Search Results - "LUIJTEN, Mirjam"

Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens by Jacobs, Miriam N., Colacci, Annamaria, Corvi, Raffaella, Vaccari, Monica, Aguila, M. Cecilia, Corvaro, Marco, Delrue, Nathalie, Desaulniers, Daniel, Ertych, Norman, Jacobs, Abigail, Luijten, Mirjam, Madia, Federica, Nishikawa, Akiyoshi, Ogawa, Kumiko, Ohmori, Kiyomi, Paparella, Martin, Sharma, Anoop Kumar, Vasseur, Paule

“…While regulatory requirements for carcinogenicity testing of chemicals vary according to product sector and regulatory jurisdiction, the standard approach…”
Get full text

Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS) by Ehrlich, Veronika, Bil, Wieneke, Vandebriel, Rob, Granum, Berit, Luijten, Mirjam, Lindeman, Birgitte, Grandjean, Philippe, Kaiser, Andreas-Marius, Hauzenberger, Ingrid, Hartmann, Christina, Gundacker, Claudia, Uhl, Maria

“…Per- and polyfluoroalkyl substances (PFAS) are of public health concern, because of their ubiquitous and extremely persistent occurrence, and depending on…”
Get full text

New approach methodologies in human regulatory toxicology – Not if, but how and when by Schmeisser, Sebastian, Miccoli, Andrea, von Bergen, Martin, Berggren, Elisabet, Braeuning, Albert, Busch, Wibke, Desaintes, Christian, Gourmelon, Anne, Grafström, Roland, Harrill, Joshua, Hartung, Thomas, Herzler, Matthias, Kass, George E.N., Kleinstreuer, Nicole, Leist, Marcel, Luijten, Mirjam, Marx-Stoelting, Philip, Poetz, Oliver, van Ravenzwaay, Bennard, Roggeband, Rob, Rogiers, Vera, Roth, Adrian, Sanders, Pascal, Thomas, Russell S., Marie Vinggaard, Anne, Vinken, Mathieu, van de Water, Bob, Luch, Andreas, Tralau, Tewes

“…The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance,…”
Get full text

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology by Wittwehr, Clemens, Aladjov, Hristo, Ankley, Gerald, Byrne, Hugh J, de Knecht, Joop, Heinzle, Elmar, Klambauer, Günter, Landesmann, Brigitte, Luijten, Mirjam, MacKay, Cameron, Maxwell, Gavin, Meek, M E Bette, Paini, Alicia, Perkins, Edward, Sobanski, Tomasz, Villeneuve, Dan, Waters, Katrina M, Whelan, Maurice

“…Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical…”
Get full text

Internal relative potency factors based on immunotoxicity for the risk assessment of mixtures of per- and polyfluoroalkyl substances (PFAS) in human biomonitoring by Bil, Wieneke, Ehrlich, Veronika, Chen, Guangchao, Vandebriel, Rob, Zeilmaker, Marco, Luijten, Mirjam, Uhl, Maria, Marx-Stoelting, Philip, Halldorsson, Thorhallur Ingi, Bokkers, Bas

“…Created with BioRender.com [Display omitted] •RPFs were derived for immune suppressive effects using available data in rodents and humans.•RPFs were based on…”
Get full text

Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens by Oku, Yusuke, Madia, Federica, Lau, Pierre, Paparella, Martin, McGovern, Timothy, Luijten, Mirjam, Jacobs, Miriam N.

“…With recent rapid advancement of methodological tools, mechanistic understanding of biological processes leading to carcinogenesis is expanding. New approach…”
Get full text

Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts by Fraszczyk, Eliza, Spijkerman, Annemieke M. W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E. T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M. Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, Snieder, Harold

“…Aims/hypothesis Type 2 diabetes is a complex metabolic disease with increasing prevalence worldwide. Improving the prediction of incident type 2 diabetes using…”
Get full text

