Search Results - "LUTHER, ROBERT R"

Intrathecal Ziconotide in the Treatment of Refractory Pain in Patients With Cancer or AIDS: A Randomized Controlled Trial by Staats, Peter S, Yearwood, Thomas, Charapata, Steven G, Presley, Robert W, Wallace, Mark S, Byas-Smith, Michael, Fisher, Robert, Bryce, David A, Mangieri, Eugene A, Luther, Robert R, Mayo, Martha, McGuire, Dawn, Ellis, David

“…CONTEXT Ziconotide (formerly SNX-111) selectively blocks N-type voltage-sensitive calcium channels and may be effective in patients with pain that is…”
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Use of Intrathecal SNX-111, a Novel, N-Type, Voltage-Sensitive, Calcium Channel Blocker, in the Management of Intractable Brachial Plexus Avulsion Pain by Brose, William G, Gutlove, David P, Luther, Robert R, Bowersox, S Scott, McGuire, Dawn

“…OBJECTIVE:The objective was to assess the analgesic, antihyperesthesic, and antiallodynic properties of SNX-111 in neuropathic pain. DESIGN:We describe a…”
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The effects of fenoldopam, a selective dopamine receptor agonist, on systemic and renal hemodynamics in normotensive subjects by Mathur, Vandana S, Swan, Suzanne K, Lambrecht, Lawrence J, Anjum, Shakeel, Fellmann, Jere, McGuire, Dawn, Epstein, Murray, Luther, Robert R

“…OBJECTIVE:Acute renal failure, frequently a consequence of renal vasoconstriction and subsequent renal ischemia, is a common problem for which no proven…”
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Fenoldopam: a new parenteral antihypertensive: Consensus roundtable on the management of perioperative hypertension and hypertensive crises by Oparil, Suzanne, Aronson, Solomon, Deeb, G.Michael, Epstein, Murray, Levy, Jerrold H, Luther, Robert R, Prielipp, Richard, Taylor, Addison

“…A panel of clinicians from anesthesiology, surgery, nephrology, hypertension, cardiology, and pharmacology was convened to discuss pharmacologic therapeutics…”
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Sympatholysis After Neuron-Specific, N-Type, Voltage-Sensitive Calcium Channel Blockade: First Demonstration of N-Channel Function in Humans by McGuire, Dawn, Bowersox, Scott, Fellmann, Jere D, Luther, Robert R

“…SNX-111 is the first neuronal N-type, voltagesensitive calcium channel (VSCC) blocker to enter clinical drug development. Areas of potential therapeutic…”
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Prolonged fenoldopam infusions in patients with mild to moderate hypertension: Pharmacodynamic and pharmacokinetic effects by Taylor, Addison A, Shepherd, Alexander M, Polvino, William, Mangoo-Karim, Roberto, Ballard, Kevin, Sunthornyothin, Sarat, Luther, Robert R, Pool, James L

“…Thirty-three patients with mild-to-moderate essential hypertension received either placebo or fenoldopam, a selective dopamine-1 agonist, by intravenous…”
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Sustained Hemodynamic Effects of the Selective Dopamine-1 Agonist, Fenoldopam, during 48-Hour Infusions in Hypertensive Patients: A Dose-Tolerability Study by Taylor, Addison A., Mangoo-Karim, Roberto, Ballard, Kevin D., Luther, Robert R., Pool, James L.

“…Eight patients with stage I‐II hypertension received a continuous IV infusion of the selective dopamine‐1 agonist, fenoldopam, for up to 48 hours at rates from…”
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Effects of the Renin Inhibitor A-64662 in Monkeys and Rats with Varying Baseline Plasma Renin Activity by KLEINERT, HOLLIS D, MARTIN, DONALD, CHEKAL, MARCIA A, KADAM, JILL, LULY, JAY R, PLATTNER, JACOB J, PERUN, THOMAS J, LUTHER, ROBERT R

“…The efficacy of the potent, primate selective renin inhibitor A-64662 was studied in monkeys and rats with varying baseline plasma renin activity (PRA) to…”
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Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain by Bowersox, S S, Gadbois, T, Singh, T, Pettus, M, Wang, Y X, Luther, R R

