Search Results - "LUND, P. K"

A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora by Rigby, R J, Hunt, M R, Scull, B P, Simmons, J G, Speck, K E, Helmrath, M A, Lund, P K

“…Ileocaecal resection (ICR) is common in Crohn's disease. Inflammation and fibrosis frequently recur at the site of anastomosis or in the small intestine (SI)…”
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Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon by RIGBY, R. J, SIMMONS, J. G, GREENHALGH, C. J, ALEXANDER, W. S, LUND, P. K

“…Intestinal injury or chronic inflammation induce cytokines that promote crypt regeneration and mucosal repair. If excessive or prolonged, such mechanisms may…”
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Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I by Ohneda, K, Ulshen, MH, Fuller, CR, D'Ercole, AJ, Lund, PK

“…BACKGROUND & AIMS: Growth hormone and insulin-like growth factor I (IGF- I) stimulate small bowel growth. The aim of this study was to analyze whether IGF-I…”
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Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury by Sanz, S, Pucilowska, J B, Liu, S, Rodríguez-Ortigosa, C M, Lund, P K, Brenner, D A, Fuller, C R, Simmons, J G, Pardo, A, Martínez-Chantar, M-L, Fagin, J A, Prieto, J

“…Background/Aim: Hepatic stellate cells (HSCs) express α-smooth muscle actin (αSMA) and acquire a profibrogenic phenotype upon activation by noxious stimuli…”
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Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth by Simmons, J G, Ling, Y, Wilkins, H, Fuller, C R, D'Ercole, A J, Fagin, James, Lund, P K

“…Insulin-like growth factor I (IGF-I) potently stimulates intestinal growth. Insulin receptor substrate-1 (IRS-1) mediates proliferative and antiapoptotic…”
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Case Report: Renal Transplantation in Patients with Pre‐existing Hypogammaglobulinemia by Lund, K. P., Bruunsgaard, H., Marquart, H. V., Sørensen, S. S.

“…Hypogammaglobulinemia (HGG) is well‐characterized as a common phenomenon after kidney transplantation. However, no reports of pre‐existing HGG from kidney…”
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Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus by SMITH, D. R, HOYT, E. C, GALLAGHER, M, SCHWABE, R. F, LUND, P. K

“…Activator protein-1 (AP-1) was examined at multiple levels (mRNA, DNA binding, composition) in hippocampus of young and aged rats that were behaviorally…”
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High rate of galactose‐alpha‐1,3‐galactose sensitization in both eosinophilic esophagitis and patients undergoing upper endoscopy by Burk, C. M., Beitia, R., Lund, P. K., Dellon, E. S.

“…Summary Eosinophilic esophagitis (EoE) is an antigen/allergy‐mediated chronic inflammatory condition. The rapid rise in the number of cases of EoE suggests an…”
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Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study by Jin, S L, Han, V K, Simmons, J G, Towle, A C, Lauder, J M, Lund, P K

“…Although glucagonlike immunoreactants (GLIs) are present in the central nervous system of several mammalian species, their structural relationship with…”
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Cobalamin deficiency in general practice. assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies by HØLLELAND, G, SCHNEEDE, J, UELAND, P. M, LUND, P. K, REFSUM, H, SANDBERG, S

“…Diagnosing cobalamin deficiency is often difficult. We investigated the diagnostic strategies that 224 general practitioners used to assess cobalamin status…”
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Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues by Lund, P K, Moats-Staats, B M, Hynes, M A, Simmons, J G, Jansen, M, D'Ercole, A J, Van Wyk, J J

“…Somatomedin-C or insulin-like growth factor I (Sm-C/IGF-I) and insulin-like growth factor II (IGF-II) have been implicated in the regulation of fetal growth…”
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Increased expression of type 1 insulin-like growth factor receptor messenger rna in rat hippocampal formation is associated with aging and behavioral impairment by Stenvers, K.L., Lund, P.K., Gallagher, M.

“…Insulin-like growth factor messenger RNAs are expressed in adult rat brain. However, little is known about the effects of aging on the expression of the…”
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GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus by Helm, K A, Haberman, R P, Dean, S L, Hoyt, E C, Melcher, T, Lund, P K, Gallagher, M

“…Memory storage in the brain requires protein synthesis initiated through signaling pathways that control transcription. Such mechanisms are under active…”
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Differential inhibition of postnatal brain, spinal cord and body growth by a growth hormone antagonist by McIlwain, D L, Hoke, V B, Kopchick, J J, Fuller, C R, Lund, P K

“…Growth hormone (GH) plays an incompletely understood role in the development of the central nervous system (CNS). In this study, we use transgenic mice…”
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Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus by Victor K. M. Han, D'Ercole, A. Joseph, Lund, P. Kay

“…The somatomedins or insulin-like growth factors (IGFs) are synthesized in many organs and tissues, but the specific cells that synthesize them in vivo have not…”
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Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone by Ulshen, M H, Dowling, R H, Fuller, C R, Zimmermann, E M, Lund, P K

“…Transgenic mice with a bovine growth hormone gene linked to a mouse metallothionein I promoter (growth hormone transgenics) are a model of chronic growth…”
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Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats by McCall, R D, Haskill, S, Zimmermann, E M, Lund, P K, Thompson, R C, Sartor, R B

“…Subserosal injection of purified group A streptococcal peptidoglycan-polysaccharide (PG-APS) induces chronic relapsing granulomatous enterocolitis and systemic…”
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Phenylboronic Acid−Salicylhydroxamic Acid Bioconjugates. 2. Polyvalent Immobilization of Protein Ligands for Affinity Chromatography by Wiley, Jean P, Hughes, Karin A, Kaiser, Robert J, Kesicki, Edward A, Lund, Kevin P, Stolowitz, Mark L

“…Phenylboronic acid bioconjugates prepared from alkaline phosphatase by reaction with either 2,5-dioxopyrrolidinyl…”
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Intestinal fibrosis in human and experimental inflammatory bowel disease by Lund, P Kay, Zuniga, Carmen C

“…Fibrosis is a serious complication of Crohn disease for which there is no effective therapy. It is unclear why fibrosis, particularly fibrosis of the mucosal…”
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Regulation and localization of the insulin-like growth factor system in small bowel during altered nutrient status by Winesett, D E, Ulshen, M H, Hoyt, E C, Mohapatra, N K, Fuller, C R, Lund, P K

“…Insulin-like growth factor-I (IGF-I) may regulate small bowel growth. Analyses here in ad libitum-fed, fasted, and refed rats demonstrate that during fasting…”
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