Search Results - "LUO, Wentian"

Structural basis of seamless excision and specific targeting by piggyBac transposase by Chen, Qiujia, Luo, Wentian, Veach, Ruth Ann, Hickman, Alison B., Wilson, Matthew H., Dyda, Fred

“…The piggyBac DNA transposon is used widely in genome engineering applications. Unlike other transposons, its excision site can be precisely repaired without…”
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Epidermal growth factor receptor activation is essential for kidney fibrosis development by Cao, Shirong, Pan, Yu, Terker, Andrew S., Arroyo Ornelas, Juan Pablo, Wang, Yinqiu, Tang, Jiaqi, Niu, Aolei, Kar, Sarah Abu, Jiang, Mengdi, Luo, Wentian, Dong, Xinyu, Fan, Xiaofeng, Wang, Suwan, Wilson, Matthew H., Fogo, Agnes, Zhang, Ming-Zhi, Harris, Raymond C.

“…Fibrosis is the progressive accumulation of excess extracellular matrix and can cause organ failure. Fibrosis can affect nearly every organ including kidney…”
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Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy by Luo, Wentian, Olaru, Florina, Miner, Jeffrey H, Beck, Jr, Laurence H, van der Vlag, Johan, Thurman, Joshua M, Borza, Dorin-Bogdan

“…Membranous nephropathy is an immune kidney disease caused by IgG antibodies that form glomerular subepithelial immune complexes. Proteinuria is mediated by…”
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Comprehensively analysis of immunophenotyping signature in triple-negative breast cancer patients based on machine learning by Tang, Lijuan, Zhang, Zhe, Fan, Jun, Xu, Jing, Xiong, Jiashen, Tang, Lu, Jiang, Yan, Zhang, Shu, Zhang, Gang, Luo, Wentian, Xu, Yan

“…Immunotherapy is a promising strategy for triple-negative breast cancer (TNBC) patients, however, the overall survival (OS) of 5-years is still not…”
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Kidney-specific transposon-mediated gene transfer in vivo by Woodard, Lauren E., Cheng, Jizhong, Welch, Richard C., Williams, Felisha M., Luo, Wentian, Gewin, Leslie S., Wilson, Matthew H.

“…Methods enabling kidney-specific gene transfer in adult mice are needed to develop new therapies for kidney disease. We attempted kidney-specific gene transfer…”
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Neonatal Fc Receptor Promotes Immune Complex-Mediated Glomerular Disease by OLARU, Florina, WENTIAN LUO, HANI SULEIMAN, ST. JOHN, Patricia L, GE, Linna, MEZO, Adam R, SHAW, Andrey S, ABRAHAMSON, Dale R, MINER, Jeffrey H, BORZA, Dorin-Bogdan

“…The neonatal Fc receptor (FcRn) is a major regulator of IgG and albumin homeostasis systemically and in the kidneys. We investigated the role of FcRn in the…”
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Genome Engineering Renal Epithelial Cells for Enhanced Volume Transport Function by Wilson, Matthew H., Veach, Ruth Ann, Luo, Wentian, Welch, Richard C., Roy, Shuvo, Fissell, William H.

“…Introduction Bioengineering an implantable artificial kidney (IAK) will require renal epithelial cells capable of reabsorption of salt and water. We used…”
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Kidney collecting duct cells make vasopressin in response to NaCl-induced hypertonicity by Arroyo, Juan Pablo, Terker, Andrew S, Zuchowski, Yvonne, Watts, Jason A, Bock, Fabian, Meyer, Cameron, Luo, Wentian, Kapp, Meghan E, Gould, Edward R, Miranda, Adam X, Carty, Joshua, Jiang, Ming, Vanacore, Roberto M, Hammock, Elizabeth, Wilson, Matthew H, Zent, Roy, Zhang, Mingzhi, Bhave, Gautam, Harris, Raymond C

“…Vasopressin has traditionally been thought to be produced by the neurohypophyseal system and then released into the circulation where it regulates water…”
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Ligand-independent integrin β1 signaling supports lung adenocarcinoma development by Haake, Scott M, Plosa, Erin J, Kropski, Jonathan A, Venton, Lindsay A, Reddy, Anupama, Bock, Fabian, Chang, Betty T, Luna, Allen J, Nabukhotna, Kateryna, Xu, Zhi-Qi, Prather, Rebecca A, Lee, Sharon, Tanjore, Harikrishna, Polosukhin, Vasiliy V, Viquez, Olga M, Jones, Angela, Luo, Wentian, Wilson, Matthew H, Rathmell, W Kimryn, Massion, Pierre P, Pozzi, Ambra, Blackwell, Timothy S, Zent, Roy

