Search Results - "LUKAS, THOMAS J."

Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration by Wang, Ai Ling, Lukas, Thomas J, Yuan, Ming, Du, Nga, Tso, Mark O, Neufeld, Arthur H

“…Age-related macular degeneration (AMD) is a major cause of loss of central vision in the elderly. The formation of drusen, an extracellular, amorphous deposit…”
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The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration by Chen, Huiyi, Liu, Bin, Lukas, Thomas J, Neufeld, Arthur H

“…Although the statement that age is the greatest risk factor for Age-related macular degeneration (AMD) is widely accepted, the cellular and molecular…”
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Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes by Ju, Won-Kyu, Kim, Keun-Young, Noh, You Hyun, Hoshijima, Masahiko, Lukas, Thomas J., Ellisman, Mark H., Weinreb, Robert N., Perkins, Guy A.

“…Abnormal structure and function of astrocytes have been observed within the lamina cribrosa region of the optic nerve head (ONH) in glaucomatous…”
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Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration by Wang, Ai Ling, Lukas, Thomas J, Yuan, Ming, Du, Nga, Handa, James T, Neufeld, Arthur H

“…Age-related Macular Degeneration (AMD) is a major cause of central vision loss in the elderly and smoking is a primary risk factor associated with the…”
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ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation by Arrat, Hasan, Lukas, Thomas J, Siddique, Teepu

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology and pathology that makes the development of new therapies difficult…”
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Using LC3 to monitor autophagy flux in the retinal pigment epithelium by Wang, Ai Ling, Boulton, Michael E, Dunn, Jr, William A, Rao, Harripriya Vittal, Cai, Jun, Lukas, Thomas J, Neufeld, Arthur H

“…Autophagy is a highly conserved housekeeping pathway that plays a critical role in the removal of aged or damaged intracellular organelles and their delivery…”
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Autophagy, exosomes and drusen formation in age-related macular degeneration by Wang, Ai Ling, Lukas, Thomas J., Yuan, Ming, Du, Nga, Tso, Mark O., Neufeld, Arthur H.

“…Age-related macular degeneration (AMD) is the leading cause of loss of vision in developed countries. AMD is characterized by a progressive degeneration of the…”
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Informatics-assisted Protein Profiling in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis by Lukas, Thomas J, Luo, Wei Wei, Mao, Haihong, Cole, Natalie, Siddique, Teepu

“…One of the causes of amyotrophic lateral sclerosis (ALS) is due to mutations in Cu,Zn-superoxide dismutase (SOD1). The mutant protein exhibits a toxic gain of…”
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Gene expression and functional studies of the optic nerve head astrocyte transcriptome from normal African Americans and Caucasian Americans donors by Miao, Haixi, Chen, Lin, Riordan, Sean M, Li, Wenjun, Juarez, Santiago, Crabb, Andrea M, Lukas, Thomas J, Du, Pan, Lin, Simon M, Wise, Alexandria, Agapova, Olga A, Yang, Ping, Gu, Charles C, Hernandez, M Rosario

“…To determine whether optic nerve head (ONH) astrocytes, a key cellular component of glaucomatous neuropathy, exhibit differential gene expression in primary…”
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Early cellular signaling responses to axonal injury by Lukas, Thomas J, Wang, Ai Ling, Yuan, Ming, Neufeld, Arthur H

“…We have used optic nerve injury as a model to study early signaling events in neuronal tissue following axonal injury. Optic nerve injury results in the…”
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Dysfunction of the Retinal Pigment Epithelium with Age: Increased Iron Decreases Phagocytosis and Lysosomal Activity by Chen, Huiyi, Lukas, Thomas J, Du, Nga, Suyeoka, Genn, Neufeld, Arthur H

“…Iron accumulation with age in the retinal pigment epithelium (RPE) may be one important source of oxidative stress that contributes to age-related macular…”
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Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina by Wang, Ai Ling, Lukas, Thomas J, Yuan, Ming, Neufeld, Arthur H

“…Abstract With age, there is increased mitochondrial DNA (mtDNA) damage in the central nervous system (CNS) that may underlie, contribute or increase the…”
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Increased mitochondrial DNA damage and down-regulation of DNA repair enzymes in aged rodent retinal pigment epithelium and choroid by Wang, Ai Ling, Lukas, Thomas J, Yuan, Ming, Neufeld, Arthur H

“…In the central nervous system (CNS), increased mitochondrial DNA (mtDNA) damage is associated with aging and may underlie, contribute to, or increase the…”
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Tumor-suppressive maspin functions as a reactive oxygen species scavenger: importance of cysteine residues by Mahajan, Nitin, Shi, Heidi Y, Lukas, Thomas J, Zhang, Ming

“…Maspin is a member of the serine protease inhibitor (serpin) superfamily and displays tumor-suppressing activity by controlling cell migration, proliferation,…”
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Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression by Lukas, Thomas J., Schiltz, Gary E., Arrat, Hasan, Scheidt, Karl, Siddique, Teepu

“…The treatment of neurodegenerative diseases is difficult because of multiple etiologies and the interplay of genetics and environment as precipitating factors…”
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Pharmacodynamics of potassium channel openers in cultured neuronal networks by Wu, Calvin, V. Gopal, Kamakshi, Lukas, Thomas J., Gross, Guenter W., Moore, Ernest J.

“…A novel class of drugs – potassium (K+) channel openers or activators – has recently been shown to cause anticonvulsive and neuroprotective effects by…”
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Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain by Kudryashov, Dmitry S, Stepanova, Olga V, Vilitkevich, Elena L, Nikonenko, Tatyana A, Nadezhdina, Elena S, Shanina, Nina A, Lukas, Thomas J, Van Eldik, Linda J, Watterson, D.Martin, Shirinsky, Vladimir P

“…Recently discovered 210-kDa myosin light chain kinase (MLCK-210) is identical to 108–130 kDa MLCK, the principal regulator of the myosin II molecular motor,…”
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Modulation of factors affecting optic nerve head astrocyte migration by Miao, Haixi, Crabb, Andrea W, Hernandez, M Rosario, Lukas, Thomas J

“…The authors investigated the role of myosin light chain kinase (MYLK) and transforming growth factor beta (TGFbeta) receptor pathways in optic nerve head (ONH)…”
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Kcnq1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish by Wu, Calvin, Sharma, Kanishk, Laster, Kyle, Hersi, Mohamed, Torres, Christina, Lukas, Thomas J, Moore, Ernest J

“…KCNQx genes encode slowly activating-inactivating K+ channels, are linked to physiological signal transduction pathways, and mutations in them underlie…”
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Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors by Lukas, Thomas J, Miao, Haixi, Chen, Lin, Riordan, Sean M, Li, Wenjun, Crabb, Andrea M, Wise, Alexandria, Du, Pan, Lin, Simon M, Hernandez, M Rosario

“…Epidemiological and genetic studies indicate that ethnic/genetic background plays an important role in susceptibility to primary open angle glaucoma (POAG)…”
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