Search Results - "LUSKEY, KENNETH L."

140-LB: NGM313, a Novel Activator of b-Klotho/FGFR1c, Improves Insulin Resistance and Reduces Hepatic Fat in Obese, Nondiabetic Subjects by DEPAOLI, ALEX, PHUNG, VAN, BASHIR, MUSTAFA R., MORROW, LINDA, BEYSEN, CARINE, YAN, ANDREW, LING, LEI, BAXTER, BRYAN, LUSKEY, KENNETH L., OLEFSKY, JERROLD M.

“…Background: NGM313 is a humanized monoclonal antibody activator of β-klotho/FGFR1c that has been shown to reduce HOMA-IR in obese subjects. This study compared…”
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The Amino Terminus of Insulin-responsive Aminopeptidase Causes Glut4 Translocation in 3T3-L1 Adipocytes by Waters, Steven B., D'Auria, Matt, Martin, Stuart S., Nguyen, Chris, Kozma, Lynn M., Luskey, Kenneth L.

“…The insulin-responsive aminopeptidase (IRAP) is a constituent of the vesicles that contain the insulin-regulated glucose transporter (Glut4). Like Glut4, IRAP…”
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Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum by Chin, Daniel J, Gil, Gregorio, Russell, David W, Liscum, Laura, Luskey, Kenneth L, Basu, Sandip K, Okayama, Hiroto, Berg, Paul, Goldstein, Joseph L, Brown, Michael S

“…The nucleotide sequence of a 4.8-kilobase mRNA for hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase, the endoplasmic reticulum enzyme that controls…”
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Coordinate regulation of amylin and insulin expression in response to hypoglycemia and fasting by ALAM, T, LING CHEN, OGAWA, A, LEFFERT, J. D, UNGER, R. H, LUSKEY, K. L

“…Amylin is a 37-amino acid peptide synthesized in the pancreatic beta-cell and cosecreted with insulin. In situ hybridization of nondiabetic rat pancreas shows…”
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HgiAI polymorphism near the HMGCR promoter by Leitersdorf, E, Luskey, K L

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ScrFI polymorphism in the 2nd intron of the HMGCR gene by Leitersdorf, E, Hwang, M, Luskey, K L

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Stimulation of the Synthesis of Very Low Density Lipoproteins in Rooster Liver by Estradiol by Luskey, Kenneth L., Brown, Michael S., Goldstein, Joseph L.

“…A sensitive, specific, and rapid immunochemical method for the measurement of the synthesis of lipoproteins in rooster liver is described. Incubation of liver…”
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Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment by OGAWA, A, HARRIS, V, MCCORKLE, S. K, UNGER, R. H, LUSKEY, K. L

“…Amylin, a peptide copackaged with insulin in beta-cell granules, was measured in the effluent of the perfused rat pancreases by means of a newly developed…”
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HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions by Reynolds, G A, Basu, S K, Osborne, T F, Chin, D J, Gil, G, Brown, M S, Goldstein, J L, Luskey, K L

“…The rate-limiting enzyme of cholesterol biosynthesis, HMG CoA reductase, is controlled by negative feedback regulation of transcription. We have isolated the…”
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Rat Amylin: Cloning and Tissue-Specific Expression in Pancreatic Islets by Leffert, Jonathan D., Newgard, Christopher B., Okamoto, Hiroshi, Milburn, Joseph L., Luskey, Kenneth L.

“…Amyloid deposits in the islets of Langerhans of the pancreas are a common finding in non-insulin-dependent diabetes mellitus. The main protein constituent of…”
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Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor by Russell, D W, Schneider, W J, Yamamoto, T, Luskey, K L, Brown, M S, Goldstein, J L

“…The nucleotide sequence of a partial cDNA for the bovine low-density lipoprotein (LDL) receptor revealed an open reading frame of 264 amino acids that encodes…”
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Possible links between amylin and diabetes. Amylin is released into the blood stream along with insulin by Luskey, K L

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Human Genes Involved in Cholesterol Metabolism: Chromosomal Mapping of the Loci for the Low Density Lipoprotein Receptor and 3-hydroxy-3-methylglutaryl-coenzyme A Reductase with cDNA Probes by Lindgren, Valerie, Luskey, Kenneth L., Russell, David W., Francke, Uta

“…Cellular cholesterol metabolism is regulated primarily through the coordinate expression of two proteins, the low density lipoprotein (LDL) receptor and…”
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Biogenesis of the Crystalloid Endoplasmic Reticulum in UT-1 Cells: Evidence That Newly Formed Endoplasmic Reticulum Emerges from the Nuclear Envelope by Pathak, Ravindra K., Luskey, Kenneth L., Richard G. W. Anderson

“…The crystalloid endoplasmic reticulum (ER), a specialized smooth ER of the compactin-resistant UT-1 cell, is composed of multiple membrane tubules packed…”
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Conservation of Promoter Sequence but not Complex Intron Splicing Pattern in Human and Hamster Genes for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase by Luskey, Kenneth L.

“…Regulation of the expression of 3-hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase is a critical step in controlling cholesterol synthesis. Previous…”
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Regulation of Synthesis and Degradation of 3-hydroxy-3-methylglutaryl-coenzyme A Reductase by Low Density Lipoprotein and 25-hydroxycholesterol in UT-1 Cells by Faust, Jerry R., Luskey, Kenneth L., Chin, Daniel J., Goldstein, Joseph L., Brown, Michael S.

“…UT-1 cells are a clone of Chinese hamster ovary cells that were selected to grow in the presence of compactin, a competitive inhibitor of…”
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Appearance of Crystalloid Endoplasmic Reticulum in Compactin-Resistant Chinese Hamster Cells with a 500-Fold Increase in 3-hydroxy-3-methylglutaryl-coenzyme A Reductase by Chin, Daniel J., Luskey, Kenneth L., Richard G. W. Anderson, Faust, Jerry R., Goldstein, Joseph L., Brown, Michael S.

“…We have developed a line of Chinese hamster ovary cells with a 500-fold increase in 3-hydroxy-3-methylglutarylcoenzyme A reductase, the membrane-bound enzyme…”
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Structure and expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase by Luskey, K L

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Molecular Cloning of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase and Evidence for Regulation of Its mRNA by Chin, Daniel J., Luskey, Kenneth L., Faust, Jerry R., MacDonald, Raymond J., Brown, Michael S., Goldstein, Joseph L.

“…A recombinant plasmid containing a 1.2-kilobase cDNA for 3-hydroxy-3-methylglutaryl coenzyme A reductase was isolated from a cDNA library prepared from UT-1…”
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Regulation of cholesterol synthesis: mechanism for control of HMG CoA reductase by Luskey, K L

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