Search Results - "LUSTIG, Lawrence R"

Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy by Akil, Omar, Seal, Rebecca P., Burke, Kevin, Wang, Chuansong, Alemi, Aurash, During, Matthew, Edwards, Robert H., Lustig, Lawrence R.

“…Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to loss of glutamate release at the inner hair cell afferent synapse…”
Get full text

Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model by Akil, Omar, Dyka, Frank, Calvet, Charlotte, Emptoz, Alice, Lahlou, Ghizlene, Nouaille, Sylvie, de Monvel, Jacques Boutet, Hardelin, Jean-Pierre, Hauswirth, William W., Avan, Paul, Petit, Christine, Safieddine, Saaid, Lustig, Lawrence R.

“…Autosomal recessive genetic forms (DFNB) account for most cases of profound congenital deafness. Adeno-associated virus (AAV)-based gene therapy is a promising…”
Get full text

A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records by Hoffmann, Thomas J, Keats, Bronya J, Yoshikawa, Noriko, Schaefer, Catherine, Risch, Neil, Lustig, Lawrence R

“…Age-related hearing impairment (ARHI), one of the most common sensory disorders, can be mitigated, but not cured or eliminated. To identify genetic influences…”
Get full text

Prevalence of adult unilateral hearing loss and hearing aid use in the United States by Golub, Justin S., Lin, Frank R., Lustig, Lawrence R., Lalwani, Anil K.

“…Objective The prevalence of unilateral hearing loss (UHL) in adults has not been well characterized. The objectives of this study are to determine the…”
Get full text

Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss by Li, Jiang, Akil, Omar, Rouse, Stephanie L, McLaughlin, Conor W, Matthews, Ian R, Lustig, Lawrence R, Chan, Dylan K, Sherr, Elliott H

“…Hearing loss is a significant public health concern, affecting over 250 million people worldwide. Both genetic and environmental etiologies are linked to…”
Get full text

Sensorineural Deafness and Seizures in Mice Lacking Vesicular Glutamate Transporter 3 by Seal, Rebecca P., Akil, Omar, Yi, Eunyoung, Weber, Christopher M., Grant, Lisa, Yoo, Jong, Clause, Amanda, Kandler, Karl, Noebels, Jeffrey L., Glowatzki, Elisabeth, Lustig, Lawrence R., Edwards, Robert H.

“…The expression of unconventional vesicular glutamate transporter VGLUT3 by neurons known to release a different classical transmitter has suggested novel roles…”
Get full text

Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III by Geng, Ruishuang, Omar, Akil, Gopal, Suhasini R., Chen, Daniel H.-C., Stepanyan, Ruben, Basch, Martin L., Dinculescu, Astra, Furness, David N., Saperstein, David, Hauswirth, William, Lustig, Lawrence R., Alagramam, Kumar N.

“…Usher syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by mutations in the clarin-1 gene ( CLRN1 ). Clrn1 knockout…”
Get full text

Spiral ganglion degeneration and hearing loss as a consequence of satellite cell death in saposin B-deficient mice by Akil, Omar, Sun, Ying, Vijayakumar, Sarath, Zhang, Wujuan, Ku, Tiffany, Lee, Chi-Kyou, Jones, Sherri, Grabowski, Gregory A, Lustig, Lawrence R

“…Saposin B (Sap B) is an essential activator protein for arylsulfatase A in the hydrolysis of sulfatide, a lipid component of myelin. To study Sap B's role in…”
Get full text

Biological Therapies of the Inner Ear: What Otologists Need to Consider by Schilder, Anne G.M, Blackshaw, Helen, Lenarz, Thomas, Warnecke, Athanasia, Lustig, Lawrence R, Staecker, Hinrich

Get full text

Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia by Akil, Omar, Hall-Glenn, Faith, Chang, Jolie, Li, Alfred, Chang, Wenhan, Lustig, Lawrence R, Alliston, Tamara, Hsiao, Edward C