“…Male Sprague-Dawley rats were used to evaluate the antinociceptive properties of the selective N-type voltage-sensitive calcium channel (VSCC) blocker,…”
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Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain by Atanassoff, P G, Hartmannsgruber, M W, Thrasher, J, Wermeling, D, Longton, W, Gaeta, R, Singh, T, Mayo, M, McGuire, D, Luther, R R

“…Voltage-sensitive calcium channel conductance is essential for the nervous system to signal a painful event. However, intrathecal administration of L-type…”
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Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor by Glassman, H N, Kleinert, H D, Boger, R S, Moyse, D M, Griffiths, A N, Luther, R R

“…Enalkiren (A-64662), a potent, dipeptide renin inhibitor, mimics the transition state of the human renin substrate, angiotensinogen. Enalkiren has been shown…”
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Ziconotide, a new n-type calcium channel blocker, administered intrathecally for acute postoperative pain by Atanassoff, Peter G., Hartmannsgruber, Maximilian W.B., Thrasher, James, Wermeling, Dan, Longton, William, Gaeta, Raymond, Singh, Tej, Mayo, Martha, McGuire, Dawn, Luther, Robert R.

“…Background and Objectives: Voltage-sensitive calcium channel conductance is essential for the nervous system to signal a painful event. However, intrathecal…”
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Fenoldopam, a Dopamine Agonist, for Hypertensive Emergency: A Multicenter Randomized Trial by Tumlin, James A., Dunbar, Lala M., Oparil, Suzanne, Buckalew, Vardaman, Ram, C. Venkata, Mathur, Vandana, Ellis, David, McGuire, Dawn, Fellmann, Jere, Luther, Robert R.

“… Despite successful therapies for chronic hypertension, hospital admissions for hypertensive emergency more than tripled between 1983 and 1992. Objective: To…”
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Long-term treatment of angina pectoris with carteolol: a new beta-adrenergic receptor blocking agent by Luther, R R, Glassman, H N, Jordan, D C, Klepper, M J

“…Seventy-two patients entered the treatment phase of an open, long-term, dose-ranging trial of carteolol in stable, exercise-induced angina pectoris. Patients…”
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Carteolol treatment of essential hypertension: a long-term study of safety and efficacy by Luther, R R, Maurath, C J, Klepper, M J, Peckinpaugh, R O, Ringham, G L

“…The long-term safety and antihypertensive efficacy of carteolol were evaluated in an open-label, multicenter trial of 245 hypertensive patients. For those…”
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Effects of an N-type calcium channel antagonist (SNX 111; Ziconotide) on calcium-45 accumulation following fluid-percussion injury by Samii, A, Badie, H, Fu, K, Luther, R R, Hovda, D A

“…Accumulation of calcium following experimental traumatic brain injury (TBI) has been demonstrated to be a prominent pathophysiological component that can…”
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Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats by Scott Bowersox, S., Singh, Tejinder, Luther, Robert R.

“…The neuroprotective efficacy of the selective N-type voltage-sensitive calcium channel blocker, SNX-111, was evaluated in spontaneously hypertensive rats…”
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TREATMENT OF HYPERTENSIVE EMERGENCIES WITH FENOLDOPAM, A PERIPHERALLY ACTING DOPAMINE (DA1) RECEPTOR AGONIST by Ellis, David J., Luther, Robert R., Fellmann, Jere, Mathur, Vandana, McGuire, Dawn

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Pharmacokinetics of SNX-111, a selective N-type calcium channel blocker, in rats and cynomolgus monkeys by BOWERSOX, S, MANDEMA, J, TARCZY-HORNOCH, K, MILJANICH, G, LUTHER, R. R

“…SNX-111, a selective N-type voltage-sensitive calcium channel blocker, is in clinical trials for the treatment of ischemia-induced brain injury and chronic…”
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Fenoldopam: A new parenteral antihypertensive by Oparil, Suzanne, Aronson, Solomon, Deeb, G. Michael, Epstein, Murray, Levy, Jerrold H., Luther, Robert R., Prielipp, Richard, Taylor, Addison

“…A panel of clinicians from anesthesiology, surgery, nephrology, hypertension, cardiology, and pharmacology was convened to discuss pharmacologic therapeutics…”
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