Search Results - "LUETTEKE, N. C"

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase by LUETTEKE, N. C, PHILLIPS, H. K, QIU, T. H, COPELAND, N. G, EARP, H. S, JENKINS, N. A, LEE, D. C

“…Mice harboring the waved-1 (wa-1) and waved-2 (wa-2) mutations exhibit skin and eye abnormalities that are strikingly similar to those of TGF-alpha-deficient…”
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TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice by Luetteke, N C, Qiu, T H, Peiffer, R L, Oliver, P, Smithies, O, Lee, D C

“…To explore the physiological roles of transforming growth factor alpha (TGF alpha), we disrupted the mouse gene by homologous recombination in embryonic stem…”
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Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast by Sandgren, E P, Luetteke, N C, Palmiter, R D, Brinster, R L, Lee, D C

“…Metallothionein-directed expression of TGF alpha in transgenic mice induced a spectrum of changes in the growth and differentiation of certain adult tissues…”
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Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver by Sandgren, E P, Luetteke, N C, Qiu, T H, Palmiter, R D, Brinster, R L, Lee, D C

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transforming growth factor-alpha is a potential mediator of estrogen action in the mouse uterus by Nelson, K G, Takahashi, T, Lee, D C, Luetteke, N C, Bossert, N L, Ross, K, Eitzman, B E, McLachlan, J A

“…To better understand the role of peptide growth factors in sex steroid hormone-mediated growth of the female reproductive tract, the effect of estrogen on the…”
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Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development by Luetteke, N C, Qiu, T H, Fenton, S E, Troyer, K L, Riedel, R F, Chang, A, Lee, D C

“…Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the TGFalpha-knockout to generate mice lacking various combinations of the…”
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Characterization of high molecular weight transforming growth factor .alpha. produced by rat hepatocellular carcinoma cells by Luetteke, Noreen C, Michalopoulos, George K, Teixido, Joaquin, Gilmore, Reid, Massague, Joan, Lee, David C

“…In addition to the mature 50 amino acid transforming growth factor alpha (TGF alpha), some transformed cells appear to produce multiple higher molecular weight…”
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Growth Retardation, Duodenal Lesions, and Aberrant Ileum Architecture in Triple Null Mice Lacking EGF, Amphiregulin, and TGF-α by Troyer, Kelly L., Luetteke, Noreen C., Saxon, Marian L., Qiu, Ting Hu, Xian, Cory J., Lee, David C.

“…Background & Aims: Mice lacking epidermal growth factor (EGF), transforming growth factor α, and amphiregulin were used to identify roles for these EGF…”
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Partial purification and characterization of a hepatocyte growth factor produced by rat hepatocellular carcinoma cells by LUETTEKE, N. C, MICHALOPOULOS, G. K

“…Serum-free medium conditioned by confluent cultures of JM1 of JM2 rat hepatocellular carcinoma cells stimulated DNA synthesis in primary cultures of adult rat…”
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Liver regeneration and hepatocarcinogenesis in transforming growth factor-α-targeted mice by Russell, William E., Kaufmann, William K., Sitaric, Silvio, Luetteke, Noreen C., Lee, David C.

“…Transforming growth factor‐α (TGFα), a member of the epidermal growth factor receptor ligand family, has been implicated in the regeneration and transformation…”
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Regulation of fat and muscle development by transforming growth factor α in transgenic mice and in cultured cells by LUETTEKE, N. C, LEE, D. C, PALMITER, R. D, BRINSTER, R. L, SANDGREN, E. P

“…Transgenic mice overexpressing transforming growth factor alpha (TGF-alpha) under control of the metallothionein promoter had, on average, 20% reductions in…”
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Mouse Chromosomal Location of Three EGF Receptor Ligands: Amphiregulin (Areg), Betacellulin (Btc), and Heparin-Binding EGF (Hegfl) by Pathak, Bhavani G., Gilbert, Debra J., Harrison, Charles A., Luetteke, Noreen C., Chen, Xiaorong, Klagsbrun, Michael, Plowman, Gregory D., Copeland, Neal G., Jenkins, Nancy A., Lee, David C.

“…The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been…”
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Characterization of the mouse transforming growth factor α gene : Its expression during eyelid development and in waved 1 tissues by BERKOWITZ, E. A, SEROOGY, K. B, SCHROEDER, J. A, RUSSELL, W. E, EVANS, E. P, RIEDEL, R. F, PHILLIPS, H. K, HARRISON, C. A, LEE, D. C, LUETTEKE, N. C

“…The spontaneous mouse waved 1 (wa1) mutation is allelic with the transforming growth factor alpha (TGF-alpha) gene and produces phenotypes similar to those of…”
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Transforming growth factor-alpha and its role in neoplastic progression by Lee, D C, Luetteke, N C, Petch, L A

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TGF alpha is dispensable for skin tumorigenesis in Tg.AC mice by Humble, M C, Szczesniak, C J, Luetteke, N C, Spalding, J W, Cannon, R E, Hansen, L A, Lee, D C, Tennant, R W

“…Alterations in growth factor signaling pathways frequently accompany the development and maintenance of epithelial neoplasia. Transforming growth factor alpha…”
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Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells by Blasband, A J, Gilligan, D M, Winchell, L F, Wong, S T, Luetteke, N C, Rogers, K T, Lee, D C

“…TGF alpha is one member of a family of soluble growth factors that are derived from integral-membrane precursors. The mature form of TGF alpha is released from…”
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Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and -negative hepatocytes in primary culture by Gebhardt, R, Cruise, J, Houck, K A, Luetteke, N C, Novotny, A, Thaler, F, Michalopoulos, G K

“…In rat liver parenchyma, two subpopulations of hepatocytes can be distinguished by the absence or presence of the marker enzyme, glutamine synthetase (GS)…”
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Control of hepatocyte replication by two serum factors by MICHALOPOULOS, G, HOUCK, K. A, DOLAN, M. L, LUETTEKE, N. C

“…Serum proteins from hepatectomized or control rats were separated by gel permeation chromatography and assayed for stimulation of hepatocyte proliferation in…”
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Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusion by Carroll, Joseph M., Luetteke, Noreen C., Lee, David C., Watt, Fiona M.

“…Eyelid fusion normally occurs between E15.5 and E16.5 of mouse embryonic development and results from the migration of a population of periderm-derived…”
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Transforming growth factor alpha: expression, regulation and biological action of its integral membrane precursor by Luetteke, N C, Lee, D C

“…Transforming growth factor alpha (TGF alpha) is a 6 kDa polypeptide mitogen that interacts with the epidermal growth factor receptor and activates its…”
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