and of interleukin‐12 on the in vitro production of anti‐double‐stranded DNA antibodies from patients with systemic lupus erythematosus by Tyrrell‐Price, J., Lydyard, P M., Isenberg, D A.

“…IL‐10 and IL‐12 are cytokines which are important in regulating immune responses. Plasma levels of IL‐10 and autoantibodies against double‐stranded DNA (dsDNA)…”
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CD5-induced apoptosis of B cells in some patients with chronic lymphocytic leukemia by PERS, J. O, BERTHOU, C, PORAKISHVILI, N, BURDJANADZE, M, LE CALVEZ, G, ABGRALL, J. F, LYDYARD, P. M, YOUINOU, P, JAMIN, C

“…Although B chronic lymphocytic leukemia (B-CLL) is characterized by prolonged survival of CD5(+) B cells in vivo, these cells apoptose spontaneously in vitro…”
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Recent Progress in the Understanding of B‐Cell Functions in Autoimmunity by Porakishvili, N., Mageed, R., Jamin, C., Pers, J.‐O., Kulikova, N., Renaudineau, Y., Lydyard, P. M., Youinou, P.

“…Our early concepts of the normal role of B cells in immunity focused on their ability to produce antibodies (Ab) and in the case of autoimmune diseases…”
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Differential expression of CD180 and IgM by B‐cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes by Porakishvili, N., Kulikova, N., Jewell, A. P., Youinou, P. Y., Yong, K., Nathwani, A., Heelan, B., Duke, V., Hamblin, T. J., Wallace, P., Ely, P., Clark, E. A., Lydyard, P. M.

“…Summary We have studied the surface expression of the Toll‐like receptor family member CD180 on cells from 78 patients with B‐chronic lymphocytic leukaemia…”
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Age-related changes in human blood lymphocyte subpopulations by Erkeller-Yuksel, F M, Deneys, V, Yuksel, B, Hannet, I, Hulstaert, F, Hamilton, C, Mackinnon, H, Stokes, L T, Munhyeshuli, V, Vanlangendonck, F

“…Flow cytometric analysis of major lymphocyte populations and their subsets reveals age-related changes in the cellular human immune system. Immunophenotypic…”
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CD5/ B cells in nonorgan-specific autoimmune diseases: a fresh look by Youinou, P, Lydyard, P M

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Antibodies to mannose binding lectin in patients with systemic lupus erythematosus by Mok, M Y, Jack, D L, Lau, C S, Fong, D YT, Turner, M W, Isenberg, D A, Lydyard, P M

“…Deficiency of mannose binding lectin (MBL), a C-type lectin with structural similarities to C1q, has been shown to predispose to the development of systemic…”
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T cell receptor usage in patients with non‐progressing HIV infection by BODMAN‐SMITH, M. D., WILLIAMS, I., JOHNSTONE, R., BOYLSTON, A., LYDYARD, P. M., ZUMLA, A.

“…SUMMARY It is still unclear why some patients with HIV progress more slowly than others to developing full blown AIDS. In this study using flow cytometry we…”
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Human monoclonal anti‐phospholipid antibodies selectively bind to membrane phospholipid and β2‐glycoprotein I (β2‐GPI) on apoptotic cells by Pittoni, V., Ravirajan, C. T., Donohoe, S., Machin, S. J., Lydyard, P. M., Isenberg, D. A.

“…The ability of an anti‐phospholipid (LJ1) and an anti‐β2‐GPI (RSP‐57) human MoAb to bind to apoptotic but not viable cells was demonstrated in this study. Both…”
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Interferon-alpha up-regulates bcl-2 expression and protects B-CLL cells from apoptosis in vitro and in vivo by Jewell, A P, Worman, C P, Lydyard, P M, Yong, K L, Giles, F J, Goldstone, A H

“…The bcl-2 oncoprotein, which is involved in the t(14,18) translocation, protects cells against apoptosis. We examined the effects of interferon-alpha…”
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B cells underpin lupus immunopathology by Youinou, P, Lydyard, P M, Mageed, R A

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Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis by Tsoulfa, G, Rook, G A, Van-Embden, J D, Young, D B, Mehlert, A, Isenberg, D A, Hay, F C, Lydyard, P M

“…Autoantigens cross reactive with mycobacteria are implicated in the pathogenesis of adjuvant arthritis in the rat, and there are reports of changes in the…”
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Lack of NK cells in lupus patients with renal involvement by Erkeller-Yuksel, F M, Lydyard, P M, Isenberg, D A

“…We have previously shown that patients with SLE have significantly lower percentages and absolute numbers of NK(CD3-/CD16+56) cells in their peripheral blood…”
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Rheumatoid arthritis: how well do the theories fit the evidence? by McCULLOCH, J., LYDYARD, P. M., ROOK, G. A. W.

“…SUMMARY In this brief review, inspired partly by a symposium at the autumn meeting of the British Society for Immunology, 1992, varying hypotheses concerning…”
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Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies by OLIVEIRA, G. G. S., HUTCHINGS, P. R., ROITT, I. M., LYDYARD, P. M.

“…SUMMARY NZB mice spontaneously develop haemolytic anaemia as the result of production of erythrocyte autoantibodies. The mechanisms leading to breakdown in…”
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Differential expression of Fc receptors for IgG by monocytes and granulocytes from neonates and adults by MAEDA, M., VAN SCHIE, R. C. A. A., YÜKSEL, B., GREENOUGH, A., FANGER, M. W., GUYRE, P. M., LYDYARD, P. M.

“…The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fc moiety of IgG (FcγR) are important in…”
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Diverse antigen specificity of erythrocyte‐reactive monoclonal autoantibodies from NZB mice by DESÁ OLIVEIRA, G. G., IZUI, S., RAVIRAJAN, C. T., MAGEED, R. A. K., LYDYARD, P. M., ELSON, C. J., BARKER, R. N.

“…The specificities of a panel of erythrocyte‐reactive MoAbs derived from NZB mice with autoimmune haemolytic anaemia (AIHA) were determined by…”
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The antibody repertoire of early human B cells. I. High frequency of autoreactivity and polyreactivity by Lydyard, P M, Quartey-Papafio, R, Bröker, B, Mackenzie, L, Jouquan, J, Blaschek, M A, Steele, J, Petrou, M, Collins, P, Isenberg, D

“…Cord blood and fetal liver B cells were immortalized using Epstein-Barr virus, and IgM antibodies from the resulting lines and clones were examined for their…”
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