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations by Bajard, Lola, Adamovsky, Ondrej, Audouze, Karine, Baken, Kirsten, Barouki, Robert, Beltman, Joost B., Beronius, Anna, Bonefeld-Jørgensen, Eva Cecilie, Cano-Sancho, German, de Baat, Milo L., Di Tillio, Filippo, Fernández, Mariana F., FitzGerald, Rex E., Gundacker, Claudia, Hernández, Antonio F., Hilscherova, Klara, Karakitsios, Spyros, Kuchovska, Eliska, Long, Manhai, Luijten, Mirjam, Majid, Sanah, Marx-Stoelting, Philip, Mustieles, Vicente, Negi, Chander K., Sarigiannis, Dimosthenis, Scholz, Stefan, Sovadinova, Iva, Stierum, Rob, Tanabe, Shihori, Tollefsen, Knut Erik, van den Brand, Annick D., Vogs, Carolina, Wielsøe, Maria, Wittwehr, Clemens, Blaha, Ludek

“…While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or…”
Get full text

Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology by Harrill, Joshua A., Viant, Mark R., Yauk, Carole L., Sachana, Magdalini, Gant, Timothy W., Auerbach, Scott S., Beger, Richard D., Bouhifd, Mounir, O'Brien, Jason, Burgoon, Lyle, Caiment, Florian, Carpi, Donatella, Chen, Tao, Chorley, Brian N., Colbourne, John, Corvi, Raffaella, Debrauwer, Laurent, O'Donovan, Claire, Ebbels, Timothy M.D., Ekman, Drew R., Faulhammer, Frank, Gribaldo, Laura, Hilton, Gina M., Jones, Stephanie P., Kende, Aniko, Lawson, Thomas N., Leite, Sofia B., Leonards, Pim E.G., Luijten, Mirjam, Martin, Alberto, Moussa, Laura, Rudaz, Serge, Schmitz, Oliver, Sobanski, Tomasz, Strauss, Volker, Vaccari, Monica, Vijay, Vikrant, Weber, Ralf J.M., Williams, Antony J., Williams, Andrew, Thomas, Russell S., Whelan, Maurice

“…Omics methodologies are widely used in toxicological research to understand modes and mechanisms of toxicity. Increasingly, these methodologies are being…”
Get full text

A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences by Huber, Carolin, Nijssen, Rosalie, Mol, Hans, Philippe Antignac, Jean, Krauss, Martin, Brack, Werner, Wagner, Kevin, Debrauwer, Laurent, Maria Vitale, Chiara, James Price, Elliott, Klanova, Jana, Garlito Molina, Borja, Leon, Nuria, Pardo, Olga, Fernández, Sandra F., Szigeti, Tamás, Középesy, Szilvia, Šulc, Libor, Čupr, Pavel, Mārtiņsone, Inese, Akülova, Läsma, Ottenbros, Ilse, Vermeulen, Roel, Vlaanderen, Jelle, Luijten, Mirjam, Lommen, Arjen

“…[Display omitted] •A harmonized multi-laboratory suspect screening for pesticide metabolites was performed on 2,088 urine samples from five countries.•A…”
Get full text

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water by Moffat, Ivy, Chepelev, Nikolai L., Labib, Sarah, Bourdon-Lacombe, Julie, Kuo, Byron, Buick, Julie K., Lemieux, France, Williams, Andrew, Halappanavar, Sabina, Malik, Amal I, Luijten, Mirjam, Aubrecht, Jiri, Hyduke, Daniel R., Fornace, Albert J., Swartz, Carol D., Recio, Leslie, Yauk, Carole L.

“…Abstract Toxicogenomics is proposed to be a useful tool in human health risk assessment. However, a systematic comparison of traditional risk assessment…”
Get full text

Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals by Heusinkveld, Harm, Braakhuis, Hedwig, Gommans, Robin, Botham, Phil, Corvaro, Marco, van der Laan, Jan Willem, Lewis, Dick, Madia, Federica, Manou, Irene, Schorsch, Frédéric, Wolterink, Gerrit, Woutersen, Ruud, Corvi, Raffaella, Mehta, Jyotigna, Luijten, Mirjam

“…Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health…”
Get full text

Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts by Hölzl-Armstrong, Lisa, Kucab, Jill E., Moody, Sarah, Zwart, Edwin P., Loutkotová, Lucie, Duffy, Veronica, Luijten, Mirjam, Gamboa da Costa, Gonçalo, Stratton, Michael R., Phillips, David H., Arlt, Volker M.

