Search Results - "LUMSDEN, Joanne M"

Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells by Lumsden, Joanne M, Schwenk, Robert J, Rein, Lisa E, Moris, Philippe, Janssens, Michel, Ofori-Anyinam, Opokua, Cohen, Joe, Kester, Kent E, Heppner, D Gray, Krzych, Urszula

“…A phase 2a RTS,S/AS malaria vaccine trial, conducted previously at the Walter Reed Army Institute of Research, conferred sterile immunity against a primary…”
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Novel malaria antigen Plasmodium yoelii E140 induces antibody-mediated sterile protection in mice against malaria challenge by Smith, Emily C, Limbach, Keith J, Rangel, Nonenipha, Oda, Kyosuke, Bolton, Jessica S, Du, Mengyan, Gowda, Kalpana, Wang, Jianyang, Moch, J Kathleen, Sonawane, Sharvari, Velasco, Rachel, Belmonte, Arnel, Danner, Rebecca, Lumsden, Joanne M, Patterson, Noelle B, Sedegah, Martha, Hollingdale, Michael R, Richie, Thomas L, Sacci, Jr, John B, Villasante, Eileen D, Aguiar, Joao C

“…Only a small fraction of the antigens expressed by malaria parasites have been evaluated as vaccine candidates. A successful malaria subunit vaccine will…”
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Regulation of Thymic NKT Cell Development by the B7-CD28 Costimulatory Pathway by Williams, Joy A, Lumsden, Joanne M, Yu, Xiang, Feigenbaum, Lionel, Zhang, Jingjing, Steinberg, Seth M, Hodes, Richard J

“…Invariant NKT (iNKT) cells are a population of TCRalphabeta-expressing cells that are unique in several respects. In contrast to conventional T cells, iNKT…”
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Immunoglobulin class switch recombination is impaired in Atm-deficient mice by Lumsden, Joanne M, McCarty, Thomas, Petiniot, Lisa K, Shen, Rhuna, Barlow, Carrolee, Wynn, Thomas A, Morse, 3rd, Herbert C, Gearhart, Patricia J, Wynshaw-Boris, Anthony, Max, Edward E, Hodes, Richard J

“…Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by…”
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Evaluation of the Safety and Immunogenicity in Rhesus Monkeys of a Recombinant Malaria Vaccine for Plasmodium vivax with a Synthetic Toll-Like Receptor 4 Agonist Formulated in an Emulsion by LUMSDEN, Joanne M, PICHYANGKUL, Sathit, SATTABONGKOT, Jetsumon, BENNETT, Jason W, POLHEMUS, Mark E, OCKENHOUSE, Christian F, HOWARD, Randall F, YADAVA, Anjali, SRICHAIRATANAKUL, Utaiwan, YONGVANITCHIT, Kosol, LIMSALAKPETCH, Amporn, NURMUKHAMBETOVA, Saule, KLEIN, Jennifer, BERTHOLET, Sylvie, VEDVICK, Thomas S, REED, Steven G

“…OA  Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Rare Diseases Clinical Research Network: a model for clinical trial readiness by Lumsden, Joanne M., Urv, Tiina K.

“…Background: The current road to developing treatments for rare diseases is often slow, expensive, and riddled with risk. Change is needed to improve the…”
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Cross-Species Immunity Following Immunization With a Circumsporozoite Protein—Based Vaccine for Malaria by Yadava, Anjali, Nurmukhambetova, Saule, Pichugin, Alexander V., Lumsden, Joanne M.

“…Malaria continues to be a major public health concern, and there are concerted efforts to eliminate it. The quest for a vaccine remains a top priority, and…”
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Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice by Lumsden, Joanne M, Nurmukhambetova, Saule, Klein, Jennifer H, Sattabongkot, Jetsumon, Bennett, Jason W, Bertholet, Sylvie, Fox, Christopher B, Reed, Steven G, Ockenhouse, Christian F, Howard, Randall F, Polhemus, Mark E, Yadava, Anjali

“…Highlights ► This study evaluates immune responses to VMP001, a vaccine based on Plasmodium vivax CSP. ► Stable emulsion with either TLR4, TLR7/8, or in…”
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Immunization with the RTS,S/AS malaria vaccine induces IFN-γ+ CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge by Schwenk, Robert, Lumsden, Joanne M, Rein, Lisa E, Juompan, Laure, Kester, Kent E, Heppner, D. Gray, Krzych, Urszula

“…Highlights ► CD4 T cells induced by RTS,S/AS vaccine or by whole sporozoites recognize similar regions on the P falciparum CS protein. ► RTS,S/AS-induced CD4 T…”
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Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity by Hickey, Bradley W, Lumsden, Joanne M, Reyes, Sharina, Sedegah, Martha, Hollingdale, Michael R, Freilich, Daniel A, Luke, Thomas C, Charoenvit, Yupin, Goh, Lucy M, Berzins, Mara P, Bebris, Lolita, Sacci, Jr, John B, De La Vega, Patricia, Wang, Ruobing, Ganeshan, Harini, Abot, Esteban N, Carucci, Daniel J, Doolan, Denise L, Brice, Gary T, Kumar, Anita, Aguiar, Joao, Nutman, Thomas B, Leitman, Susan F, Hoffman, Stephen L, Epstein, Judith E, Richie, Thomas L

