Search Results - "LUND, ASGER"

The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes by Hædersdal, Sofie, Lund, Asger, Knop, Filip K., Vilsbøll, Tina

“…Type 2 diabetes is a disease involving both inadequate insulin levels and increased glucagon levels. While glucagon and insulin work together to achieve…”
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Glucagon Clearance is Preserved in Type 2 Diabetes by Grøndahl, Magnus F G, Lund, Asger, Bagger, Jonatan I, Petersen, Tonny S, Wewer Albrechtsen, Nicolai J, Holst, Jens J, Vilsbøll, Tina, Christensen, Mikkel B, Knop, Filip K

“…Hyperglucagonemia is a common observation in both obesity and type 2 diabetes, and the etiology is primarily thought to be hypersecretion of glucagon. We…”
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Glucose-Dependent Insulinotropic Polypeptide (GIP) Inhibits Bone Resorption Independently of Insulin and Glycemia by Christensen, Mikkel B, Lund, Asger, Calanna, Salvatore, Jørgensen, Niklas R, Holst, Jens J, Vilsbøll, Tina, Knop, Filip K

“…The gut hormone glucose-dependent insulinotropic polypeptide (GIP) causes postprandial insulin release and inhibits bone resorption assessed by…”
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The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion-A Review by Mathiesen, David S, Bagger, Jonatan I, Bergmann, Natasha C, Lund, Asger, Christensen, Mikkel B, Vilsbøll, Tina, Knop, Filip K

“…The gut-derived incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted after meal ingestion and…”
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Evidence of Extrapancreatic Glucagon Secretion in Man by Lund, Asger, Bagger, Jonatan I, Wewer Albrechtsen, Nicolai J, Christensen, Mikkel, Grøndahl, Magnus, Hartmann, Bolette, Mathiesen, Elisabeth R, Hansen, Carsten P, Storkholm, Jan H, van Hall, Gerrit, Rehfeld, Jens F, Hornburg, Daniel, Meissner, Felix, Mann, Matthias, Larsen, Steen, Holst, Jens J, Vilsbøll, Tina, Knop, Filip K

“…Glucagon is believed to be a pancreas-specific hormone, and hyperglucagonemia has been shown to contribute significantly to the hyperglycemic state of patients…”
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The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes by Lund, Asger, Vilsbøll, Tina, Bagger, Jonatan I, Holst, Jens J, Knop, Filip K

“…Type 2 diabetes mellitus (T2DM) is associated with reduced suppression of glucagon during oral glucose tolerance test (OGTT), whereas isoglycemic intravenous…”
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Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat by Mathiesen, David S, Lund, Asger, Vilsbøll, Tina, Knop, Filip K, Bagger, Jonatan I

“…The hormones amylin and calcitonin interact with receptors within the same family to exert their effects on the human organism. Calcitonin, derived from…”
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Increased hepatic glucagon sensitivity in totally pancreatectomised patients by Rix, Iben, Lund, Asger B, Garvey, Lars F, Hansen, Carsten P, Chabanova, Elizaveta, Hartmann, Bolette, Holst, Jens J, Vilsbøll, Tina, Van Hall, Gerrit, Knop, Filip K

“…The metabolic phenotype of totally pancreatectomised patients includes hyperaminoacidaemia and predisposition to hypoglycaemia and hepatic lipid accumulation…”
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Targeting the GLP-2 receptor in the management of obesity by Pálsson, Thorir G., Gilliam-Vigh, Hannah, Jensen, Benjamin A.H., Jeppesen, Palle B., Lund, Asger B., Knop, Filip K., Nielsen, Casper K.

“…Recent advancements in understanding glucagon-like peptide 2 (GLP-2) biology and pharmacology have sparked interest in targeting the GLP-2 receptor (GLP-2R) in…”
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Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis by Grøndahl, Magnus F G, Lange, Andreas H, Suppli, Malte P, Bagger, Jonatan I, Thing, Mira, Gluud, Lise L, Kofod, Dea H, Hornum, Mads, van Hall, Gerrit, Trammell, Samuel A J, Grevengoed, Trisha J, Hartmann, Bolette, Holst, Jens J, Vilsbøll, Tina, Christensen, Mikkel B, Lund, Asger B, Knop, Filip K

“…It is not completely clear which organs are responsible for glucagon elimination in humans, and disturbances in the elimination of glucagon could contribute to…”
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Glucagon and Type 2 Diabetes: the Return of the Alpha Cell by Lund, Asger, Bagger, Jonatan I., Christensen, Mikkel, Knop, Filip K., Vilsbøll, Tina

“…In normal physiology, glucagon from pancreatic alpha cells plays an important role in maintaining glucose homeostasis via its regulatory effect on hepatic…”
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Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals by Kliim-Hansen, Vivian, Gether, Ida M., Juel, Caroline T.-B., Ellegaard, Anne-Marie, Pedersen, Miriam G., Hartmann, Bolette, Wewer Albrechtsen, Nicolai J., Holst, Jens J., Lund, Asger B., Gasbjerg, Lærke S., Knop, Filip K.