“…Acrylamide is a suspected human carcinogen formed during high-temperature cooking of starch-rich foods. It is metabolised by cytochrome P450 2E1 to its…”
Get full text

A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals by Luijten, Mirjam, Corvi, Raffaella, Mehta, Jyotigna, Corvaro, Marco, Delrue, Nathalie, Felter, Susan, Haas, Bodo, Hewitt, Nicola J., Hilton, Gina, Holmes, Thomas, Jacobs, Miriam N., Jacobs, Abigail, Lamplmair, Franz, Lewis, Dick, Madia, Federica, Manou, Irene, Melching-Kollmuss, Stephanie, Schorsch, Frederic, Schütte, Katrin, Sewell, Fiona, Strupp, Christian, van der Laan, Jan Willem, Wolf, Douglas C., Wolterink, Gerrit, Woutersen, Ruud, Zvonar, Zvonimir, Heusinkveld, Harm, Braakhuis, Hedwig

“…Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies…”
Get full text

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach by Hernández, Lya G., van Steeg, Harry, Luijten, Mirjam, van Benthem, Jan

“…It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these…”
Get full text

Application of the adverse outcome pathway framework to genotoxic modes of action by Sasaki, Jennifer C., Allemang, Ashley, Bryce, Steven M., Custer, Laura, Dearfield, Kerry L., Dietz, Yasmin, Elhajouji, Azeddine, Escobar, Patricia A., Fornace, Albert J., Froetschl, Roland, Galloway, Sheila, Hemmann, Ulrike, Hendriks, Giel, Li, Heng‐Hong, Luijten, Mirjam, Ouedraogo, Gladys, Peel, Lauren, Pfuhler, Stefan, Roberts, Daniel J., Thybaud, Véronique, Benthem, Jan, Yauk, Carole L., Schuler, Maik

“…In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA)…”
Get full text

Practical Application of Next Generation Risk Assessment of Chemicals for Human Health by Luijten, Mirjam, Rorije, Emiel, Sprong, R. Corinne, van der Ven, Leo T. M

Get full text

A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals by Kirkland, David, Levy, Dan D., LeBaron, Matthew J., Aardema, Marilyn J., Beevers, Carol, Bhalli, Javed, Douglas, George R., Escobar, Patricia A., Farabaugh, Christopher S., Guerard, Melanie, Johnson, George E., Kulkarni, Rohan, Le Curieux, Frank, Long, Alexandra S., Lott, Jasmin, Lovell, David P., Luijten, Mirjam, Marchetti, Francesco, Nicolette, John J., Pfuhler, Stefan, Roberts, Daniel J., Stankowski, Leon F., Thybaud, Veronique, Weiner, Sandy K., Williams, Andrew, Witt, Kristine L., Young, Robert

“…•In vivo comet assay compared with transgenic rodent assay for 91 chemicals.•Comparison focussed on evaluation of in vivo genotoxicity per se.•Fair to good…”
Get full text

Transgenic animal models in toxicology: historical perspectives and future outlook by Boverhof, Darrell R, Chamberlain, Mark P, Elcombe, Clifford R, Gonzalez, Frank J, Heflich, Robert H, Hernández, Lya G, Jacobs, Abigail C, Jacobson-Kram, David, Luijten, Mirjam, Maggi, Adriana, Manjanatha, Mugimane G, Benthem, Jan van, Gollapudi, B Bhaskar

“…Transgenic animal models are powerful tools for developing a more detailed understanding on the roles of specific genes in biological pathways and systems…”
Get full text

Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries by Tavares, Ana Maria, Viegas, Susana, Louro, Henriqueta, Göen, Thomas, Santonen, Tiina, Luijten, Mirjam, Kortenkamp, Andreas, Silva, Maria João

“…Hexavalent chromium (Cr(VI)), nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs) are genotoxic co-occurring lung carcinogens whose occupational health…”
Get full text