Search Results - "LUNDY, Paul M"

Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning by LUNDY, Paul M, RAVEH, Lily, AMITAI, Gabriel

“…The traditional therapeutic treatment of organophosphate cholinesterase inhibitor (nerve agents) poisoning consists of co-treatment with an antimuscarinic…”
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Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning by Lundy, Paul M, Hamilton, Murray G, Sawyer, Thomas W, Mikler, John

“…Abstract The oximes pralidoxime (2-PAM), its dimethanesulphonate salt derivative P2S, and obidoxime (toxogonin) are currently licensed and fielded for the…”
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Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin by Huang, Yue-Jin, Lundy, Paul M, Lazaris, Anthoula, Huang, Yue, Baldassarre, Hernan, Wang, Bin, Turcotte, Carl, Côté, Mélanie, Bellemare, Annie, Bilodeau, Annie S, Brouillard, Sandra, Touati, Madjid, Herskovits, Peter, Bégin, Isabelle, Neveu, Nathalie, Brochu, Eric, Pierson, Janice, Hockley, Duncan K, Cerasoli, Douglas M, Lenz, David E, Wilgus, Harvey, Karatzas, Costas N, Langermann, Solomon

“…Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD50 of organophosphorus compounds. A prerequisite for such…”
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Medical countermeasures to WMDs: Defence research for civilian and military use by Hamilton, Murray G, Lundy, Paul M

“…Abstract This document will address the contributions of defence research to both military and civilian applications. Compared to civilian research…”
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The pharmacokinetics and pharmacodynamics of two HI-6 salts in swine and efficacy in the treatment of GF and soman poisoning by Lundy, Paul M., Hill, Ira, Lecavalier, Pierre, Hamilton, Murray G., Vair, Cory, Davidson, Corey, Weatherby, Kendal L., Berger, Bradley J.

“…Anesthetized pigs were injected i.m. with 500 mg HI-6 dichloride (HI-6 2Cl) (1-[[[4-(aminocarbonyl)-pyridinio]methoxy]methyl]-2[(hydroxyimino)methyl]pyridinium…”
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Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination by Hamilton, Murray G, Hill, Ira, Conley, John, Sawyer, Thomas W, Caneva, Duane C, Lundy, Paul M

“…O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) is an extremely toxic organophosphate nerve agent that has been weaponized and stockpiled in a…”
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Pharmacological differentiation of the P2X7 receptor and the maitotoxin-activated cationic channel by LUNDY, Paul M, NELSON, Peggy, LEI MI, FREW, Robert, MINAKER, Sean, VAIR, Cory, SAWYER, Thomas W

“…The ATP-P2X(7) receptor subtype and a maitotoxin-activated ion channel were studied to determine factors which identify them as separate entities in the…”
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Stimulation of Ca2+ influx through ATP receptors on rat brain synaptosomes: identification of functional P2X7 receptor subtypes by Lundy, Paul M, Hamilton, Murray G, Mi, Lei, Gong, Wenrong, Vair, Cory, Sawyer, Thomas W, Frew, Robert

“…ATP receptors of the P2X class have previously been identified on autonomic nerve endings and on a limited population of CNS neurons. In the present study P2X…”
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Effects of bis(2-chloroethyl)sulfide on ATP receptor-mediated responses of the rat vas deferens: possible relationship to cytotoxicity by Lundy, P M, Sawyer, T W, Hand, B T, Frew, R

“…Extracellular ATP is a broad-spectrum cytotoxic agent that produces effects via cell surface P2 purinoceptors. The ligand-gated P2X purinoceptor subtype has…”
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A comparison of the effects of sarin and succinylcholine on respiratory parameters in anesthetized domestic swine by DUNCAN, E. J, CONLEY, John D, GRYCHOWSKI, Kristen D, CONLEY, Seamus A, LUNDY, Paul M, HAMILTON, Murray G, SAWYER, Thomas W

“…Differences in the "respiratory paralysis" caused by sarin (GB) and succinylcholine (SDC) were observed in a domestic swine model using a bedside pulmonary…”
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Differential effects of ketamine isomers on neuronal and extraneuronal catecholamine uptake mechanisms by LUNDY, P. M, LOCKWOOD, P. A, THOMPSON, G, FREW, R

“…Contractile responses of isolated rabbit aortic strips to epinephrine and norepinephrine were potentiated in a dose-related manner by (+) ketamine but not by…”
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Stimulation of Ca 2+ influx through ATP receptors on rat brain synaptosomes: identification of functional P2X 7 receptor subtypes by Lundy, Paul M, Hamilton, Murray G, Mi, Lei, Gong, Wenrong, Vair, Cory, Sawyer, Thomas W, Frew, Robert

“…ATP receptors of the P2X class have previously been identified on autonomic nerve endings and on a limited population of CNS neurons. In the present study P2X…”
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Stimulation of Ca(2+) influx through ATP receptors on rat brain synaptosomes: identification of functional P2X(7) receptor subtypes by Lundy, Paul M, Hamilton, Murray G, Mi, Lei, Gong, Wenrong, Vair, Cory, Sawyer, Thomas W, Frew, Robert

“…1. ATP receptors of the P2X class have previously been identified on autonomic nerve endings and on a limited population of CNS neurons. 2. In the present…”
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Ketamine: evidence of tissue specific inhibition of neuronal and extraneuronal catecholamine uptake processes by Lundy, P M, Gverzdys, S, Frew, R

“…Ketamine (1.1 X 10(-5) to 3.7 X 10(-4) M) potentiated catecholamine responses of rat anococcygeus muscle and rabbit aorta in vitro. In the anococcygeus,…”
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Ketamine potentiates catecholamine responses of vascular smooth muscle by inhibition of extraneuronal uptake by Lundy, P M, Frew, R

“…Effects of ketamine on responses to sympathomimetic amines were studied using isolated aortic and pulmonary artery strips from the rabbit. Ketamine (1.1 x…”
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The ganglionic blocking properties of the cholinesterase reactivator, HS-6 by Lundy, P M

“…Following intravenous administration of the cholinesterase reactivator HS-6 (30 mg/kg), blood pressure fell (up to 50 mmHg) and maximal blood levels of HS-6…”
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Cyclic GMP concentrations in cerebellum following organophosphate administration by Lundy, P M, Magor, G F

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Pharmacological differentiation of the P2X 7 receptor and the maitotoxin-activated cationic channel by Lundy, Paul M., Nelson, Peggy, Mi, Lei, Frew, Robert, Minaker, Sean, Vair, Cory, Sawyer, Thomas W.

“…The ATP-P2X 7 receptor subtype and a maitotoxin-activated ion channel were studied to determine factors which identify them as separate entities in the control…”
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A role for Q type Ca 2+ channels in neurotransmission in the rat urinary bladder by Frew, Robert, Lundy, Paul M.

“…In isolated bladder strips of the rat, a substantial component (46%) of the Ca 2+ ‐dependent contractile response to electrical field stimulation (5 Hz) was…”
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Effect of omega-agatoxin-IVA on autonomic neurotransmission by Lundy, P M, Frew, R

“…omega-Agatoxin-IVA, a peptide from the venom of the funnel-web spider Agelenopsis aperta and a P type Ca2+ channel inhibitor, was examined for effects on…”
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