“…In this phase 1 clinical trial, healthy adult, malaria-naïve subjects were immunized with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) by…”
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The effects of B7‐dependent costimulation on T cell division and survival in vivo and in vitro are dependent on antigen concentration by Lumsden, Joanne M., Prasad, Simon J., Peach, Robert J., Ronchese, Franca

“…We used 5‐(and 6‐) carboxyfluorescein diacetate succinimidyl ester labeled TCR‐transgenic CD4+ T cells to investigate the contribution of B7 costimulation to T…”
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Highly Prolific Booroola Sheep Have a Mutation in the Intracellular Kinase Domain of Bone Morphogenetic Protein IB Receptor (ALK-6) That Is Expressed in Both Oocytes and Granulosa Cells by WILSON, Theresa, WU, Xi-Yang, MCNATTY, Kenneth P, MONTGOMERY, Grant W, JUENGEL, Jennifer L, ROSS, Ian K, LUMSDEN, Joanne M, LORD, Eric A, DODDS, Ken G, WALLING, Grant A, MCEWAN, John C, O'CONNELL, Anne R

“…The Booroola fecundity gene ( FecB ) increases ovulation rate and litter size in sheep and is inherited as a single autosomal locus. The effect of FecB is…”
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Differential Requirements for Expression of CD80/86 and CD40 on B Cells for T-Dependent Antibody Responses In Vivo by Lumsden, Joanne M, Williams, Joy A, Hodes, Richard J

“…The CD80/86-CD28 and CD40-CD40 ligand costimulatory pathways are essential for Th cell-dependent B cell responses that generate high-affinity, class-switched…”
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Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection by Lumsden, Joanne M, Roberts, Joanna M, Harris, Nicola L, Peach, Robert J, Ronchese, Franca

“…The CD28 costimulatory pathway is critical to T cell activation. Blockade of the interaction of CD28 with its ligands CD80 and CD86 using CTLA4-Ig has been…”
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Dendritic cell elimination as an assay of cytotoxic T lymphocyte activity in vivo by Ritchie, David S, Hermans, Ian F, Lumsden, Joanne M, Scanga, Connie B, Roberts, Joanna M, Yang, Jiangping, Kemp, Roslyn A, Ronchese, Franca

“…We show in this paper that the survival of antigen-loaded dendritic cells in vivo may be used as a sensitive readout of CTL activity. We have previously shown…”
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Highly Prolific Booroola Sheep Have a Mutation in the Intracellular Kinase Domain of Bone Morphogenetic Protein IB Receptor (ALK-6) That Is Expressed in Both Oocytes and Granulosa Cells1 by Wilson, Theresa, Wu, Xi-Yang, Juengel, Jennifer L, Ross, Ian K, Lumsden, Joanne M, Lord, Eric A, Dodds, Ken G, Walling, Grant A, McEwan, John C, O'Connell, Anne R, McNatty, Kenneth P, Montgomery, Grant W

“…The Booroola fecundity gene (FecB) increases ovulation rate and litter size in sheep and is inherited as a single autosomal locus. The effect of FecB is…”
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An enhanced linkage map of the sheep genome comprising more than 1000 loci by Maddox, J F, Davies, K P, Crawford, A M, Hulme, D J, Vaiman, D, Cribiu, E P, Freking, B A, Beh, K J, Cockett, N E, Kang, N, Riffkin, C D, Drinkwater, R, Moore, S S, Dodds, K G, Lumsden, J M, van Stijn, T C, Phua, S H, Adelson, D L, Burkin, H R, Broom, J E, Buitkamp, J, Cambridge, L, Cushwa, W T, Gerard, E, Galloway, S M, Harrison, B, Hawken, R J, Hiendleder, S, Henry, H M, Medrano, J F, Paterson, K A, Schibler, L, Stone, R T, van Hest, B

“…A medium-density linkage map of the ovine genome has been developed. Marker data for 550 new loci were generated and merged with the previous sheep linkage…”
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Immunization with the RTS,S/AS malaria vaccine induces IFN-[gamma]+CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge by Schwenk, Robert, Lumsden, Joanne M, Rein, Lisa E, Juompan, Laure, Kester, Kent E, Heppner, D Gray, Krzych, Urszula

“…Highlights * CD4 T cells induced by RTS,S/AS vaccine or by whole sporozoites recognize similar regions on the P falciparum CS protein. * RTS,S/AS-induced CD4 T…”
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Immunization with the RTS,S/AS malaria vaccine induces IFN-I super(3) super(+)CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge by Schwenk, Robert, Lumsden, Joanne M, Rein, Lisa E, Juompan, Laure, Kester, Kent E, Heppner, DGray, Krzych, Urszula

“…In a Phase 2a trial of the RTS,S/AS vaccine, we described significant association between protection against infection and vaccine-induced CD4 T cells. To…”
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Mapping of dentin-specific acidic phosphoprotein and integrin-binding sialoprotein in sheep defines an inversion breakpoint with respect to human chromosome 4Q by Lumsden, Joanne M., Lord, Eric A., Hirst, Karen L., Dixon, Michael J., Montgomery, Grant W.

“…Genes from sheep chromosome 6 map to human chromosome 4 in the region extending from 4p16 to 4q26. However, there is an inversion of gene order in the central…”
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