“…Oxytocin has been proposed to possess glucose-stabilizing effects through the release of insulin and glucagon from the pancreas. Also, exogenous oxytocin has…”
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The GLP-1 receptor agonist lixisenatide reduces postprandial glucose in patients with diabetes secondary to total pancreatectomy: a randomised, placebo-controlled, double-blinded crossover trial by Juel, Caroline T. B., Lund, Asger, Andersen, Maria M., Hansen, Carsten P., Storkholm, Jan H., Rehfeld, Jens F., van Hall, Gerrit, Hartmann, Bolette, Wewer Albrechtsen, Nicolai J., Holst, Jens J., Vilsbøll, Tina, Knop, Filip K.

“…Aims/hypothesis Treatment of diabetes secondary to total pancreatectomy remains a challenge and insulin constitutes the only glucose-lowering treatment for…”
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1721-P: Effect of the TCF7L2 Variant rs7903146 T Allele on the Incretin Effect in Individuals with Normal Glucose Tolerance or Type 2 Diabetes by MATHIESEN, DAVID S., LUND, ASGER B., HANSEN, KATRINE BAGGE, JUNKER, ANDERS, IDORN, THOMAS, HORNUM, MADS, JONSSON, ANNA, HANSEN, TORBEN, VILSBØLL, TINA, BAGGER, JONATAN I., KNOP, FILIP K.

“…Background and Aim: The T allele of TCF7L2 rs7903146 is a common genetic variant associated with type 2 diabetes. The mechanisms underlying this association…”
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1952-P: Glucagon Receptor Antagonism Increases Plasma Amino Acids and Glucagon by HAEDERSDAL, SOFIE, WEWER ALBRECHTSEN, NICOLAI JACOB, LUND, ASGER B., GALSGAARD, KATRINE D., WINTHER-SOERENSEN, MARIE, HOLST, JENS J., KNOP, FILIP K., VILSBØLL, TINA

“…Hyperglucagonemia in type 2 diabetes (T2D) may result from impaired hepatic glucagon signaling and consequent reduced glucagon-induced amino acid (AA) turnover…”
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63-OR: The Physiological Effects of Extrapancreatic Glucagon in Totally Pancreatectomized Patients Evaluated Using Glucagon Receptor Antagonism by JUEL, CAROLINE T.B., LUND, ASGER B., REHFELD, JENS F., WEWER ALBRECHTSEN, NICOLAI JACOB, HOLST, JENS J., VILSBØLL, TINA, KNOP, FILIP K.

“…We have recently shown a hyperglucagonemic response to meal test and oral glucose tolerance test (OGTT) in totally pancreatectomized (PX) patients. Here, we…”
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62-OR: Evidence of Gut-Derived Glucagon in Man by BAEKDAL, MILLE, LUND, ASGER B., WEWER ALBRECHTSEN, NICOLAI JACOB, EGHOLK, JOHAN I., JORSAL, TINA, JUEL, CAROLINE T., GALSGAARD, KATRINE D., HUNT, JENNA, REHFELD, JENS F., RIGBOLT, KRISTOFFER, FRIIS, STEFFEN U., ORSKOV, CATHRINE, POULSEN, STEEN SEIER, HOLST, JENS J., VILSBØLL, TINA, KNOP, FILIP K.

“…We have previously shown that totally pancreatectomized patients (PX) and patients with type 2 diabetes (T2D) exhibit hypersecretion of glucagon in response to…”
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The effect of exogenous glucagon on circulating amino acids in individuals with and without type 2 diabetes and obesity by Grøndahl, Magnus F G, Bagger, Jonatan I, Suppli, Malte P, Van Hall, Gerrit, Albrechtsen, Nicolai J W, Holst, Jens J, Vilsbøll, Tina, Christensen, Mikkel B, Lund, Asger B, Knop, Filip K

“…In obesity and type 2 diabetes, hyperglucagonaemia may be caused by elevated levels of glucagonotropic amino acids due to hepatic glucagon resistance at the…”
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Hepatic microbiome in healthy lean and obese humans by Suppli, Malte Palm, Bagger, Jonatan Ising, Lelouvier, Benjamin, Broha, Amandine, Demant, Mia, Kønig, Merete Juhl, Strandberg, Charlotte, Lund, Asger, Vilsbøll, Tina, Knop, Filip Krag

“…Dysbiosis of the gut microbiota in response to an energy-rich Western diet and the potential leak of bacteria and/or bacterial products from the intestine to…”
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Glucose-Dependent Insulinotropic Polypeptide (GIP) Reduces Bone Resorption in Patients With Type 2 Diabetes by Christensen, Mikkel B, Lund, Asger B, Jørgensen, Niklas R, Holst, Jens J, Vilsbøll, Tina, Knop, Filip K

“…Abstract Context In healthy individuals, glucose-dependent insulinotropic polypeptide (GIP) enhances insulin secretion and reduces bone resorption by up to 25%…”
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