Search Results - "LUNGARELLA, GIUSEPPE"

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping by Kaur, Gagandeep, Lungarella, Giuseppe, Rahman, Irfan

“…The current pandemic of COVID-19 has caused severe morbidity and mortality across the globe. People with a smoking history have severe disease outcomes by…”
Get full text

Comments on "Air Space Distension Precedes Spontaneous Fibrotic Remodeling and Impaired Cholesterol Metabolism in the Absence of Surfactant Protein C" by Lungarella, Giuseppe, Lucattelli, Monica, Cavarra, Eleonora, De Cunto, Giovanna

Get full text

Smoking Cessation in Mice Does Not Switch off Persistent Lung Inflammation and Does Not Restore the Expression of HDAC2 and SIRT1 by De Cunto, Giovanna, De Meo, Simone, Bartalesi, Barbara, Cavarra, Eleonora, Lungarella, Giuseppe, Lucattelli, Monica

“…Once COPD is established, pulmonary lesions can only progress and smoking cessation by itself is not sufficient to switch off persistent lung inflammation…”
Get full text

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease by Hatzelmann, Armin, Morcillo, Esteban J, Lungarella, Giuseppe, Adnot, Serge, Sanjar, Shahin, Beume, Rolf, Schudt, Christian, Tenor, Hermann

“…Abstract After more than two decades of research into phosphodiesterase 4 (PDE4) inhibitors, roflumilast…”
Get full text

Sarcopenia in Chronic Kidney Disease: Focus on Advanced Glycation End Products as Mediators and Markers of Oxidative Stress by Dozio, Elena, Vettoretti, Simone, Lungarella, Giuseppe, Messa, Piergiorgio, Corsi Romanelli, Massimiliano M

“…Sarcopenia is common in chronic kidney disease (CKD), and it is independently associated with morbidity and mortality. Advanced glycation end products (AGE)…”
Get full text

P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema by Lucattelli, Monica, Cicko, Sanja, Müller, Tobias, Lommatzsch, Marek, De Cunto, Giovanna, Cardini, Silvia, Sundas, William, Grimm, Melanie, Zeiser, Robert, Dürk, Thorsten, Zissel, Gernot, Sorichter, Stephan, Ferrari, Davide, Di Virgilio, Francesco, Virchow, J Christian, Lungarella, Giuseppe, Idzko, Marco

“…Extracellular ATP is up-regulated in the airways of patients with chronic obstructive pulmonary disease, and may contribute to the pathogenesis of the disease…”
Get full text

Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung by Lucattelli, Monica, Fineschi, Silvia, Selvi, Enrico, Garcia Gonzalez, Estrella, Bartalesi, Barbara, De Cunto, Giovanna, Lorenzini, Sauro, Galeazzi, Mauro, Lungarella, Giuseppe

“…Ajulemic acid (AjA) is a synthetic analogue of tetrahydrocannabinol that can prevent and limit progression of skin fibrosis in experimental systemic sclerosis…”
Get full text

Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema by Lunghi, Benedetta, De Cunto, Giovanna, Cavarra, Eleonora, Fineschi, Silvia, Bartalesi, Barbara, Lungarella, Giuseppe, Lucattelli, Monica

“…The adaptor protein p66Shc regulates intracellular oxidant levels through the modulation of a forkhead-related transcription factor (FOXO3a). The genetic…”
Get full text

Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics by Dalle-Donne, Isabella, Scaloni, Andrea, Giustarini, Daniela, Cavarra, Eleonora, Tell, Gianluca, Lungarella, Giuseppe, Colombo, Roberto, Rossi, Ranieri, Milzani, Aldo

“…I. Introduction 00  II. Reactive Oxygen and Nitrogen Species 00  III. Biological Markers of Oxidative/Nitrosative Stress 00  IV. Oxidative/Nitrosative Stress…”
Get full text

Roflumilast Fully Prevents Emphysema in Mice Chronically Exposed to Cigarette Smoke by Martorana, Piero A, Beume, Rolf, Lucattelli, Monica, Wollin, Lutz, Lungarella, Giuseppe

“…There is a need for new agents capable of suppressing the inflammatory response in chronic obstructive pulmonary disease. This study evaluated the effects of…”
Get full text

Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema by Cicko, Sanja, Lucattelli, Monica, Müller, Tobias, Lommatzsch, Marek, De Cunto, Giovanna, Cardini, Silvia, Sundas, William, Grimm, Melanine, Zeiser, Robert, Dürk, Thorsten, Zissel, Gernot, Boeynaems, Jean-Marie, Sorichter, Stephan, Ferrari, Davide, Di Virgilio, Francesco, Virchow, J Christian, Lungarella, Giuseppe, Idzko, Marco