“…Integrins - the principal extracellular matrix (ECM) receptors of the cell - promote cell adhesion, migration, and proliferation, which are key events for…”
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Hydrodynamic Renal Pelvis Injection for Non-viral Expression of Proteins in the Kidney by Woodard, Lauren E, Welch, Richard C, Williams, Felisha M, Luo, Wentian, Cheng, Jizhong, Wilson, Matthew H

“…Hydrodynamic injection creates a local, high-pressure environment to transfect various tissues with plasmid DNA and other substances. Hydrodynamic tail vein…”
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Novel X-linked glomerulopathy is associated with a COL4A5 missense mutation in a non-collagenous interruption by Becknell, Brian, Zender, Gloria A., Houston, Ronald, Baker, Peter B., McBride, Kim L., Luo, Wentian, Hains, David S., Borza, Dorin-Bogdan, Schwaderer, Andrew L.

“…A novel COL4A5 mutation causes rapid progression to end-stage renal disease in males, despite the absence of clinical and biopsy findings associated with…”
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A Yeast Assay Probes the Interaction between Botulinum Neurotoxin Serotype B and Its SNARE Substrate by Fang, Hong, Luo, Wentian, Henkel, Jim, Barbieri, Joseph, Green, Neil

“…The seven functionally distinct serotypes (A-G) of botulinum neurotoxin (BoNT) are dichains consisting of light chain (LC) with zinc-dependent endoprotease…”
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Abstract 1418: Testing and Optimization of piggyBac Using Transposase mRNA and Transposon DNA Towards Gene Therapy for Kidney Disease by Rivera, Krystal, Menshikh, Anna, Luo, Wentian, Wilson, Matthew

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Cargo Sequences Are Important for Som1p-dependent Signal Peptide Cleavage in Yeast Mitochondria by Liang, Haobo, Luo, Wentian, Green, Neil, Fang, Hong

“…The inner membrane protease (IMP) has two catalytic subunits, Imp1p and Imp2p, that exhibit nonoverlapping substrate specificity in mitochondria of the yeast…”
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Factors Governing Nonoverlapping Substrate Specificity by Mitochondrial Inner Membrane Peptidase by Luo, Wentian, Chen, Xuemin, Fang, Hong, Green, Neil

“…At least three peptidases are involved in cleaving presequences from imported mitochondrial proteins. One of the peptidase, the inner membrane peptidase, has…”
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Cognate restriction of transposition by piggyBac-like proteins by Beckermann, Thomas M, Luo, Wentian, Wilson, Catherine M, Veach, Ruth Ann, Wilson, Matthew H

“…Abstract Mobile genetic elements have been harnessed for gene transfer for a wide variety of applications including generation of stable cell lines,…”
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Preparation and performance study of recyclable microsphere soil conditioner based on magnetic metal organic framework structure by Xiang, Kailing, Li, Shuhong, Chen, Jiacheng, Wu, Youzhi, Li, Yakun, Yang, Fan, Pan, Ye, Dai, Weisen, Wang, Jincheng, Wang, Xinyi, Luo, Wentian, He, Zijian, Zhang, Hua

“…The soil environment affects agroecology and the soil environment; however, there are no reports on recyclable, waste-free soil conditioners that can both…”
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Comparative analysis of chimeric ZFP-, TALE- and Cas9-piggyBac transposases for integration into a single locus in human cells by Luo, Wentian, Galvan, Daniel L, Woodard, Lauren E, Dorset, Dan, Levy, Shawn, Wilson, Matthew H

“…Integrating DNA delivery systems hold promise for many applications including treatment of diseases; however, targeted integration is needed for improved…”
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Transposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells by Luo, Wentian, Hickman, Alison B, Genzor, Pavol, Ghirlando, Rodolfo, Furman, Christopher M, Menshikh, Anna, Haase, Astrid, Dyda, Fred, Wilson, Matthew H

“…DNA transposon systems are widely used in mammalian cells for genetic modification experiments, but their regulation remains poorly understood. We used…”
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Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease by Shen, Cong-Rong, Jia, Xiao-Yu, Luo, Wentian, Olaru, Florina, Cui, Zhao, Zhao, Ming-Hui, Borza, Dorin-Bogdan

“…Antiglomerular basement membrane (anti-GBM) disease is characterized by GN and often pulmonary hemorrhage, mediated by autoantibodies that typically recognize…”
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