“…Normal hearing requires exquisite cooperation between bony and sensorineural structures within the cochlea. For example, the inner ear secretes proteins such…”
Get full text

A Meta-analysis of the Complications Associated With Osseointegrated Hearing Aids by Kiringoda, Ruwan, Lustig, Lawrence R

“…OBJECTIVETo summarize available peer-reviewed literature to describe the range and rate of complications related to osseointegrated hearing aids in adult and…”
Get full text

Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane by Akil, Omar, Rouse, Stephanie L, Chan, Dylan K, Lustig, Lawrence R

“…Gene therapy, used to achieve functional recovery from sensorineural deafness, promises to grant better understanding of the underlying molecular and genetic…”
Get full text

Severe vestibular dysfunction and altered vestibular innervation in mice lacking prosaposin by Akil, Omar, Lustig, Lawrence R.

“…► Prosaposin is expressed and localized in vestibular end-organs and Scarpa's ganglia. ► Prosaposin is important for the maintenance of normal vestibular…”
Get full text

Systematic and other reviews: Criteria and complexities by Sataloff, Robert T., Bush, Matthew L., Chandra, Rakesh, Chepeha, Douglas, Rotenberg, Brian, Fisher, Edward W., Goldenberg, David, Hanna, Ehab Y., Kerschner, Joseph E., Kraus, Dennis H., Krouse, John H., Li, Daqing, Link, Michael, Lustig, Lawrence R., Selesnick, Samuel H., Sindwani, Raj, Smith, Richard J., Tysome, James, Weber, Peter C., Welling, D. Bradley

Get full text

Characterization of the human nicotinic acetylcholine receptor subunit alpha (α) 9 (CHRNA9) and alpha (α) 10 (CHRNA10) in lymphocytes by Peng, Huashan, Ferris, Robert L., Matthews, Tonya, Hiel, Hakim, Lopez-Albaitero, Andres, Lustig, Lawrence R.

“…Though the nicotinic acetylcholine receptor (nAChR) subunits α9 and α 10 have been thoroughly characterized within hair cells of the organ of Corti in the…”
Get full text

Bell's Palsy and Its Semantic Change over Time by Chern, Alexander, Mudry, Albert, Lustig, Lawrence R.

“…From 1821 to 1829, Sir Charles Bell presented cases of facial paralysis from infection, trauma, and unknown causes. As such, "Bell's palsy" initially referred…”
Get full text

Otology and Neurotology in a Post-COVID-19 World by Lustig, Lawrence R.

Get full text

Dehiscence of bone overlying the superior canal as a cause of apparent conductive hearing loss by Minor, Lloyd B, Carey, John P, Cremer, Phillip D, Lustig, Lawrence R, Streubel, Sven-Olrik, Ruckenstein, Michael J

“…To identify patients with superior semicircular canal dehiscence and apparent conductive hearing loss and to define the cause of the air-bone gap. Prospective…”
Get full text

Venous malformations of the temporal bone are a common feature in CHARGE syndrome by Friedmann, David R., Amoils, Misha, Germiller, John A., Lustig, Lawrence R., Glastonbury, Christine M., Pramanik, Bidyut K., Lalwani, Anil K.

“…Objectives/Hypothesis: CHARGE (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth and/or development, Genital and/or urinary…”
Get full text

Systematic and other reviews: Criteria and complexities by Sataloff, Robert T., Bush, Matthew L., Chandra, Rakesh, Chepeha, Douglas, Rotenberg, Brian, Fisher, Edward W., Goldenberg, David, Hanna, Ehab Y., Kerschner, Joseph E., Kraus, Dennis H., Krouse, John H., Li, Daqing, Link, Michael, Lustig, Lawrence R., Selesnick, Samuel H., Sindwani, Raj, Smith, Richard J., Tysome, James R., Weber, Peter C., Welling, D. Bradley

Get full text