“…Extracellular ATP acts as a "danger signal" and can induce inflammation by binding to purinergic receptors. Chronic obstructive pulmonary disease is one of the…”
Get full text

P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis by Müller, Tobias, Fay, Susanne, Vieira, Rodolfo Paula, Karmouty-Quintana, Harry, Cicko, Sanja, Ayata, Cemil Korcan, Zissel, Gernot, Goldmann, Torsten, Lungarella, Giuseppe, Ferrari, Davide, Di Virgilio, Francesco, Robaye, Bernard, Boeynaems, Jean-Marie, Lazarowski, Eduardo R., Blackburn, Michael R., Idzko, Marco

“…Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and very few available treatment options. The involvement of the purinergic receptor…”
Get full text

Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice by Fineschi, Silvia, De Cunto, Giovanna, Facchinetti, Fabrizio, Civelli, Maurizio, Imbimbo, Bruno P, Carnini, Chiara, Villetti, Gino, Lunghi, Benedetta, Stochino, Stefania, Gibbons, Deena L, Hayday, Adrian, Lungarella, Giuseppe, Cavarra, Eleonora

“…The role of the receptor for advanced glycation end products (RAGE) in promoting the inflammatory response through activation of NF-κB pathway is well…”
Get full text

In Vivo Electroporation-Mediated, Intrahepatic Alpha1 Antitrypsin Gene Transfer Reduces Pulmonary Emphysema in Pallid Mice by Sutter, Marco, Cremona, Tiziana, Nita, Izabela, Cavarra, Eleonora, Lungarella, Giuseppe, Lewis, Eli, Schittny, Johannes, Geiser, Thomas, Gazdhar, Amiq

“…Rationale: Mutation in the alpha1 antitrypsin (AAT) gene leads to low circulating levels of AAT, which is associated with several disease processes including…”
Get full text

Middermal Elastolysis: Dermal Fibroblasts Cooperate with Inflammatory Cells to the Elastolytic Disorder by Cavarra, Eleonora, Fimiani, Michele, Miracco, Clelia, de Santi, Maria Margherita, Lamberti, Arianna, De Cunto, Giovanna, Lungarella, Giuseppe

“…Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not…”
Get full text

Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease by Mall, Marcus, Hirsch, Emilio, De Rose, Virginia, Doring, Gerd, Lungarella, Giuseppe, Campa, Carlo Cosimo, Ulrich, Martina, Hoxha, Eriola, Lucattelli, Monica, Ciraolo, Elisa, Galluzzo, Maria, Zhou-Suckow, Zhe

“…Purpose. Neutrophil-dominated airway inflammation is a key feature of progressive lung damage in cystic fibrosis (CF). Thus, reducing airway inflammation is a…”
Get full text

Absence of Proteinase-Activated Receptor-1 Signaling in Mice Confers Protection from fMLP-Induced Goblet Cell Metaplasia by Atzori, Luigi, Lucattelli, Monica, Scotton, Chris J, Laurent, Geoffrey J, Bartalesi, Barbara, De Cunto, Giovanna, Lunghi, Benedetta, Chambers, Rachel C, Lungarella, Giuseppe

“…The morphological features of chronic obstructive pulmonary disease in man include emphysema and chronic bronchitis associated with mucus hypersecretion. These…”
Get full text

Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice by Martorana, Piero A, Lunghi, Benedetta, Lucattelli, Monica, De Cunto, Giovanna, Beume, Rolf, Lungarella, Giuseppe

“…We reported that roflumilast, a phosphodiesterase 4 inhibitor, given orally at 5 mg/kg to mice prevented the development of emphysema in a chronic model of…”
Get full text

Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis by Lasky, J A, Ortiz, L A, Tonthat, B, Hoyle, G W, Corti, M, Athas, G, Lungarella, G, Brody, A, Friedman, M

“…Connective tissue growth factor (CTGF) is a newly described 38-kDa peptide mitogen for fibroblasts and a promoter of connective tissue deposition in the skin…”
Get full text

Differential thiol status in blood of different mouse strains exposed to cigarette smoke by Rossi, Ranieri, Giustarini, Daniela, Fineschi, Silvia, De Cunto, Giovanna, Lungarella, Giuseppe, Cavarra, Eleonora

“…C57Bl/6J, DBA/2 and ICR mouse strains are known to possess different susceptibilities to developing emphysema after exposure to cigarette smoke with DBA/2 and…”
Get more information